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Mammalian Physiology in Health and Disease

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Calibration of ionic and cellular cardiac electrophysiology models

Advanced Review
Dominic G. Whittaker, Michael Clerx, Chon Lok Lei, David J. Christini, Gary R. Mirams
Published Online: Feb 21 2020
DOI:10.1002/wsbm.1482

Abstract Full article on Wiley Online Library:   HTML | PDF
Glucose transporter 1 in rheumatoid arthritis and autoimmunity

Advanced Review
Ekaterina Zezina, Oezen Sercan‐Alp, Matthias Herrmann, Nadine Biesemann
Published Online: Feb 21 2020
DOI:10.1002/wsbm.1483

Abstract Full article on Wiley Online Library:   HTML | PDF
Single‐cell analysis of CD8 T lymphocyte diversity during adaptive immunity

Focus Article
Janilyn Arsenio
Published Online: Dec 26 2019
DOI:10.1002/wsbm.1475

Abstract Full article on Wiley Online Library:   HTML | PDF
Functional genomic approaches to elucidate the role of enhancers during development

Advanced Review
Genevieve E. Ryan, Emma K. Farley
Published Online: Dec 05 2019
DOI:10.1002/wsbm.1467

Abstract Full article on Wiley Online Library:   HTML | PDF
Network architecture and regulatory logic in neural crest development

Focus Article
Austin S. Hovland, Megan Rothstein, Marcos Simoes‐Costa
Published Online: Nov 08 2019
DOI:10.1002/wsbm.1468

Abstract Full article on Wiley Online Library:   HTML | PDF
Skeletal muscle: A review of molecular structure and function, in health and disease

Advanced Review
Kavitha Mukund, Shankar Subramaniam
Published Online: Aug 13 2019
DOI:10.1002/wsbm.1462

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics

Advanced Review
Oliver Röhrle, Utku Ş. Yavuz, Thomas Klotz, Francesco Negro, Thomas Heidlauf
Published Online: Jun 24 2019
DOI:10.1002/wsbm.1457

Abstract Full article on Wiley Online Library:   HTML | PDF
Neutrophils in innate immunity and systems biology‐level approaches

Update
Viktoria Rungelrath, Scott D. Kobayashi, Frank R. DeLeo
Published Online: Jun 20 2019
DOI:10.1002/wsbm.1458

Abstract Full article on Wiley Online Library:   HTML | PDF
Circadian rhythms and proteomics: It's all about posttranslational modifications!

Focus Article
Daniel Mauvoisin
Published Online: Apr 29 2019
DOI:10.1002/wsbm.1450

Abstract Full article on Wiley Online Library:   HTML | PDF
Essential contributions of enhancer genomic regulatory elements to microglial cell identity and functions

Focus Article
André Machado Xavier, Sarah Belhocine, David Gosselin
Published Online: Apr 23 2019
DOI:10.1002/wsbm.1449

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of robustness and homeostatic mechanisms

Overview
H. Frederik Nijhout, Janet A. Best, Michael C. Reed
Published Online: Oct 29 2018
DOI:10.1002/wsbm.1440

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of circadian rhythms

Focus Article
Ameneh Asgari‐Targhi, Elizabeth B. Klerman
Published Online: Oct 17 2018
DOI:10.1002/wsbm.1439

Abstract Full article on Wiley Online Library:   HTML | PDF
The mammalian mycobiome: A complex system in a dynamic relationship with the host

Advanced Review
Ghee Chuan Lai, Tze Guan Tan, Norman Pavelka
Published Online: Sep 25 2018
DOI:10.1002/wsbm.1438

Abstract Full article on Wiley Online Library:   HTML | PDF
Committing the primordial germ cell: An updated molecular perspective

Advanced Review
Haihan Tan, Wee‐Wei Tee
Published Online: Sep 17 2018
DOI:10.1002/wsbm.1436

Abstract Full article on Wiley Online Library:   HTML | PDF
Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+‐Ca2+‐Ca2+/calmodulin‐dependent protein kinase II‐reactive oxygen species feedback

Focus Article
Stefano Morotti, Eleonora Grandi
Published Online: Jul 17 2018
DOI:10.1002/wsbm.1434

Abstract Full article on Wiley Online Library:   HTML | PDF
Cell cycle regulation of folate‐mediated one‐carbon metabolism

Advanced Review
Patrick J. Stover, Martha S. Field, Xu Lan
Published Online: Jun 11 2018
DOI:10.1002/wsbm.1426

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems approaches to optimizing deep brain stimulation therapies in Parkinson’s disease

Overview
Sridevi V. Sarma, John T. Gale, Sabato Santaniello
Published Online: Mar 20 2018
DOI:10.1002/wsbm.1421

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems analysis of dilated cardiomyopathy in the next generation sequencing era

Focus Article
Magdalena Harakalova, Folkert W. Asselbergs
Published Online: Feb 27 2018
DOI:10.1002/wsbm.1419

Abstract Full article on Wiley Online Library:   HTML | PDF
Human microbiota, blood group antigens, and disease

Advanced Review
D. Rose Ewald, Susan C.J. Sumner
Published Online: Jan 09 2018
DOI:10.1002/wsbm.1413

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of oxygen homeostasis

Advanced Review
Gregg L. Semenza, Nanduri R. Prabhakar, Debangshu Samanta
Published Online: Feb 21 2017
DOI:10.1002/wsbm.1382

Abstract Full article on Wiley Online Library:   HTML | PDF
Traditional and novel tools to probe the mitochondrial metabolism in health and disease

Advanced Review
Yanfei Zhang, José L. Avalos
Published Online: Jan 09 2017
DOI:10.1002/wsbm.1373

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational models of the neural control of breathing

Advanced Review
Jeffrey C. Smith, Ilya A. Rybak, Jonathan E. Rubin, Yaroslav I. Molkov
Published Online: Dec 23 2016
DOI:10.1002/wsbm.1371

Abstract Full article on Wiley Online Library:   HTML | PDF
Cancer and inflammation

Overview
Lance L. Munn
Published Online: Dec 12 2016
DOI:10.1002/wsbm.1370

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of the female reproductive system: from oocyte to delivery

Overview
Alys R Clark, Jennifer A Kruger
Published Online: Sep 09 2016
DOI:10.1002/wsbm.1353

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems physiology of the airways in health and obstructive pulmonary disease

Advanced Review
Jason H.T. Bates
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1347

Abstract Full article on Wiley Online Library:   HTML | PDF
Mitochondrial metabolic remodeling in response to genetic and environmental perturbations

Advanced Review
Kate E.R. Hollinshead, Daniel A. Tennant
Published Online: May 19 2016
DOI:10.1002/wsbm.1334

Abstract Full article on Wiley Online Library:   HTML | PDF
Dynamics of the mammalian cell cycle in physiological and pathological conditions

Focus Article
Claude Gérard, Albert Goldbeter
Published Online: Nov 27 2015
DOI:10.1002/wsbm.1325

Abstract Full article on Wiley Online Library:   HTML | PDF
The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications

Advanced Review
Peng Du, Niranchan Paskaranandavadivel, Timothy R. Angeli, Leo K. Cheng, Gregory O'Grady
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1324

Abstract Full article on Wiley Online Library:   HTML | PDF
Measurement and modeling of coronary blood flow

Overview
Matthew D. Sinclair, Jack Lee, Andrew N. Cookson, Simone Rivolo, Eoin R. Hyde, Nicolas P. Smith
Published Online: Jun 30 2015
DOI:10.1002/wsbm.1309

Abstract Full article on Wiley Online Library:   HTML | PDF
The role of the microbiota in ageing: current state and perspectives

Focus Article
Denise B. Lynch, Ian B. Jeffery, Paul W. O'Toole
Published Online: Mar 16 2015
DOI:10.1002/wsbm.1293

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems engineering meets quantitative systems pharmacology: from low‐level targets to engaging the host defenses

Opinion
Ioannis P. Androulakis
Published Online: Mar 16 2015
DOI:10.1002/wsbm.1294

Abstract Full article on Wiley Online Library:   HTML | PDF
Apolipoprotein E receptor pathways in Alzheimer disease

Advanced Review
Vanessa Schmidt, Anne‐Sophie Carlo, Thomas E. Willnow
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1262

Abstract Full article on Wiley Online Library:   HTML | PDF
Axes of differentiation in breast cancer: untangling stemness, lineage identity, and the epithelial to mesenchymal transition

Advanced Review
Roy Z. Granit, Michal Slyper, Ittai Ben‐Porath
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1252

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative approaches for modeling regulation and function of the respiratory system

Overview
Alona Ben‐Tal, Merryn H. Tawhai
Published Online: Sep 09 2013
DOI:10.1002/wsbm.1244

Abstract Full article on Wiley Online Library:   HTML | PDF
Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter

Overview
Najla Arshad, Sandhya S. Visweswariah
Published Online: Apr 22 2013
DOI:10.1002/wsbm.1223

Abstract Full article on Wiley Online Library:   HTML | PDF
Branched‐chain amino acid supplementation: impact on signaling and relevance to critical illness

Advanced Review
John S. A. Mattick, Kubra Kamisoglu, Marianthi G. Ierapetritou, Ioannis P. Androulakis, Francois Berthiaume
Published Online: Mar 29 2013
DOI:10.1002/wsbm.1219

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling cellular compartmentation in one‐carbon metabolism

Advanced Review
Patrick J. Stover, Emily J. Shearer, Lorenzo Stella, Marco Scotti
Published Online: Feb 13 2013
DOI:10.1002/wsbm.1209

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation

Advanced Review
Sara Manteiga, Kyungoh Choi, Arul Jayaraman, Kyongbum Lee
Published Online: Feb 13 2013
DOI:10.1002/wsbm.1213

Abstract Full article on Wiley Online Library:   HTML | PDF
Can a systems biology approach unlock the mysteries of Kawasaki disease?

Focus Article
Anne H. Rowley
Published Online: Jan 04 2013
DOI:10.1002/wsbm.1202

Abstract Full article on Wiley Online Library:   HTML | PDF
Lymphatic vessels in health and disease

Focus Article
Cristina T. Kesler, Shan Liao, Lance L. Munn, Timothy P. Padera
Published Online: Dec 03 2012
DOI:10.1002/wsbm.1201

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems analysis of biological networks in skeletal muscle function

Advanced Review
Richard L. Lieber, Gretchen Meyer, Lucas R. Smith
Published Online: Nov 27 2012
DOI:10.1002/wsbm.1197

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology approaches to finding novel pain mediators

Advanced Review
David L.H. Bennett, Christine Orengo, Tobias Hildebrandt, Jonathan Lees, James R. Perkins, Ana Antunes‐Martins
Published Online: Oct 11 2012
DOI:10.1002/wsbm.1192

Abstract Full article on Wiley Online Library:   HTML | PDF
Role of fibroblast growth factor signaling in vascular formation and maintenance: orchestrating signaling networks as an integrated system

Focus Article
Takashi Sakurai, Masahiro Murakami
Published Online: Aug 28 2012
DOI:10.1002/wsbm.1190

Abstract Full article on Wiley Online Library:   HTML | PDF
Large‐scale mouse knockouts and phenotypes

Advanced Review
Ramiro Ramírez‐Solis, Edward Ryder, Richard Houghton, Jacqueline K. White, Joanna Bottomley
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1183

Abstract Full article on Wiley Online Library:   HTML | PDF
Mitochondrial network energetics in the heart

Advanced Review
Miguel A. Aon, Sonia Cortassa
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1188

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of skeletal muscle: fiber type as an organizing principle

Advanced Review
Sarah M. Greising, Heather M. Gransee, Carlos B. Mantilla, Gary C. Sieck
Published Online: Jul 18 2012
DOI:10.1002/wsbm.1184

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine

Advanced Review
Joseph Loscalzo, Scott Weiss, Elliott Antman
Published Online: May 11 2012
DOI:10.1002/wsbm.1173

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale models of thrombogenesis

Advanced Review
Zhiliang Xu, Oleg Kim, Malgorzata Kamocka, Elliot D. Rosen, Mark Alber
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1160

Abstract Full article on Wiley Online Library:   HTML | PDF
Normal morphogenesis of epithelial tissues and progression of epithelial tumors

Advanced Review
Chun‐Chao Wang, Leen Jamal, Kevin A. Janes
Published Online: Sep 02 2011
DOI:10.1002/wsbm.159

Abstract Full article on Wiley Online Library:   HTML | PDF
A systems biology approach to synovial joint lubrication in health, injury, and disease

Overview
Alexander Y. Hui, William J. McCarty, Koichi Masuda, Gary S. Firestein, Robert L. Sah
Published Online: Aug 08 2011
DOI:10.1002/wsbm.157

Abstract Full article on Wiley Online Library:   HTML | PDF
Integration of cardiovascular regulation by the blood/endothelium cell‐free layer

Advanced Review
C. Makena Hightower, Beatriz Y. Salazar Vázquez, Sung Woo Park, Krishna Sriram, Judith Martini, Ozlem Yalcin, Amy G. Tsai, Pedro Cabrales, Daniel M. Tartakovsky, Paul C. Johnson, Marcos Intaglietta
Published Online: Apr 26 2011
DOI:10.1002/wsbm.150

Abstract Full article on Wiley Online Library:   HTML | PDF
Heparan sulfate proteoglycans in healthy and diseased systems

Focus Article
John Whitelock, James Melrose
Published Online: Apr 01 2011
DOI:10.1002/wsbm.149

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems physiology—the heart of the matter or a bone of contention?

Editorial Commentary
Shankar Subramaniam, Joseph H. Nadeau
Published Online: Feb 08 2011
DOI:10.1002/wsbm.146

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational systems biology of aging

Advanced Review
Andres Kriete, Mark Lechner, Drew Clearfield, Dirk Bohmann
Published Online: Dec 31 2010
DOI:10.1002/wsbm.126

Abstract Full article on Wiley Online Library:   HTML | PDF
A multifaceted approach to modeling the immune response in tuberculosis

Focus Article
Simeone Marino, Jennifer J. Linderman, Denise E. Kirschner
Published Online: Dec 31 2010
DOI:10.1002/wsbm.131

Abstract Full article on Wiley Online Library:   HTML | PDF
Ischemic kidney injury and mechanisms of tissue repair

Focus Article
Marwa El Sabbahy, Vishal S. Vaidya
Published Online: Dec 31 2010
DOI:10.1002/wsbm.133

Abstract Full article on Wiley Online Library:   HTML | PDF
Live cell imaging and systems biology

Advanced Review
Myong‐Hee Sung, James G. McNally
Published Online: Aug 20 2010
DOI:10.1002/wsbm.108

Abstract Full article on Wiley Online Library:   HTML | PDF
Emerging clinical applications in cardiovascular pharmacogenomics

Advanced Review
Samir B. Damani, Eric J. Topol
Published Online: Aug 20 2010
DOI:10.1002/wsbm.113

Abstract Full article on Wiley Online Library:   HTML | PDF
Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity

Focus Article
Zivjena Vucetic, Teresa M. Reyes
Published Online: Aug 04 2010
DOI:10.1002/wsbm.77

Abstract Full article on Wiley Online Library:   HTML | PDF
Gastrointestinal system

Advanced Review
Leo K. Cheng, Gregory O'Grady, Peng Du, John U. Egbuji, John A. Windsor, Andrew J. Pullan
Published Online: Jan 15 2010
DOI:10.1002/wsbm.19

Abstract Full article on Wiley Online Library:   HTML | PDF
T cell responses in lymph nodes

Focus Article
Gib Bogle, P. Rod Dunbar
Published Online: Jan 15 2010
DOI:10.1002/wsbm.47

Abstract Full article on Wiley Online Library:   HTML | PDF
Chronic lung diseases

Advanced Review
Wei Wu, Naftali Kaminski
Published Online: Nov 13 2009
DOI:10.1002/wsbm.23

Abstract Full article on Wiley Online Library:   HTML | PDF
Kidney modeling and systems physiology

Advanced Review
S. Randall Thomas
Published Online: Sep 22 2009
DOI:10.1002/wsbm.14

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems Biology and Physiome Projects

Editorial Commentary
Aleksander S. Popel, Peter J. Hunter
Published Online: Sep 22 2009
DOI:10.1002/wsbm.67

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems analysis of bone

Advanced Review
Karl J. Jepsen
Published Online: May 05 2009
DOI:10.1002/wsbm.15

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale systems integration in the eye

Advanced Review
Marc D. Jacobs
Published Online: May 05 2009
DOI:10.1002/wsbm.29

Abstract Full article on Wiley Online Library:   HTML | PDF
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