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WIREs Syst Biol Med
Impact Factor: 2.941
Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 2 Issue 2 (March/April 2010)
Page 127 - 251

Editorial Commentary

Systems Biology and Medicine—Meta‐Issues and Frameworks
Published Online: Mar 26 2010
DOI: 10.1002/wsbm.98
Abstract Full article on Wiley Online Library:   HTML | PDF

Opinion

The network as the target
Published Online: Sep 29 2009
DOI: 10.1002/wsbm.57
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

Toward a VPH/Physiome ToolKit
Published Online: Sep 29 2009
DOI: 10.1002/wsbm.63
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Systems approaches and algorithms for discovery of combinatorial therapies
Published Online: Sep 01 2009
DOI: 10.1002/wsbm.51
Abstract Full article on Wiley Online Library:   HTML | PDF
Computational modeling of mammalian signaling networks
Published Online: Aug 14 2009
DOI: 10.1002/wsbm.52
Abstract Full article on Wiley Online Library:   HTML | PDF
MicroRNA targeting in mammalian genomes: genes and mechanisms
Published Online: Aug 14 2009
DOI: 10.1002/wsbm.53
Abstract Full article on Wiley Online Library:   HTML | PDF
Systematic analysis of posttranscriptional gene expression
Published Online: Aug 14 2009
DOI: 10.1002/wsbm.54
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Circuitry of mRNA regulation
Published Online: Sep 30 2009
DOI: 10.1002/wsbm.55
Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐wide DNA methylation profiling
Published Online: Sep 29 2009
DOI: 10.1002/wsbm.35
Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling the architecture and dynamics of hematopoiesis
Published Online: Sep 18 2009
DOI: 10.1002/wsbm.56
Abstract Full article on Wiley Online Library:   HTML | PDF
Multiplex parallel pair‐end‐ditag sequencing approaches in system biology
Published Online: Aug 14 2009
DOI: 10.1002/wsbm.40
Abstract Full article on Wiley Online Library:   HTML | PDF

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In the Spotlight

Philip Benfey

Philip Benfey

Is intrigued by one of the key questions in developmental biology: how cells acquire their identities. This is an important question in human development, where stem cells divide and differentiate into skin, muscle, fat etc. It is equally central to plant development, where most organs and cells are formed from stem cell populations known as meristems. The Benfey lab addresses this question using a combination of genetics, molecular biology, and genomics to identify and characterize the genes that regulate formation of the root in the plant model system, Arabidopsis thaliana. The choice of the root as a model was based on the simplicity of its organization and its stereotyped developmental program.

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