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WIREs Syst Biol Med
Impact Factor: 3.676
Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 3 Issue 1 (January/February 2011)
Page 1 - 125

Opinion

An energy systems approach to Parkinson's disease
Published Online: Jul 16 2010
DOI: 10.1002/wsbm.107
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

An interdisciplinary systems approach to study sperm physiology and evolution
Published Online: Jul 26 2010
DOI: 10.1002/wsbm.106
Abstract Full article on Wiley Online Library:   HTML | PDF
Synthetic biology: putting synthesis into biology
Published Online: Jul 13 2010
DOI: 10.1002/wsbm.104
Abstract Full article on Wiley Online Library:   HTML | PDF
Advances in analysis of transcriptional regulatory networks
Published Online: Jul 08 2010
DOI: 10.1002/wsbm.105
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Hybrid models of tumor growth
Published Online: Jul 07 2010
DOI: 10.1002/wsbm.102
Abstract Full article on Wiley Online Library:   HTML | PDF
Maintenance and differentiation of neural stem cells
Published Online: Jun 21 2010
DOI: 10.1002/wsbm.100
Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium dynamics and signaling in vascular regulation: computational models
Published Online: Jun 21 2010
DOI: 10.1002/wsbm.97
Abstract Full article on Wiley Online Library:   HTML | PDF
Electrophysiological models of neural processing
Published Online: Apr 22 2010
DOI: 10.1002/wsbm.95
Abstract Full article on Wiley Online Library:   HTML | PDF
The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication
Published Online: Apr 15 2010
DOI: 10.1002/wsbm.88
Abstract Full article on Wiley Online Library:   HTML | PDF

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In the Spotlight

William J. Pavan

William J. Pavan

is interested in using genomic tools to understand how an embryo develops into a functioning organism. His group focuses on neural crest cells, a group of stem cells that differentiate into a wide variety of tissues in the bodys. Issues with the development of the neural crest cells can cause many diseases, ranging from Waardenburg syndrome to cleft lip and palate. Using genomic research tools, Dr. Pavan seeks to identify the genes necessary for normal neural crest cell development, specifically the ones which differentiate into melanocytes. At least 15 genes have been recognized as important in the development of neural crest cells, but there are likely hundreds of genes involved in total. Dr. Pavan’s lab often uses the models of neural crest cell disorders in mice in order to identify the genes needed for normal development. They then study how these genes function, and whether there are corresponding genes in humans that can cause human diseases.

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