Eukaryotic chemotaxis
Focus Article
Wouter‐Jan Rappel, William F. Loomis
Published Online: May 05 2009
DOI:10.1002/wsbm.28
How to cite this WIREs title:
WIREs Syst Biol Med
WIREs Syst Biol Med
Impact Factor: 4.192
Models of Systems Properties and Processes
Regulating cellular cyclic adenosine monophosphate: “Sources,” “sinks,” and now, “tunable valves”
Focus Article
Pradipta Ghosh, Padmini Rangamani, Michael Getz
Published Online: Apr 23 2020
DOI:10.1002/wsbm.1490
Molecular networks in Network Medicine: Development and applications
Advanced Review
Edwin K. Silverman, Harald H. H. W. Schmidt, Eleni Anastasiadou, Lucia Altucci, Marco Angelini, Lina Badimon, Jean‐Luc Balligand, Giuditta Benincasa, Giovambattista Capasso, Federica Conte, Antonella Di Costanzo, Lorenzo Farina, Giulia Fiscon, Laurent Gatto, Michele Gentili, Joseph Loscalzo, Cinzia Marchese, Claudio Napoli, Paola Paci, Manuela Petti, John Quackenbush, Paolo Tieri, Davide Viggiano, Gemma Vilahur, Kimberly Glass, Jan Baumbach
Published Online: Apr 19 2020
DOI:10.1002/wsbm.1489
Multiscale modeling of vertebrate limb development
Advanced Review
Tilmann Glimm, Ramray Bhat, Stuart A. Newman
Published Online: Mar 24 2020
DOI:10.1002/wsbm.1485
Aspirin and the chemoprevention of cancers: A mathematical and evolutionary dynamics perspective
Advanced Review
Natalia L. Komarova, C. Richard Boland, Ajay Goel, Dominik Wodarz
Published Online: Mar 12 2020
DOI:10.1002/wsbm.1487
Modeling immune cell behavior across scales in cancer
Advanced Review
Sahak Z. Makaryan, Colin G. Cess, Stacey D. Finley
Published Online: Mar 04 2020
DOI:10.1002/wsbm.1484
Calibration of ionic and cellular cardiac electrophysiology models
Advanced Review
Dominic G. Whittaker, Michael Clerx, Chon Lok Lei, David J. Christini, Gary R. Mirams
Published Online: Feb 21 2020
DOI:10.1002/wsbm.1482
Intracellular signaling dynamics and their role in coordinating tissue repair
Focus Article
Samuel J. Ghilardi, Breanna M. O'Reilly, Allyson E. Sgro
Published Online: Feb 08 2020
DOI:10.1002/wsbm.1479
Cholesterol interaction motifs in G protein‐coupled receptors: Slippery hot spots?
Advanced Review
Parijat Sarkar, Amitabha Chattopadhyay
Published Online: Feb 07 2020
DOI:10.1002/wsbm.1481
How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post‐infarction patients
Advanced Review
Natalia A. Trayanova, Ashish N. Doshi, Adityo Prakosa
Published Online: Jan 09 2020
DOI:10.1002/wsbm.1477
Growth control in the Drosophila wing disk
Advanced Review
Jia Gou, Jay A. Stotsky, Hans G. Othmer
Published Online: Jan 09 2020
DOI:10.1002/wsbm.1478
Theory of cell fate
Primer
Michael J. Casey, Patrick S. Stumpf, Ben D. MacArthur
Published Online: Dec 12 2019
DOI:10.1002/wsbm.1471
Exploring cardiac form and function: A length‐scale computational biology approach
Advanced Review
William F. Sherman, Anna Grosberg
Published Online: Dec 02 2019
DOI:10.1002/wsbm.1470
Network architecture and regulatory logic in neural crest development
Focus Article
Marcos Simoes‐Costa, Megan Rothstein, Austin S. Hovland
Published Online: Nov 08 2019
DOI:10.1002/wsbm.1468
Skeletal muscle: A review of molecular structure and function, in health and disease
Advanced Review
Kavitha Mukund, Shankar Subramaniam
Published Online: Aug 13 2019
DOI:10.1002/wsbm.1462
Hybrid modeling frameworks of tumor development and treatment
UPDATE
Ibrahim M. Chamseddine, Katarzyna A. Rejniak
Published Online: Jul 17 2019
DOI:10.1002/wsbm.1461
Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methods
Advanced Review
Luca Marchetti, Corrado Priami, Federico Reali, Giulia Simoni
Published Online: Jul 01 2019
DOI:10.1002/wsbm.1459
Agent‐based models of inflammation in translational systems biology: A decade later
UPDATE
Gary An, Yoram Vodovotz
Published Online: Jul 01 2019
DOI:10.1002/wsbm.1460
Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics
Advanced Review
Thomas Heidlauf, Francesco Negro, Thomas Klotz, Utku Ş. Yavuz, Oliver Röhrle
Published Online: Jun 24 2019
DOI:10.1002/wsbm.1457
IL7 receptor signaling in T cells: A mathematical modeling perspective
Overview
Jung‐Hyun Park, Adam T. Waickman, Joseph Reynolds, Mario Castro, Carmen Molina‐París
Published Online: May 28 2019
DOI:10.1002/wsbm.1447
Essential contributions of enhancer genomic regulatory elements to microglial cell identity and functions
Focus Article
André Machado Xavier, Sarah Belhocine, David Gosselin
Published Online: Apr 23 2019
DOI:10.1002/wsbm.1449
Calcium signals that determine vascular resistance
Focus Article
Matteo Ottolini, Kwangseok Hong, Swapnil K. Sonkusare
Published Online: Mar 18 2019
DOI:10.1002/wsbm.1448
Towards multiscale modeling of the CD8+ T cell response to viral infections
Advanced Review
Subhasish Baral, Rubesh Raja, Pramita Sen, Narendra M. Dixit
Published Online: Feb 27 2019
DOI:10.1002/wsbm.1446
Integrating molecular networks with genetic variant interpretation for precision medicine
Overview
Emidio Capriotti, Kivilcim Ozturk, Hannah Carter
Published Online: Dec 12 2018
DOI:10.1002/wsbm.1443
Systems biology of robustness and homeostatic mechanisms
Overview
H. Frederik Nijhout, Janet A. Best, Michael C. Reed
Published Online: Oct 29 2018
DOI:10.1002/wsbm.1440
Mathematical modeling of circadian rhythms
Focus Article
Ameneh Asgari‐Targhi, Elizabeth B. Klerman
Published Online: Oct 17 2018
DOI:10.1002/wsbm.1439
Context‐dependent regulation of receptor tyrosine kinases: Insights from systems biology approaches
Focus Article
Inez Lam, Christina M. Pickering, Feilim Mac Gabhann
Published Online: Sep 26 2018
DOI:10.1002/wsbm.1437
The mammalian mycobiome: A complex system in a dynamic relationship with the host
Advanced Review
Ghee Chuan Lai, Tze Guan Tan, Norman Pavelka
Published Online: Sep 25 2018
DOI:10.1002/wsbm.1438
Computational methods for analyzing and modeling genome structure and organization
Focus Article
Dejun Lin, Giancarlo Bonora, Galip Gürkan Yardımcı, William S. Noble
Published Online: Jul 18 2018
DOI:10.1002/wsbm.1435
Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+‐Ca2+‐Ca2+/calmodulin‐dependent protein kinase II‐reactive oxygen species feedback
Focus Article
Stefano Morotti, Eleonora Grandi
Published Online: Jul 17 2018
DOI:10.1002/wsbm.1434
Computational anatomy and diffeomorphometry: A dynamical systems model of neuroanatomy in the soft condensed matter continuum
Advanced Review
Laurent Younes, Daniel J. Tward, Sylvain Arguillère, Michael I. Miller
Published Online: Jun 04 2018
DOI:10.1002/wsbm.1425
Kinetic models of hematopoietic differentiation
Advanced Review
Carsten Peterson, Victor Olariu
Published Online: Apr 16 2018
DOI:10.1002/wsbm.1424
Multiscale systems biology of trauma‐induced coagulopathy
Focus Article
Scott L. Diamond, Talid Sinno, Carrie Sims, Evan Tsiklidis
Published Online: Feb 27 2018
DOI:10.1002/wsbm.1418
Genome‐scale metabolic models applied to human health and disease
Advanced Review
Jens Nielsen, Daniel J Cook
Published Online: Jun 23 2017
DOI:10.1002/wsbm.1393
Image‐based computational fluid dynamics in the lung: virtual reality or new clinical practice?
Advanced Review
Haribalan Kumar, Jan De Backer, Kelly S. Burrowes
Published Online: Jun 13 2017
DOI:10.1002/wsbm.1392
The best models of metabolism
Advanced Review
Eberhard O. Voit
Published Online: May 19 2017
DOI:10.1002/wsbm.1391
Biomechanics of the human uterus
Focus Article
Kristin M. Myers, David Elad
Published Online: May 12 2017
DOI:10.1002/wsbm.1388
Systems biology of cellular membranes: a convergence with biophysics
Advanced Review
Morgan Chabanon, Jeanne C. Stachowiak, Padmini Rangamani
Published Online: May 05 2017
DOI:10.1002/wsbm.1386
Trends in high‐throughput and functional neuroimaging in Caenorhabditis elegans
Focus Article
Yongmin Cho, Charles L. Zhao, Hang Lu
Published Online: Feb 21 2017
DOI:10.1002/wsbm.1376
Recent lab‐on‐chip developments for novel drug discovery
Opinion
Nauman Khalid, Isao Kobayashi, Mitsutoshi Nakajima
Published Online: Feb 17 2017
DOI:10.1002/wsbm.1381
Understanding the mTOR signaling pathway via mathematical modeling
Advanced Review
Melanie Boerries, Hauke Busch, Martin Klose, Nurgazy Sulaimanov
Published Online: Feb 10 2017
DOI:10.1002/wsbm.1379
Multiscale modeling methods in biomechanics
Advanced Review
Pinaki Bhattacharya, Marco Viceconti
Published Online: Jan 19 2017
DOI:10.1002/wsbm.1375
Insights into nuclear dynamics using live‐cell imaging approaches
Advanced Review
Rachel B. Bigley, Alexander Y. Payumo, Jeffrey M. Alexander, Guo N. Huang
Published Online: Jan 12 2017
DOI:10.1002/wsbm.1372
Toward modeling locomotion using electromyography‐informed 3D models: application to cerebral palsy
Focus Article
M. Sartori, J. W. Fernandez, L. Modenese, C. P. Carty, L. A. Barber, K. Oberhofer, J. Zhang, G. G. Handsfield, N. S. Stott, T. F. Besier, D. Farina, D. G. Lloyd
Published Online: Dec 21 2016
DOI:10.1002/wsbm.1368
Modeling, signaling and cytoskeleton dynamics: integrated modeling‐experimental frameworks in cell migration
Advanced Review
Meng Sun, Muhammad H. Zaman
Published Online: Nov 15 2016
DOI:10.1002/wsbm.1365
Mathematical modeling of the female reproductive system: from oocyte to delivery
Overview
Alys R Clark, Jennifer A Kruger
Published Online: Sep 09 2016
DOI:10.1002/wsbm.1353
In silico bone mechanobiology: modeling a multifaceted biological system
Advanced Review
Mario Giorgi, Stefaan W. Verbruggen, Damien Lacroix
Published Online: Sep 07 2016
DOI:10.1002/wsbm.1356
Modeling the second stage of labor
Focus Article
Xiani Yan, Jennifer A. Kruger, Xinshan Li, Poul M. F. Nielsen, Martyn P. Nash
Published Online: Aug 25 2016
DOI:10.1002/wsbm.1351
Systems‐level airway models of bronchoconstriction
Focus Article
Graham M. Donovan
Published Online: Jun 27 2016
DOI:10.1002/wsbm.1349
Omics‐based approaches to understand mechanosensitive endothelial biology and atherosclerosis
Advanced Review
Rachel D. Simmons, Sandeep Kumar, Salim Raid Thabet, Sanjoli Sur, Hanjoong Jo
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1344
Systems physiology of the airways in health and obstructive pulmonary disease
Advanced Review
Jason H.T. Bates
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1347
Multiscale modeling of brain dynamics: from single neurons and networks to mathematical tools
Advanced Review
Constantinos Siettos, Jens Starke
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1348
Mathematical models of breast and ovarian cancers
Advanced Review
Dana‐Adriana Botesteanu, Stanley Lipkowitz, Jung‐Min Lee, Doron Levy
Published Online: Jun 03 2016
DOI:10.1002/wsbm.1343
Role of frameshift ubiquitin B protein in Alzheimer's disease
Advanced Review
Xin Chen, Dina Petranovic
Published Online: May 30 2016
DOI:10.1002/wsbm.1340
Signaling via the NFκB system
Advanced Review
Simon Mitchell, Jesse Vargas, Alexander Hoffmann
Published Online: Mar 16 2016
DOI:10.1002/wsbm.1331
Heart valve regeneration: the need for systems approaches
Focus Article
Jenna Usprech, Wen Li Kelly Chen, Craig A. Simmons
Published Online: Feb 09 2016
DOI:10.1002/wsbm.1329
Aging and computational systems biology
Advanced Review
Mark T. Mc Auley, Amy E. Morgan, Kathleen M. Mooney
Published Online: Jan 29 2016
DOI:10.1002/wsbm.1328
Modeling microcirculatory blood flow: current state and future perspectives
Focus Article
Dmitry A. Fedosov, Gerhard Gompper
Published Online: Dec 22 2015
DOI:10.1002/wsbm.1326
Dynamics of the mammalian cell cycle in physiological and pathological conditions
Focus Article
Claude Gérard, Albert Goldbeter
Published Online: Nov 27 2015
DOI:10.1002/wsbm.1325
Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte
Advanced Review
Raimond L. Winslow, Mark A. Walker, Joseph L. Greenstein
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1322
The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications
Advanced Review
Peng Du, Niranchan Paskaranandavadivel, Timothy R. Angeli, Leo K. Cheng, Gregory O'Grady
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1324
In search for symmetries in the metabolism of cancer
Advanced Review
Francesco Gatto, Jens Nielsen
Published Online: Nov 05 2015
DOI:10.1002/wsbm.1321
The macrophage and its role in inflammation and tissue repair: mathematical and systems biology approaches
Focus Article
Joanne L. Dunster
Published Online: Oct 13 2015
DOI:10.1002/wsbm.1320
Systems analysis of host–parasite interactions
Advanced Review
Justine Swann, Neema Jamshidi, Nathan E. Lewis, Elizabeth A. Winzeler
Published Online: Aug 26 2015
DOI:10.1002/wsbm.1311
Measurement and modeling of coronary blood flow
Overview
Matthew D. Sinclair, Jack Lee, Andrew N. Cookson, Simone Rivolo, Eoin R. Hyde, Nicolas P. Smith
Published Online: Jun 30 2015
DOI:10.1002/wsbm.1309
Topology, dynamics, and heterogeneity in immune signaling
Advanced Review
J. Taylor Webb, Marcelo Behar
Published Online: May 27 2015
DOI:10.1002/wsbm.1306
The cell as the mechanistic basis for evolution
Advanced Review
J.S. Torday
Published Online: May 25 2015
DOI:10.1002/wsbm.1305
Systems biology of host–microbe metabolomics
Advanced Review
Almut Heinken, Ines Thiele
Published Online: Apr 30 2015
DOI:10.1002/wsbm.1301
Bringing computational models of bone regeneration to the clinic
Advanced Review
Aurélie Carlier, Liesbet Geris, Johan Lammens, Hans Van Oosterwyck
Published Online: Apr 21 2015
DOI:10.1002/wsbm.1299
Integration of systems glycobiology with bioinformatics toolboxes, glycoinformatics resources, and glycoproteomics data
Advanced Review
Gang Liu, Sriram Neelamegham
Published Online: Apr 13 2015
DOI:10.1002/wsbm.1296
Integrative models of vascular remodeling during tumor growth
Advanced Review
Heiko Rieger, Michael Welter
Published Online: Mar 21 2015
DOI:10.1002/wsbm.1295
Systems engineering meets quantitative systems pharmacology: from low‐level targets to engaging the host defenses
Opinion
Ioannis P. Androulakis
Published Online: Mar 16 2015
DOI:10.1002/wsbm.1294
Integrating multi‐scale knowledge on cardiac development into a computational model of ventricular trabeculation
Focus Article
Bouke A. de Boer, Jean‐François Le Garrec, Vincent M. Christoffels, Sigolène M. Meilhac, Jan M. Ruijter
Published Online: Oct 06 2014
DOI:10.1002/wsbm.1285
Tuneable resolution as a systems biology approach for multi‐scale, multi‐compartment computational models
Advanced Review
Denise E. Kirschner, C. Anthony Hunt, Simeone Marino, Mohammad Fallahi‐Sichani, Jennifer J. Linderman
Published Online: Aug 08 2014
DOI:10.1002/wsbm.1270
Cell mechanics: principles, practices, and prospects
Overview
Emad Moeendarbary, Andrew R. Harris
Published Online: Jul 28 2014
DOI:10.1002/wsbm.1275
Boolean modeling: a logic‐based dynamic approach for understanding signaling and regulatory networks and for making useful predictions
Overview
Réka Albert, Juilee Thakar
Published Online: Jul 15 2014
DOI:10.1002/wsbm.1273
Tactile sensory system: encoding from the periphery to the cortex
Focus Article
Lynette A. Jones, Allan M. Smith
Published Online: Mar 19 2014
DOI:10.1002/wsbm.1267
Signaling networks in palate development
Focus Article
Jamie Lane, Vesa Kaartinen
Published Online: Mar 18 2014
DOI:10.1002/wsbm.1265
Modeling the intracellular organization of calcium signaling
Advanced Review
Geneviève Dupont
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1261
Apolipoprotein E receptor pathways in Alzheimer disease
Advanced Review
Vanessa Schmidt, Anne‐Sophie Carlo, Thomas E. Willnow
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1262
Personalizing oncology treatments by predicting drug efficacy, side‐effects, and improved therapy: mathematics, statistics, and their integration
Advanced Review
Zvia Agur, Moran Elishmereni, Yuri Kheifetz
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1263
Glass‐like dynamics in the cell and in cellular collectives
Advanced Review
Monirosadat Sadati, Amir Nourhani, Jeffrey J. Fredberg, Nader Taheri Qazvini
Published Online: Jan 15 2014
DOI:10.1002/wsbm.1258
Advances in modeling ventricular arrhythmias: from mechanisms to the clinic
Focus Article
Natalia A. Trayanova, Patrick M. Boyle
Published Online: Dec 06 2013
DOI:10.1002/wsbm.1256
The structure of dynamic GPCR signaling networks
Focus Article
Patrick R. O'Neill, Lopamudra Giri, W. K. Ajith Karunarathne, Anilkumar K. Patel, K. V. Venkatesh, N. Gautam
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1249
Rule‐based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems
Overview
Lily A. Chylek, Leonard A. Harris, Chang‐Shung Tung, James R. Faeder, Carlos F. Lopez, William S. Hlavacek
Published Online: Sep 30 2013
DOI:10.1002/wsbm.1245
Molecular mechanisms underlying neuronal synaptic plasticity: systems biology meets computational neuroscience in the wilds of synaptic plasticity
Advanced Review
Kim T. Blackwell, Joanna Jedrzejewska‐Szmek
Published Online: Sep 09 2013
DOI:10.1002/wsbm.1240
Integrative approaches for modeling regulation and function of the respiratory system
Overview
Alona Ben‐Tal, Merryn H. Tawhai
Published Online: Sep 09 2013
DOI:10.1002/wsbm.1244
Computational approaches for understanding energy metabolism
Focus Article
Alexander A. Shestov, Brandon Barker, Zhenglong Gu, Jason W. Locasale
Published Online: Jul 29 2013
DOI:10.1002/wsbm.1238
Endothelial cell motility, coordination and pattern formation during vasculogenesis
Advanced Review
Andras Czirok
Published Online: Jul 15 2013
DOI:10.1002/wsbm.1233
Mathematical modeling of kidney transport
Advanced Review
Anita T. Layton
Published Online: Jul 12 2013
DOI:10.1002/wsbm.1232
Multiscale image‐based modeling and simulation of gas flow and particle transport in the human lungs
Focus Article
Ching‐Long Lin, Merryn H. Tawhai, Eric A. Hoffman
Published Online: Jul 10 2013
DOI:10.1002/wsbm.1234
Computational and experimental characterization of skin mechanics: identifying current challenges and future directions
Advanced Review
Jessica W.Y. Jor, Matthew D. Parker, Andrew J. Taberner, Martyn P. Nash, Poul M.F. Nielsen
Published Online: Jun 11 2013
DOI:10.1002/wsbm.1228
A conceptual framework for computational models of Achilles tendon homeostasis
Advanced Review
David W. Smith, Jonas Rubenson, David Lloyd, Minghao Zheng, Justin Fernandez, Thor Besier, Jiake Xu, Bruce S. Gardiner
Published Online: Jun 11 2013
DOI:10.1002/wsbm.1229
Excitable behavior in amoeboid chemotaxis
Focus Article
Changji Shi, Pablo A. Iglesias
Published Online: Jun 11 2013
DOI:10.1002/wsbm.1230
Agent‐based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity
Advanced Review
C. Anthony Hunt, Ryan C. Kennedy, Sean H. J. Kim, Glen E. P. Ropella
Published Online: Jun 04 2013
DOI:10.1002/wsbm.1222
Mathematical modeling of folate metabolism
Focus Article
John C. Panetta, Steven W. Paugh, William E. Evans
Published Online: May 22 2013
DOI:10.1002/wsbm.1227
How changes in fibril‐level organization correlate with the macrolevel behavior of articular cartilage
Focus Article
Mieke Nickien, Ashvin Thambyah, Neil Broom
Published Online: Apr 01 2013
DOI:10.1002/wsbm.1220
Toward a quantitative understanding of the Wnt/β‐catenin pathway through simulation and experiment
Overview
Bethan Lloyd‐Lewis, Alexander G. Fletcher, Trevor C. Dale, Helen M. Byrne
Published Online: Mar 29 2013
DOI:10.1002/wsbm.1221
Toward the virtual stomach: progress in multiscale modeling of gastric electrophysiology and motility
Focus Article
Peng Du, Gregory O'Grady, Jerry Gao, Shameer Sathar, Leo K. Cheng
Published Online: Mar 05 2013
DOI:10.1002/wsbm.1218
Hierarchical approaches for systems modeling in cardiac development
Overview
Russell A. Gould, Lina M. Aboulmouna, Jeffrey D. Varner, Jonathan T. Butcher
Published Online: Mar 05 2013
DOI:10.1002/wsbm.1217
Engineered genetic information processing circuits
Overview
Hao Qi, Andrew Blanchard, Ting Lu
Published Online: Feb 26 2013
DOI:10.1002/wsbm.1216
Mechano‐sensing and transduction by endothelial surface glycocalyx: composition, structure, and function
Focus Article
Bingmei M. Fu, John M. Tarbell
Published Online: Feb 07 2013
DOI:10.1002/wsbm.1211
β‐Arrestin‐kinase scaffolds: turn them on or turn them off?
Focus Article
Alice Lin, Kathryn A. DeFea
Published Online: Jan 14 2013
DOI:10.1002/wsbm.1203
Model‐based design of experiments for cellular processes
Advanced Review
Ankush Chakrabarty, Gregery T. Buzzard, Ann E. Rundell
Published Online: Jan 04 2013
DOI:10.1002/wsbm.1204
Systems biology of lung development and regeneration: current knowledge and recommendations for future research
Opinion
James S. Hagood, Namasivayam Ambalavanan
Published Online: Jan 04 2013
DOI:10.1002/wsbm.1205
Systems analysis of biological networks in skeletal muscle function
Advanced Review
Lucas R. Smith, Gretchen Meyer, Richard L. Lieber
Published Online: Nov 27 2012
DOI:10.1002/wsbm.1197
Accelerating cancer systems biology research through Semantic Web technology
Overview
Thomas S. Deisboeck, Patrick Shironoshita, Thomas Taylor, Jonathan Sagotsky, Zhihui Wang
Published Online: Nov 27 2012
DOI:10.1002/wsbm.1200
Stem cell bioengineering at the interface of systems‐based models and high‐throughput platforms
Overview
Gregory H. Underhill
Published Online: Aug 23 2012
DOI:10.1002/wsbm.1189
Large‐scale mouse knockouts and phenotypes
Advanced Review
Ramiro Ramírez‐Solis, Edward Ryder, Richard Houghton, Jacqueline K. White, Joanna Bottomley
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1183
Post‐translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding
Advanced Review
Guy Lippens, Hanno Steen, Jeremy Gunawardena, Sudhakaran Prabakaran
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1185
From base pair to bedside: molecular simulation and the translation of genomics to personalized medicine
Advanced Review
David W. Wright, Shunzhou Wan, Nour Shublaq, Stefan J. Zasada, Peter V. Coveney
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1186
Mitochondrial network energetics in the heart
Advanced Review
Miguel A. Aon, Sonia Cortassa
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1188
Systems biology of skeletal muscle: fiber type as an organizing principle
Advanced Review
Sarah M. Greising, Heather M. Gransee, Carlos B. Mantilla, Gary C. Sieck
Published Online: Jul 18 2012
DOI:10.1002/wsbm.1184
Decoding the functions of post‐transcriptional regulators in the determination of inflammatory states: focus on macrophage activation
Focus Article
Panagiota Kafasla, Ioannis Karakasiliotis, Dimitris L. Kontoyiannis
Published Online: Jul 03 2012
DOI:10.1002/wsbm.1179
Complexity and the reductionism–holism debate in systems biology
Overview
Fulvio Mazzocchi
Published Online: Jul 03 2012
DOI:10.1002/wsbm.1181
Systems biology approaches to toll‐like receptor signaling
Focus Article
Alexis Vandenbon, Shunsuke Teraguchi, Shizuo Akira, Kiyoshi Takeda, Daron M. Standley
Published Online: Jun 19 2012
DOI:10.1002/wsbm.1178
Hydrogels for in vivo‐like three‐dimensional cellular studies
Advanced Review
Hyun‐Joon Kong, Ross DeVolder
Published Online: May 21 2012
DOI:10.1002/wsbm.1174
Sex and the circuitry: progress toward a systems‐level understanding of vertebrate sex determination
Focus Article
Blanche Capel, Steven C. Munger
Published Online: May 17 2012
DOI:10.1002/wsbm.1172
Deciphering the complexities of human diseases and disorders by coupling induced‐pluripotent stem cells and systems genetics
Advanced Review
William L. Stanford, Janet L. Manias, Kamal Garcha, Wing Y. Chang
Published Online: Apr 10 2012
DOI:10.1002/wsbm.1170
Isotope labeling experiments in metabolomics and fluxomics
Advanced Review
Sebastian Klein, Elmar Heinzle
Published Online: Mar 23 2012
DOI:10.1002/wsbm.1167
Theoretical insights into bacterial chemotaxis
Advanced Review
Marcus J. Tindall, Eamonn A. Gaffney, Philip K. Maini, Judith P. Armitage
Published Online: Mar 12 2012
DOI:10.1002/wsbm.1168
Multiscale models of thrombogenesis
Advanced Review
Zhiliang Xu, Oleg Kim, Malgorzata Kamocka, Elliot D. Rosen, Mark Alber
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1160
The virtual liver: a multidisciplinary, multilevel challenge for systems biology
Overview
Hermann‐Georg Holzhütter, Dirk Drasdo, Tobias Preusser, Jörg Lippert, Adriano M. Henney
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1158
Virtual Cell: computational tools for modeling in cell biology
Advanced Review
Diana C. Resasco, Fei Gao, Frank Morgan, Igor L. Novak, James C. Schaff, Boris M. Slepchenko
Published Online: Dec 02 2011
DOI:10.1002/wsbm.165
Computational models for the study of heart–lung interactions in mammals
Advanced Review
Alona Ben‐Tal
Published Online: Dec 02 2011
DOI:10.1002/wsbm.167
Systems vaccinology: learning to compute the behavior of vaccine induced immunity
Focus Article
Helder I. Nakaya, Shuzhao Li, Bali Pulendran
Published Online: Oct 19 2011
DOI:10.1002/wsbm.163
Modeling of spatially‐restricted intracellular signaling
Focus Article
Susana R. Neves
Published Online: Jul 15 2011
DOI:10.1002/wsbm.155
Mathematical models in biology: from molecules to life
Advanced Review
Yiannis N. Kaznessis
Published Online: Feb 18 2011
DOI:10.1002/wsbm.142
Estrogen receptor‐positive breast cancer: a multidisciplinary challenge
Focus Article
Wilbert Zwart, Vasiliki Theodorou, Jason S. Carroll
Published Online: Feb 08 2011
DOI:10.1002/wsbm.109
Signaling pathways that control cell migration: models and analysis
Focus Article
Erik S. Welf, Jason M. Haugh
Published Online: Feb 08 2011
DOI:10.1002/wsbm.110
A multifaceted approach to modeling the immune response in tuberculosis
Focus Article
Simeone Marino, Jennifer J. Linderman, Denise E. Kirschner
Published Online: Dec 31 2010
DOI:10.1002/wsbm.131
Simulation of cellular biochemical system kinetics
Opinion
Daniel A. Beard
Published Online: Dec 17 2010
DOI:10.1002/wsbm.116
Hybrid models of tumor growth
Focus Article
Katarzyna A. Rejniak, Alexander R. A. Anderson
Published Online: Dec 16 2010
DOI:10.1002/wsbm.102
Electrophysiological models of neural processing
Focus Article
Mark E. Nelson
Published Online: Dec 16 2010
DOI:10.1002/wsbm.95
Calcium dynamics and signaling in vascular regulation: computational models
Focus Article
Nikolaos Michael Tsoukias
Published Online: Dec 16 2010
DOI:10.1002/wsbm.97
Integrative modeling of the cardiac ventricular myocyte
Advanced Review
Raimond L. Winslow, Sonia Cortassa, Brian O'Rourke, Yasmin L. Hashambhoy, John Jeremy Rice, Joseph L. Greenstein
Published Online: Sep 23 2010
DOI:10.1002/wsbm.122
In silico models of bone remodeling from macro to nano—from organ to cell
Focus Article
Duncan Webster, Ralph Müller
Published Online: Aug 25 2010
DOI:10.1002/wsbm.115
Circadian oscillators in eukaryotes
Advanced Review
Ingunn W. Jolma, Ole Didrik Laerum, Cathrine Lillo, Peter Ruoff
Published Online: Aug 04 2010
DOI:10.1002/wsbm.81
Odor representations in the mammalian olfactory bulb
Focus Article
Adil Ghani Khan, K. Parthasarathy, Upinder Singh Bhalla
Published Online: Aug 04 2010
DOI:10.1002/wsbm.85
Modeling of blood flow in arterial trees
Focus Article
Tomer Anor, Leopold Grinberg, Hyoungsu Baek, Joseph R. Madsen, Mahesh V. Jayaraman, George E. Karniadakis
Published Online: Aug 04 2010
DOI:10.1002/wsbm.90
In silico models of cancer
Advanced Review
Lucas B. Edelman, James A. Eddy, Nathan D. Price
Published Online: Jun 15 2010
DOI:10.1002/wsbm.75
Modeling actin dynamics
Focus Article
Mike Bindschadler
Published Online: Jun 15 2010
DOI:10.1002/wsbm.62
Modeling childbirth: elucidating the mechanisms of labor
Focus Article
Xinshan Li, Jennifer A. Kruger, Martyn P. Nash, Poul M.F. Nielsen
Published Online: Jun 15 2010
DOI:10.1002/wsbm.65
Modeling breast biomechanics for multi‐modal image analysis—successes and challenges
Advanced Review
Vijay Rajagopal, Poul M. F. Nielsen, Martyn P. Nash
Published Online: Apr 09 2010
DOI:10.1002/wsbm.58
Evolution of transcriptional regulatory networks in yeast populations
Advanced Review
Duccio Cavalieri
Published Online: Apr 09 2010
DOI:10.1002/wsbm.68
Systems biology of pro‐angiogenic therapies targeting the VEGF system
Focus Article
Feilim Mac Gabhann, Amina A. Qutub, Brian H. Annex, Aleksander S. Popel
Published Online: Apr 07 2010
DOI:10.1002/wsbm.92
Computational modeling of mammalian signaling networks
Advanced Review
Jacob J. Hughey, Timothy K. Lee, Markus W. Covert
Published Online: Mar 26 2010
DOI:10.1002/wsbm.52
Toward a VPH/Physiome ToolKit
Overview
Alan Garny, Jonathan Cooper, Peter J. Hunter
Published Online: Mar 26 2010
DOI:10.1002/wsbm.63
Models at the single cell level
Advanced Review
Raymond Cheong, Saurabh Paliwal, Andre Levchenko
Published Online: Jan 15 2010
DOI:10.1002/wsbm.49
Systems biology of GAL regulon in Saccharomyces cerevisiae
Focus Article
Venkat Reddy Pannala, Paike Jayadeva Bhat, Sharad Bhartiya, K. V. Venkatesh
Published Online: Jan 15 2010
DOI:10.1002/wsbm.38
T cell responses in lymph nodes
Focus Article
Gib Bogle, P. Rod Dunbar
Published Online: Jan 15 2010
DOI:10.1002/wsbm.47
Genome‐scale metabolic networks
Advanced Review
Marco Terzer, Nathaniel D. Maynard, Markus W. Covert, Jörg Stelling
Published Online: Nov 13 2009
DOI:10.1002/wsbm.37
Kidney modeling and systems physiology
Advanced Review
S. Randall Thomas
Published Online: Sep 22 2009
DOI:10.1002/wsbm.14
Computational modeling of epithelial tissues
Advanced Review
Rod Smallwood
Published Online: Sep 22 2009
DOI:10.1002/wsbm.18
Spatial regulation of PI3K signaling during chemotaxis
Focus Article
Pablo A. Iglesias
Published Online: Sep 22 2009
DOI:10.1002/wsbm.13
Regulation of endothelial cell functions by basement membrane‐ and arachidonic acid‐derived products
Focus Article
Ambra Pozzi, Roy Zent
Published Online: Sep 22 2009
DOI:10.1002/wsbm.7
Four‐dimensional dynamics of MAPK information‐processing systems
Advanced Review
Boris N. Kholodenko, Marc R. Birtwistle
Published Online: May 05 2009
DOI:10.1002/wsbm.16
The lung physiome: merging imaging‐based measures with predictive computational models
Advanced Review
Merryn H. Tawhai, Eric A. Hoffman, Ching‐Long Lin
Published Online: May 05 2009
DOI:10.1002/wsbm.17
Design principles of the bacterial quorum sensing gene networks
Advanced Review
Andrew B. Goryachev
Published Online: May 05 2009
DOI:10.1002/wsbm.27
Multiscale systems integration in the eye
Advanced Review
Marc D. Jacobs
Published Online: May 05 2009
DOI:10.1002/wsbm.29