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WIREs Syst Biol Med
Impact Factor: 2.385
Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 10 Issue 1 (January/February 2018)
Page 0 - 0

Cover Image

Cover Image, Volume 10, Issue 1
Published Online: Dec 15 2017
DOI: 10.1002/wsbm.1414
The cover image, by Gianmarco Rinaldi et al., is based on Advanced Review Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape, DOI: 10.1002/wsbm.1397.
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Opinion

Targeting epidermal growth factor receptor co‐dependent signaling pathways in glioblastoma
Published Online: Sep 11 2017
DOI: 10.1002/wsbm.1398
The epidermal growth factor receptor (EGFR) is a transmembrane protein that transduces intracellular signaling pathways upon the binding with its ligand EGF. In Glioblastoma (GBM), amplified and mutated EGFR (sometimes appearing in extrachromosomal DNA, ecDNA) leads to constitutively active EGFR signaling even in the absence of EGF binding. The resulting hyper‐activated EGFR reprograms the epigenome and metabolic pathways to drive uncontrollable cell proliferation and tumor growth. Targeting these EGFR co‐dependent pathways in GBM may offer new revenues to develop anti‐cancer therapy.
Abstract Full article on Wiley Online Library:   HTML | PDF

Primer

Stability analysis in spatial modeling of cell signaling
Published Online: Aug 08 2017
DOI: 10.1002/wsbm.1395
Spatial patterns are common in biological systems at multiple scales ranging from shells and animal skin to intracellular signaling. In this primer, we provide an introduction for stability analysis for cell signaling.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Review

Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape
Published Online: Aug 30 2017
DOI: 10.1002/wsbm.1397
Understanding complex metabolic interactions in cancer is important for the design of novel therapeutic strategies.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Immunity to CRISPR Cas9 and Cas12a therapeutics
Published Online: Oct 30 2017
DOI: 10.1002/wsbm.1408
Adverse outcomes from immune responses: key challenge is to make CRISPR‐Cas9 and Cas12a (Cpf1) genome‐editing therapeutics less immunogenic.
Abstract Full article on Wiley Online Library:   HTML | PDF
Crosstalk between transcription and metabolism: how much enzyme is enough for a cell?
Published Online: Aug 15 2017
DOI: 10.1002/wsbm.1396
Crosstalk between metabolism and transcription tunes enzyme levels. While low enzyme levels are cost efficient, high enzyme levels provide robust metabolic operation.
Abstract Full article on Wiley Online Library:   HTML | PDF
Dynamic enhancer function in the chromatin context
Published Online: May 22 2017
DOI: 10.1002/wsbm.1390
In live cells, many enhancer‐binding transcription factors exchange rapidly with their binding sites in enhancers and leave no footprints in chromatin. Available data suggest a highly dynamic mechanism for enhancer activation, involving numerous stochastic binding events at a target enhancer.
Abstract Full article on Wiley Online Library:   HTML | PDF

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In the Spotlight

Jens Nielsen

Jens Nielsen
is a Professor in the Department of Biology and Biological Engineering at Chalmers University of Technology in Göteborg, Sweden. His research focus is on systems biology of metabolism. The yeast Saccharomyces cerevisiae is the lab’s key organism for experimental research, but they also work with Aspergilli oryzae.

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