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WIREs Syst Biol Med
Impact Factor: 3.709
Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 10 Issue 2 (March/April 2018)
Page 0 - 0

Cover Image

Cover Image, Volume 10, Issue 2
Published Online: Feb 15 2018
DOI: 10.1002/wsbm.1420
The cover image, by Chris Fields and Michael Levin, is based on Overview Multiscale memory and bioelectric error correction in the cytoplasm–cytoskeleton‐membrane system, DOI: 10.1002/wsbm.1410.
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

Multiscale memory and bioelectric error correction in the cytoplasm–cytoskeleton‐membrane system
Published Online: Nov 17 2017
DOI: 10.1002/wsbm.1410
The information determining large‐scale anatomical features of an organism is encoded in a variety of physical processes and not entirely in the genome. Dissociations between genome‐default anatomical states and actual growth and form can be observed in model systems such as planaria as pattern memories, including those stored in bioelectric networks among somatic cell groups, can be re‐written to result in stable production of animals with different target morphologies after each regeneration event. Planaria, which reproduce by fission, starkly reveal the gap between genome and anatomy, as they maintain perfect anatomical fidelity even as they accumulate mutations over millions of years of somatic inheritance.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Computational modeling of single‐cell mechanics and cytoskeletal mechanobiology
Published Online: Nov 30 2017
DOI: 10.1002/wsbm.1407
A computational model of a cell embedded within a 3D collagen extracellular matrix depicting actin polymerization (green) at the front, and actomyosin filament contractions at the back (red). In this review we discuss mathematical modeling approaches to study cell and cytoskeletal mechanics and the experiments that have informed these models to date.
Abstract Full article on Wiley Online Library:   HTML | PDF
Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond
Published Online: Oct 09 2017
DOI: 10.1002/wsbm.1406
Metabolism promotes metastatic progression and supports metastatic cancer cells through diverse, interlinked, and overlapping mechanisms.
Abstract Full article on Wiley Online Library:   HTML | PDF
Small molecule signaling, regulation, and potential applications in cellular therapeutics
Published Online: Sep 28 2017
DOI: 10.1002/wsbm.1405
Small molecule signaling and regulation can be harnessed for the control of bacterial cellular therapeutics.
Abstract Full article on Wiley Online Library:   HTML | PDF

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