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WIREs Syst Biol Med
Impact Factor: 4.275

Biological Mechanisms

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Toward a systems‐level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile

Focus Article
Pamela V. Tran, Salil A. Lachke, Rolf W. Stottmann
Published Online: Oct 11 2012
DOI:10.1002/wsbm.1193

Abstract Full article on Wiley Online Library:   HTML | PDF
Role of fibroblast growth factor signaling in vascular formation and maintenance: orchestrating signaling networks as an integrated system

Focus Article
Takashi Sakurai, Masahiro Murakami
Published Online: Aug 28 2012
DOI:10.1002/wsbm.1190

Abstract Full article on Wiley Online Library:   HTML | PDF
Post‐translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding

Advanced Review
Sudhakaran Prabakaran, Guy Lippens, Hanno Steen, Jeremy Gunawardena
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1185

Abstract Full article on Wiley Online Library:   HTML | PDF
From base pair to bedside: molecular simulation and the translation of genomics to personalized medicine

Advanced Review
David W. Wright, Shunzhou Wan, Nour Shublaq, Stefan J. Zasada, Peter V. Coveney
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1186

Abstract Full article on Wiley Online Library:   HTML | PDF
The role of regulatory T cells in neurodegenerative diseases

Advanced Review
Feng He, Rudi Balling
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1187

Abstract Full article on Wiley Online Library:   HTML | PDF
The molecular circuitry underlying pluripotency in embryonic stem cells

Advanced Review
Aryeh Warmflash, Brigitte L. Arduini, Ali H. Brivanlou
Published Online: Jul 03 2012
DOI:10.1002/wsbm.1182

Abstract Full article on Wiley Online Library:   HTML | PDF
Decoding the functions of post‐transcriptional regulators in the determination of inflammatory states: focus on macrophage activation

Focus Article
Panagiota Kafasla, Ioannis Karakasiliotis, Dimitris L. Kontoyiannis
Published Online: Jul 03 2012
DOI:10.1002/wsbm.1179

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology approaches to toll‐like receptor signaling

Focus Article
Alexis Vandenbon, Shunsuke Teraguchi, Shizuo Akira, Kiyoshi Takeda, Daron M. Standley
Published Online: Jun 19 2012
DOI:10.1002/wsbm.1178

Abstract Full article on Wiley Online Library:   HTML | PDF
Hydrogels for in vivo‐like three‐dimensional cellular studies

Advanced Review
Hyun‐Joon Kong, Ross DeVolder
Published Online: May 21 2012
DOI:10.1002/wsbm.1174

Abstract Full article on Wiley Online Library:   HTML | PDF
Sex and the circuitry: progress toward a systems‐level understanding of vertebrate sex determination

Focus Article
Steven C. Munger, Blanche Capel
Published Online: May 17 2012
DOI:10.1002/wsbm.1172

Abstract Full article on Wiley Online Library:   HTML | PDF
Understanding multimodal biological decisions from single cell and population dynamics

Advanced Review
Kumar Selvarajoo
Published Online: May 14 2012
DOI:10.1002/wsbm.1175

Abstract Full article on Wiley Online Library:   HTML | PDF
Theoretical insights into bacterial chemotaxis

Advanced Review
Marcus J. Tindall, Eamonn A. Gaffney, Philip K. Maini, Judith P. Armitage
Published Online: Mar 12 2012
DOI:10.1002/wsbm.1168

Abstract Full article on Wiley Online Library:   HTML | PDF
Linking genome to epigenome

Focus Article
Guo‐Cheng Yuan
Published Online: Feb 17 2012
DOI:10.1002/wsbm.1165

Abstract Full article on Wiley Online Library:   HTML | PDF
Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development

Focus Article
Judith Schütte, Victoria Moignard, Berthold Göttgens
Published Online: Feb 14 2012
DOI:10.1002/wsbm.1163

Abstract Full article on Wiley Online Library:   HTML | PDF
Reverse‐engineering human regulatory networks

Advanced Review
Celine Lefebvre, Gabrielle Rieckhof, Andrea Califano
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1159

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale models of thrombogenesis

Advanced Review
Zhiliang Xu, Oleg Kim, Malgorzata Kamocka, Elliot D. Rosen, Mark Alber
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1160

Abstract Full article on Wiley Online Library:   HTML | PDF
Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers

Focus Article
Eric M. Balzer, Konstantinos Konstantopoulos
Published Online: Sep 12 2011
DOI:10.1002/wsbm.160

Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanistic modeling to investigate signaling by oncogenic Ras mutants

Focus Article
Edward C. Stites, Kodi S. Ravichandran
Published Online: Jul 15 2011
DOI:10.1002/wsbm.156

Abstract Full article on Wiley Online Library:   HTML | PDF
Noncoding RNAs in gene regulation

Focus Article
Maxime Wery, Marta Kwapisz, Antonin Morillon
Published Online: Mar 04 2011
DOI:10.1002/wsbm.148

Abstract Full article on Wiley Online Library:   HTML | PDF
Lipid‐sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome

Advanced Review
Michele Vacca, Chiara Degirolamo, Renato Mariani‐Costantini, Giuseppe Palasciano, Antonio Moschetta
Published Online: Feb 16 2011
DOI:10.1002/wsbm.137

Abstract Full article on Wiley Online Library:   HTML | PDF
Role of the nuclear envelope in genome organization and gene expression

Advanced Review
David W. Van de Vosse, Yakun Wan, Richard W. Wozniak, John D. Aitchison
Published Online: Feb 08 2011
DOI:10.1002/wsbm.101

Abstract Full article on Wiley Online Library:   HTML | PDF
Signaling pathways that control cell migration: models and analysis

Focus Article
Erik S. Welf, Jason M. Haugh
Published Online: Feb 08 2011
DOI:10.1002/wsbm.110

Abstract Full article on Wiley Online Library:   HTML | PDF
Adaptation of cells to new environments

Advanced Review
Aaron N. Brooks, Serdar Turkarslan, Karlyn D. Beer, Fang Yin Lo, Nitin S. Baliga
Published Online: Dec 31 2010
DOI:10.1002/wsbm.136

Abstract Full article on Wiley Online Library:   HTML | PDF
Network biology: a direct approach to study biological function

Overview
Frank Emmert‐Streib, Galina V. Glazko
Published Online: Dec 31 2010
DOI:10.1002/wsbm.134

Abstract Full article on Wiley Online Library:   HTML | PDF
Advances in analysis of transcriptional regulatory networks

Advanced Review
Peter J. Park, Tae‐Min Kim
Published Online: Dec 16 2010
DOI:10.1002/wsbm.105

Abstract Full article on Wiley Online Library:   HTML | PDF
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