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WIREs Syst Biol Med
Impact Factor: 3.676
Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 4 Issue 1 (January/February 2012)
Page 1 - 127

Opinion

Integrative physical oncology
Published Online: Aug 18 2011
DOI: 10.1002/wsbm.158
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

A systems biology approach to synovial joint lubrication in health, injury, and disease
Published Online: Aug 08 2011
DOI: 10.1002/wsbm.157
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Regulatory gene network circuits underlying T cell development from multipotent progenitors
Published Online: Oct 04 2011
DOI: 10.1002/wsbm.162
Abstract Full article on Wiley Online Library:   HTML | PDF
Normal morphogenesis of epithelial tissues and progression of epithelial tumors
Published Online: Sep 02 2011
DOI: 10.1002/wsbm.159
Abstract Full article on Wiley Online Library:   HTML | PDF
Stem cell genome‐to‐systems biology
Published Online: Apr 11 2011
DOI: 10.1002/wsbm.151
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Modeling of spatially‐restricted intracellular signaling
Published Online: Jul 15 2011
DOI: 10.1002/wsbm.155
Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanistic modeling to investigate signaling by oncogenic Ras mutants
Published Online: Jul 15 2011
DOI: 10.1002/wsbm.156
Abstract Full article on Wiley Online Library:   HTML | PDF

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In the Spotlight

William J. Pavan

William J. Pavan

is interested in using genomic tools to understand how an embryo develops into a functioning organism. His group focuses on neural crest cells, a group of stem cells that differentiate into a wide variety of tissues in the bodys. Issues with the development of the neural crest cells can cause many diseases, ranging from Waardenburg syndrome to cleft lip and palate. Using genomic research tools, Dr. Pavan seeks to identify the genes necessary for normal neural crest cell development, specifically the ones which differentiate into melanocytes. At least 15 genes have been recognized as important in the development of neural crest cells, but there are likely hundreds of genes involved in total. Dr. Pavan’s lab often uses the models of neural crest cell disorders in mice in order to identify the genes needed for normal development. They then study how these genes function, and whether there are corresponding genes in humans that can cause human diseases.

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