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WIREs Syst Biol Med
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Mechanistic Models

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Computational approaches for understanding energy metabolism

Focus Article
Alexander A. Shestov, Brandon Barker, Zhenglong Gu, Jason W. Locasale
Published Online: Jul 29 2013
DOI:10.1002/wsbm.1238

Abstract Full article on Wiley Online Library:   HTML | PDF
Agent‐based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity

Advanced Review
C. Anthony Hunt, Ryan C. Kennedy, Sean H. J. Kim, Glen E. P. Ropella
Published Online: Jun 04 2013
DOI:10.1002/wsbm.1222

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of folate metabolism

Focus Article
John C. Panetta, Steven W. Paugh, William E. Evans
Published Online: May 22 2013
DOI:10.1002/wsbm.1227

Abstract Full article on Wiley Online Library:   HTML | PDF
Toward a quantitative understanding of the Wnt/β‐catenin pathway through simulation and experiment

Overview
Bethan Lloyd‐Lewis, Alexander G. Fletcher, Trevor C. Dale, Helen M. Byrne
Published Online: Mar 29 2013
DOI:10.1002/wsbm.1221

Abstract Full article on Wiley Online Library:   HTML | PDF
Engineered genetic information processing circuits

Overview
Hao Qi, Andrew Blanchard, Ting Lu
Published Online: Feb 26 2013
DOI:10.1002/wsbm.1216

Abstract Full article on Wiley Online Library:   HTML | PDF
β‐Arrestin‐kinase scaffolds: turn them on or turn them off?

Focus Article
Alice Lin, Kathryn A. DeFea
Published Online: Jan 14 2013
DOI:10.1002/wsbm.1203

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems analysis of biological networks in skeletal muscle function

Advanced Review
Lucas R. Smith, Gretchen Meyer, Richard L. Lieber
Published Online: Nov 27 2012
DOI:10.1002/wsbm.1197

Abstract Full article on Wiley Online Library:   HTML | PDF
Accelerating cancer systems biology research through Semantic Web technology

Overview
Zhihui Wang, Jonathan Sagotsky, Thomas Taylor, Patrick Shironoshita, Thomas S. Deisboeck
Published Online: Nov 27 2012
DOI:10.1002/wsbm.1200

Abstract Full article on Wiley Online Library:   HTML | PDF
Post‐translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding

Advanced Review
Sudhakaran Prabakaran, Guy Lippens, Hanno Steen, Jeremy Gunawardena
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1185

Abstract Full article on Wiley Online Library:   HTML | PDF
From base pair to bedside: molecular simulation and the translation of genomics to personalized medicine

Advanced Review
David W. Wright, Shunzhou Wan, Nour Shublaq, Stefan J. Zasada, Peter V. Coveney
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1186

Abstract Full article on Wiley Online Library:   HTML | PDF
Complexity and the reductionism–holism debate in systems biology

Overview
Fulvio Mazzocchi
Published Online: Jul 03 2012
DOI:10.1002/wsbm.1181

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology approaches to toll‐like receptor signaling

Focus Article
Alexis Vandenbon, Shunsuke Teraguchi, Shizuo Akira, Kiyoshi Takeda, Daron M. Standley
Published Online: Jun 19 2012
DOI:10.1002/wsbm.1178

Abstract Full article on Wiley Online Library:   HTML | PDF
Theoretical insights into bacterial chemotaxis

Advanced Review
Marcus J. Tindall, Eamonn A. Gaffney, Philip K. Maini, Judith P. Armitage
Published Online: Mar 12 2012
DOI:10.1002/wsbm.1168

Abstract Full article on Wiley Online Library:   HTML | PDF
The virtual liver: a multidisciplinary, multilevel challenge for systems biology

Overview
Hermann‐Georg Holzhütter, Dirk Drasdo, Tobias Preusser, Jörg Lippert, Adriano M. Henney
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1158

Abstract Full article on Wiley Online Library:   HTML | PDF
Virtual Cell: computational tools for modeling in cell biology

Advanced Review
Diana C. Resasco, Fei Gao, Frank Morgan, Igor L. Novak, James C. Schaff, Boris M. Slepchenko
Published Online: Dec 02 2011
DOI:10.1002/wsbm.165

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling of spatially‐restricted intracellular signaling

Focus Article
Susana R. Neves
Published Online: Jul 15 2011
DOI:10.1002/wsbm.155

Abstract Full article on Wiley Online Library:   HTML | PDF
A multifaceted approach to modeling the immune response in tuberculosis

Focus Article
Simeone Marino, Jennifer J. Linderman, Denise E. Kirschner
Published Online: Dec 31 2010
DOI:10.1002/wsbm.131

Abstract Full article on Wiley Online Library:   HTML | PDF
Electrophysiological models of neural processing

Focus Article
Mark E. Nelson
Published Online: Dec 16 2010
DOI:10.1002/wsbm.95

Abstract Full article on Wiley Online Library:   HTML | PDF
Odor representations in the mammalian olfactory bulb

Focus Article
Adil Ghani Khan, K. Parthasarathy, Upinder Singh Bhalla
Published Online: Aug 04 2010
DOI:10.1002/wsbm.85

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling childbirth: elucidating the mechanisms of labor

Focus Article
Xinshan Li, Jennifer A. Kruger, Martyn P. Nash, Poul M.F. Nielsen
Published Online: Jun 15 2010
DOI:10.1002/wsbm.65

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling breast biomechanics for multi‐modal image analysis—successes and challenges

Advanced Review
Vijay Rajagopal, Poul M. F. Nielsen, Martyn P. Nash
Published Online: Apr 09 2010
DOI:10.1002/wsbm.58

Abstract Full article on Wiley Online Library:   HTML | PDF
Spatial regulation of PI3K signaling during chemotaxis

Focus Article
Pablo A. Iglesias
Published Online: Sep 22 2009
DOI:10.1002/wsbm.13

Abstract Full article on Wiley Online Library:   HTML | PDF
Four‐dimensional dynamics of MAPK information‐processing systems

Advanced Review
Boris N. Kholodenko, Marc R. Birtwistle
Published Online: May 05 2009
DOI:10.1002/wsbm.16

Abstract Full article on Wiley Online Library:   HTML | PDF
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