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Cell Signaling

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Regulating cellular cyclic adenosine monophosphate: “Sources,” “sinks,” and now, “tunable valves”

Focus Article
Michael Getz, Padmini Rangamani, Pradipta Ghosh
Published Online: Apr 23 2020
DOI:10.1002/wsbm.1490

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling immune cell behavior across scales in cancer

Advanced Review
Sahak Z. Makaryan, Colin G. Cess, Stacey D. Finley
Published Online: Mar 04 2020
DOI:10.1002/wsbm.1484

Abstract Full article on Wiley Online Library:   HTML | PDF
The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity

Advanced Review
Michael D. Kornberg
Published Online: Feb 27 2020
DOI:10.1002/wsbm.1486

Abstract Full article on Wiley Online Library:   HTML | PDF
Intracellular signaling dynamics and their role in coordinating tissue repair

Focus Article
Samuel J. Ghilardi, Breanna M. O'Reilly, Allyson E. Sgro
Published Online: Feb 08 2020
DOI:10.1002/wsbm.1479

Abstract Full article on Wiley Online Library:   HTML | PDF
Growth control in the Drosophila wing disk

Advanced Review
Jia Gou, Jay A. Stotsky, Hans G. Othmer
Published Online: Jan 09 2020
DOI:10.1002/wsbm.1478

Abstract Full article on Wiley Online Library:   HTML | PDF
IL7 receptor signaling in T cells: A mathematical modeling perspective

Overview
Jung‐Hyun Park, Adam T. Waickman, Joseph Reynolds, Mario Castro, Carmen Molina‐París
Published Online: May 28 2019
DOI:10.1002/wsbm.1447

Abstract Full article on Wiley Online Library:   HTML | PDF
Circadian rhythms and proteomics: It's all about posttranslational modifications!

Focus Article
Daniel Mauvoisin
Published Online: Apr 29 2019
DOI:10.1002/wsbm.1450

Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium signals that determine vascular resistance

Focus Article
Matteo Ottolini, Kwangseok Hong, Swapnil K. Sonkusare
Published Online: Mar 18 2019
DOI:10.1002/wsbm.1448

Abstract Full article on Wiley Online Library:   HTML | PDF
Towards multiscale modeling of the CD8+ T cell response to viral infections

Advanced Review
Subhasish Baral, Rubesh Raja, Pramita Sen, Narendra M. Dixit
Published Online: Feb 27 2019
DOI:10.1002/wsbm.1446

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrating molecular networks with genetic variant interpretation for precision medicine

Overview
Hannah Carter, Kivilcim Ozturk, Emidio Capriotti
Published Online: Dec 12 2018
DOI:10.1002/wsbm.1443

Abstract Full article on Wiley Online Library:   HTML | PDF
Context‐dependent regulation of receptor tyrosine kinases: Insights from systems biology approaches

Focus Article
Inez Lam, Christina M. Pickering, Feilim Mac Gabhann
Published Online: Sep 26 2018
DOI:10.1002/wsbm.1437

Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanisms of Wnt signaling and control

Overview
Stephanie Grainger, Karl Willert
Published Online: Mar 30 2018
DOI:10.1002/wsbm.1422

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of cellular membranes: a convergence with biophysics

Advanced Review
Morgan Chabanon, Jeanne C. Stachowiak, Padmini Rangamani
Published Online: May 05 2017
DOI:10.1002/wsbm.1386

Abstract Full article on Wiley Online Library:   HTML | PDF
Understanding the mTOR signaling pathway via mathematical modeling

Advanced Review
Nurgazy Sulaimanov, Martin Klose, Hauke Busch, Melanie Boerries
Published Online: Feb 10 2017
DOI:10.1002/wsbm.1379

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling, signaling and cytoskeleton dynamics: integrated modeling‐experimental frameworks in cell migration

Advanced Review
Meng Sun, Muhammad H. Zaman
Published Online: Nov 15 2016
DOI:10.1002/wsbm.1365

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial

Advanced Review
Nicoletta Castagnino, Massimo Maffei, Lorenzo Tortolina, Gabriele Zoppoli, Daniela Piras, Alessio Nencioni, Eva Moran, Alberto Ballestrero, Franco Patrone, Silvio Parodi
Published Online: May 30 2016
DOI:10.1002/wsbm.1342

Abstract Full article on Wiley Online Library:   HTML | PDF
Signaling via the NFκB system

Advanced Review
Simon Mitchell, Jesse Vargas, Alexander Hoffmann
Published Online: Mar 16 2016
DOI:10.1002/wsbm.1331

Abstract Full article on Wiley Online Library:   HTML | PDF
Heart valve regeneration: the need for systems approaches

Focus Article
Jenna Usprech, Wen Li Kelly Chen, Craig A. Simmons
Published Online: Feb 09 2016
DOI:10.1002/wsbm.1329

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte

Advanced Review
Raimond L. Winslow, Mark A. Walker, Joseph L. Greenstein
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1322

Abstract Full article on Wiley Online Library:   HTML | PDF
Implementation of integral feedback control in biological systems

Advanced Review
Pramod R. Somvanshi, Anilkumar K. Patel, Sharad Bhartiya, K. V. Venkatesh
Published Online: Jun 02 2015
DOI:10.1002/wsbm.1307

Abstract Full article on Wiley Online Library:   HTML | PDF
Topology, dynamics, and heterogeneity in immune signaling

Advanced Review
J. Taylor Webb, Marcelo Behar
Published Online: May 27 2015
DOI:10.1002/wsbm.1306

Abstract Full article on Wiley Online Library:   HTML | PDF
The cell as the mechanistic basis for evolution

Advanced Review
J.S. Torday
Published Online: May 25 2015
DOI:10.1002/wsbm.1305

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrating omics into the cardiac differentiation of human pluripotent stem cells

Focus Article
Agustin Rojas‐Muñoz, Mano R. Maurya, Frederick Lo, Erik Willems
Published Online: Aug 08 2014
DOI:10.1002/wsbm.1268

Abstract Full article on Wiley Online Library:   HTML | PDF
Boolean modeling: a logic‐based dynamic approach for understanding signaling and regulatory networks and for making useful predictions

Overview
Réka Albert, Juilee Thakar
Published Online: Jul 15 2014
DOI:10.1002/wsbm.1273

Abstract Full article on Wiley Online Library:   HTML | PDF
Signaling networks in palate development

Focus Article
Jamie Lane, Vesa Kaartinen
Published Online: Mar 18 2014
DOI:10.1002/wsbm.1265

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling the intracellular organization of calcium signaling

Advanced Review
Geneviève Dupont
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1261

Abstract Full article on Wiley Online Library:   HTML | PDF
The structure of dynamic GPCR signaling networks

Focus Article
Patrick R. O'Neill, Lopamudra Giri, W. K. Ajith Karunarathne, Anilkumar K. Patel, K. V. Venkatesh, N. Gautam
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1249

Abstract Full article on Wiley Online Library:   HTML | PDF
Rule‐based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems

Overview
Lily A. Chylek, Leonard A. Harris, Chang‐Shung Tung, James R. Faeder, Carlos F. Lopez, William S. Hlavacek
Published Online: Sep 30 2013
DOI:10.1002/wsbm.1245

Abstract Full article on Wiley Online Library:   HTML | PDF
Molecular mechanisms underlying neuronal synaptic plasticity: systems biology meets computational neuroscience in the wilds of synaptic plasticity

Advanced Review
Kim T. Blackwell, Joanna Jedrzejewska‐Szmek
Published Online: Sep 09 2013
DOI:10.1002/wsbm.1240

Abstract Full article on Wiley Online Library:   HTML | PDF
Excitable behavior in amoeboid chemotaxis

Focus Article
Changji Shi, Pablo A. Iglesias
Published Online: Jun 11 2013
DOI:10.1002/wsbm.1230

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Cell‐specific integration of nuclear receptor function at the genome

Focus Article
Logan J. Everett, Mitchell A. Lazar
Published Online: Jun 11 2013
DOI:10.1002/wsbm.1231

Abstract Full article on Wiley Online Library:   HTML | PDF
Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter

Overview
Najla Arshad, Sandhya S. Visweswariah
Published Online: Apr 22 2013
DOI:10.1002/wsbm.1223

Abstract Full article on Wiley Online Library:   HTML | PDF
Riding the crest of the wave: parallels between the neural crest and cancer in epithelial‐to‐mesenchymal transition and migration

Focus Article
Davalyn R. Powell, Alex J. Blasky, Steven G. Britt, Kristin B. Artinger
Published Online: Apr 10 2013
DOI:10.1002/wsbm.1224

Abstract Full article on Wiley Online Library:   HTML | PDF
Toward a quantitative understanding of the Wnt/β‐catenin pathway through simulation and experiment

Overview
Bethan Lloyd‐Lewis, Alexander G. Fletcher, Trevor C. Dale, Helen M. Byrne
Published Online: Mar 29 2013
DOI:10.1002/wsbm.1221

Abstract Full article on Wiley Online Library:   HTML | PDF
Mechano‐sensing and transduction by endothelial surface glycocalyx: composition, structure, and function

Focus Article
Bingmei M. Fu, John M. Tarbell
Published Online: Feb 07 2013
DOI:10.1002/wsbm.1211

Abstract Full article on Wiley Online Library:   HTML | PDF
β‐Arrestin‐kinase scaffolds: turn them on or turn them off?

Focus Article
Alice Lin, Kathryn A. DeFea
Published Online: Jan 14 2013
DOI:10.1002/wsbm.1203

Abstract Full article on Wiley Online Library:   HTML | PDF
Model‐based design of experiments for cellular processes

Advanced Review
Ankush Chakrabarty, Gregery T. Buzzard, Ann E. Rundell
Published Online: Jan 04 2013
DOI:10.1002/wsbm.1204

Abstract Full article on Wiley Online Library:   HTML | PDF
The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation

Focus Article
Rebekah R. Bartelt, Jon C. D. Houtman
Published Online: Nov 13 2012
DOI:10.1002/wsbm.1194

Abstract Full article on Wiley Online Library:   HTML | PDF
Toward a systems‐level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile

Focus Article
Pamela V. Tran, Salil A. Lachke, Rolf W. Stottmann
Published Online: Oct 11 2012
DOI:10.1002/wsbm.1193

Abstract Full article on Wiley Online Library:   HTML | PDF
Role of fibroblast growth factor signaling in vascular formation and maintenance: orchestrating signaling networks as an integrated system

Focus Article
Masahiro Murakami, Takashi Sakurai
Published Online: Aug 28 2012
DOI:10.1002/wsbm.1190

Abstract Full article on Wiley Online Library:   HTML | PDF
The molecular circuitry underlying pluripotency in embryonic stem cells

Advanced Review
Aryeh Warmflash, Brigitte L. Arduini, Ali H. Brivanlou
Published Online: Jul 03 2012
DOI:10.1002/wsbm.1182

Abstract Full article on Wiley Online Library:   HTML | PDF
Decoding the functions of post‐transcriptional regulators in the determination of inflammatory states: focus on macrophage activation

Focus Article
Panagiota Kafasla, Ioannis Karakasiliotis, Dimitris L. Kontoyiannis
Published Online: Jul 03 2012
DOI:10.1002/wsbm.1179

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology approaches to toll‐like receptor signaling

Focus Article
Alexis Vandenbon, Shunsuke Teraguchi, Shizuo Akira, Kiyoshi Takeda, Daron M. Standley
Published Online: Jun 19 2012
DOI:10.1002/wsbm.1178

Abstract Full article on Wiley Online Library:   HTML | PDF
Theoretical insights into bacterial chemotaxis

Advanced Review
Marcus J. Tindall, Eamonn A. Gaffney, Philip K. Maini, Judith P. Armitage
Published Online: Mar 12 2012
DOI:10.1002/wsbm.1168

Abstract Full article on Wiley Online Library:   HTML | PDF
Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers

Focus Article
Eric M. Balzer, Konstantinos Konstantopoulos
Published Online: Sep 12 2011
DOI:10.1002/wsbm.160

Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanistic modeling to investigate signaling by oncogenic Ras mutants

Focus Article
Edward C. Stites, Kodi S. Ravichandran
Published Online: Jul 15 2011
DOI:10.1002/wsbm.156

Abstract Full article on Wiley Online Library:   HTML | PDF
Lipid‐sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome

Advanced Review
Michele Vacca, Chiara Degirolamo, Renato Mariani‐Costantini, Giuseppe Palasciano, Antonio Moschetta
Published Online: Feb 16 2011
DOI:10.1002/wsbm.137

Abstract Full article on Wiley Online Library:   HTML | PDF
Signaling pathways that control cell migration: models and analysis

Focus Article
Erik S. Welf, Jason M. Haugh
Published Online: Feb 08 2011
DOI:10.1002/wsbm.110

Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium dynamics and signaling in vascular regulation: computational models

Focus Article
Nikolaos Michael Tsoukias
Published Online: Dec 16 2010
DOI:10.1002/wsbm.97

Abstract Full article on Wiley Online Library:   HTML | PDF
Live cell imaging and systems biology

Advanced Review
Myong‐Hee Sung, James G. McNally
Published Online: Aug 20 2010
DOI:10.1002/wsbm.108

Abstract Full article on Wiley Online Library:   HTML | PDF
Phosphoproteomics

Overview
Nurhan Ozlu, Bikem Akten, Wiebke Timm, Nathan Haseley, Hanno Steen, Judith A.J. Steen
Published Online: Apr 09 2010
DOI:10.1002/wsbm.41

Abstract Full article on Wiley Online Library:   HTML | PDF
Gene networks for nitrogen sensing, signaling, and response in Arabidopsis thaliana

Focus Article
Elena A. Vidal, Karem P. Tamayo, Rodrigo A. Gutierrez
Published Online: Mar 24 2010
DOI:10.1002/wsbm.87

Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanotransduction: a major regulator of homeostasis and development

Overview
Kevin S. Kolahi, Mohammad R.K. Mofrad
Published Online: Mar 24 2010
DOI:10.1002/wsbm.79

Abstract Full article on Wiley Online Library:   HTML | PDF
The secret codes of mammalian scents

Overview
David M. Ferrero, Stephen D. Liberles
Published Online: Jan 15 2010
DOI:10.1002/wsbm.39

Abstract Full article on Wiley Online Library:   HTML | PDF
NF‐κB signaling

Focus Article
Ellen O'Dea, Alexander Hoffmann
Published Online: May 05 2009
DOI:10.1002/wsbm.30

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrin activation in the immune system

Focus Article
Carlo Laudanna, Matteo Bolomini‐Vittori
Published Online: May 05 2009
DOI:10.1002/wsbm.9

Abstract Full article on Wiley Online Library:   HTML | PDF
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