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Mechanistic Models

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Multiscale modeling methods in biomechanics

Advanced Review
Pinaki Bhattacharya, Marco Viceconti
Published Online: Jan 19 2017
DOI:10.1002/wsbm.1375

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of the female reproductive system: from oocyte to delivery

Overview
Alys R Clark, Jennifer A Kruger
Published Online: Sep 09 2016
DOI:10.1002/wsbm.1353

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems‐level airway models of bronchoconstriction

Focus Article
Graham M. Donovan
Published Online: Jun 27 2016
DOI:10.1002/wsbm.1349

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling of brain dynamics: from single neurons and networks to mathematical tools

Advanced Review
Constantinos Siettos, Jens Starke
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1348

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical models of breast and ovarian cancers

Advanced Review
Dana‐Adriana Botesteanu, Stanley Lipkowitz, Jung‐Min Lee, Doron Levy
Published Online: Jun 03 2016
DOI:10.1002/wsbm.1343

Abstract Full article on Wiley Online Library:   HTML | PDF
Signaling via the NFκB system

Advanced Review
Simon Mitchell, Jesse Vargas, Alexander Hoffmann
Published Online: Mar 16 2016
DOI:10.1002/wsbm.1331

Abstract Full article on Wiley Online Library:   HTML | PDF
Aging and computational systems biology

Advanced Review
Mark T. Mc Auley, Amy E. Morgan, Kathleen M. Mooney
Published Online: Jan 29 2016
DOI:10.1002/wsbm.1328

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling microcirculatory blood flow: current state and future perspectives

Focus Article
Dmitry A. Fedosov, Gerhard Gompper
Published Online: Dec 22 2015
DOI:10.1002/wsbm.1326

Abstract Full article on Wiley Online Library:   HTML | PDF
Dynamics of the mammalian cell cycle in physiological and pathological conditions

Focus Article
Claude Gérard, Albert Goldbeter
Published Online: Nov 27 2015
DOI:10.1002/wsbm.1325

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte

Advanced Review
Raimond L. Winslow, Mark A. Walker, Joseph L. Greenstein
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1322

Abstract Full article on Wiley Online Library:   HTML | PDF
The macrophage and its role in inflammation and tissue repair: mathematical and systems biology approaches

Focus Article
Joanne L. Dunster
Published Online: Oct 13 2015
DOI:10.1002/wsbm.1320

Abstract Full article on Wiley Online Library:   HTML | PDF
Topology, dynamics, and heterogeneity in immune signaling

Advanced Review
J. Taylor Webb, Marcelo Behar
Published Online: May 27 2015
DOI:10.1002/wsbm.1306

Abstract Full article on Wiley Online Library:   HTML | PDF
The cell as the mechanistic basis for evolution

Advanced Review
J.S. Torday
Published Online: May 25 2015
DOI:10.1002/wsbm.1305

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of host–microbe metabolomics

Advanced Review
Almut Heinken, Ines Thiele
Published Online: Apr 30 2015
DOI:10.1002/wsbm.1301

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative models of vascular remodeling during tumor growth

Advanced Review
Heiko Rieger, Michael Welter
Published Online: Mar 21 2015
DOI:10.1002/wsbm.1295

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems engineering meets quantitative systems pharmacology: from low‐level targets to engaging the host defenses

Opinion
Ioannis P. Androulakis
Published Online: Mar 16 2015
DOI:10.1002/wsbm.1294

Abstract Full article on Wiley Online Library:   HTML | PDF
Tuneable resolution as a systems biology approach for multi‐scale, multi‐compartment computational models

Advanced Review
Denise E. Kirschner, C. Anthony Hunt, Simeone Marino, Mohammad Fallahi‐Sichani, Jennifer J. Linderman
Published Online: Aug 08 2014
DOI:10.1002/wsbm.1270

Abstract Full article on Wiley Online Library:   HTML | PDF
Cell mechanics: principles, practices, and prospects

Overview
Emad Moeendarbary, Andrew R. Harris
Published Online: Jul 28 2014
DOI:10.1002/wsbm.1275

Abstract Full article on Wiley Online Library:   HTML | PDF
Boolean modeling: a logic‐based dynamic approach for understanding signaling and regulatory networks and for making useful predictions

Overview
Réka Albert, Juilee Thakar
Published Online: Jul 15 2014
DOI:10.1002/wsbm.1273

Abstract Full article on Wiley Online Library:   HTML | PDF
Personalizing oncology treatments by predicting drug efficacy, side‐effects, and improved therapy: mathematics, statistics, and their integration

Advanced Review
Zvia Agur, Moran Elishmereni, Yuri Kheifetz
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1263

Abstract Full article on Wiley Online Library:   HTML | PDF
Glass‐like dynamics in the cell and in cellular collectives

Advanced Review
Monirosadat Sadati, Amir Nourhani, Jeffrey J. Fredberg, Nader Taheri Qazvini
Published Online: Jan 15 2014
DOI:10.1002/wsbm.1258

Abstract Full article on Wiley Online Library:   HTML | PDF
The structure of dynamic GPCR signaling networks

Focus Article
Patrick R. O'Neill, Lopamudra Giri, W. K. Ajith Karunarathne, Anilkumar K. Patel, K. V. Venkatesh, N. Gautam
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1249

Abstract Full article on Wiley Online Library:   HTML | PDF
Rule‐based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems

Overview
Lily A. Chylek, Leonard A. Harris, Chang‐Shung Tung, James R. Faeder, Carlos F. Lopez, William S. Hlavacek
Published Online: Sep 30 2013
DOI:10.1002/wsbm.1245

Abstract Full article on Wiley Online Library:   HTML | PDF
Molecular mechanisms underlying neuronal synaptic plasticity: systems biology meets computational neuroscience in the wilds of synaptic plasticity

Advanced Review
Kim T. Blackwell, Joanna Jedrzejewska‐Szmek
Published Online: Sep 09 2013
DOI:10.1002/wsbm.1240

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative approaches for modeling regulation and function of the respiratory system

Overview
Alona Ben‐Tal, Merryn H. Tawhai
Published Online: Sep 09 2013
DOI:10.1002/wsbm.1244

Abstract Full article on Wiley Online Library:   HTML | PDF
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