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Organ, Tissue, and Physiological Models

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Intracellular signaling dynamics and their role in coordinating tissue repair

Focus Article
Samuel J. Ghilardi, Breanna M. O'Reilly, Allyson E. Sgro
Published Online: Feb 08 2020
DOI:10.1002/wsbm.1479

Abstract Full article on Wiley Online Library:   HTML | PDF
How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post‐infarction patients

Advanced Review
Natalia A. Trayanova, Ashish N. Doshi, Adityo Prakosa
Published Online: Jan 09 2020
DOI:10.1002/wsbm.1477

Abstract Full article on Wiley Online Library:   HTML | PDF
Exploring cardiac form and function: A length‐scale computational biology approach

Advanced Review
William F. Sherman, Anna Grosberg
Published Online: Dec 02 2019
DOI:10.1002/wsbm.1470

Abstract Full article on Wiley Online Library:   HTML | PDF
Hybrid modeling frameworks of tumor development and treatment

Update
Ibrahim M. Chamseddine, Katarzyna A. Rejniak
Published Online: Jul 17 2019
DOI:10.1002/wsbm.1461

Abstract Full article on Wiley Online Library:   HTML | PDF
Agent‐based models of inflammation in translational systems biology: A decade later

Update
Yoram Vodovotz, Gary An
Published Online: Jul 01 2019
DOI:10.1002/wsbm.1460

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics

Advanced Review
Oliver Röhrle, Utku Ş. Yavuz, Thomas Klotz, Francesco Negro, Thomas Heidlauf
Published Online: Jun 24 2019
DOI:10.1002/wsbm.1457

Abstract Full article on Wiley Online Library:   HTML | PDF
IL7 receptor signaling in T cells: A mathematical modeling perspective

Overview
Jung‐Hyun Park, Adam T. Waickman, Joseph Reynolds, Mario Castro, Carmen Molina‐París
Published Online: May 28 2019
DOI:10.1002/wsbm.1447

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of circadian rhythms

Focus Article
Ameneh Asgari‐Targhi, Elizabeth B. Klerman
Published Online: Oct 17 2018
DOI:10.1002/wsbm.1439

Abstract Full article on Wiley Online Library:   HTML | PDF
Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+‐Ca2+‐Ca2+/calmodulin‐dependent protein kinase II‐reactive oxygen species feedback

Focus Article
Stefano Morotti, Eleonora Grandi
Published Online: Jul 17 2018
DOI:10.1002/wsbm.1434

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational anatomy and diffeomorphometry: A dynamical systems model of neuroanatomy in the soft condensed matter continuum

Advanced Review
Michael I. Miller, Sylvain Arguillère, Daniel J. Tward, Laurent Younes
Published Online: Jun 04 2018
DOI:10.1002/wsbm.1425

Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐scale metabolic models applied to human health and disease

Advanced Review
Jens Nielsen, Daniel J Cook
Published Online: Jun 23 2017
DOI:10.1002/wsbm.1393

Abstract Full article on Wiley Online Library:   HTML | PDF
Image‐based computational fluid dynamics in the lung: virtual reality or new clinical practice?

Advanced Review
Haribalan Kumar, Jan De Backer, Kelly S. Burrowes
Published Online: Jun 13 2017
DOI:10.1002/wsbm.1392

Abstract Full article on Wiley Online Library:   HTML | PDF
Biomechanics of the human uterus

Focus Article
Kristin M. Myers, David Elad
Published Online: May 12 2017
DOI:10.1002/wsbm.1388

Abstract Full article on Wiley Online Library:   HTML | PDF
Recent lab‐on‐chip developments for novel drug discovery

Opinion
Mitsutoshi Nakajima, Isao Kobayashi, Nauman Khalid
Published Online: Feb 17 2017
DOI:10.1002/wsbm.1381

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling methods in biomechanics

Advanced Review
Pinaki Bhattacharya, Marco Viceconti
Published Online: Jan 19 2017
DOI:10.1002/wsbm.1375

Abstract Full article on Wiley Online Library:   HTML | PDF
Toward modeling locomotion using electromyography‐informed 3D models: application to cerebral palsy

Focus Article
M. Sartori, J. W. Fernandez, L. Modenese, C. P. Carty, L. A. Barber, K. Oberhofer, J. Zhang, G. G. Handsfield, N. S. Stott, T. F. Besier, D. Farina, D. G. Lloyd
Published Online: Dec 21 2016
DOI:10.1002/wsbm.1368

Abstract Full article on Wiley Online Library:   HTML | PDF
In silico bone mechanobiology: modeling a multifaceted biological system

Advanced Review
Mario Giorgi, Stefaan W. Verbruggen, Damien Lacroix
Published Online: Sep 07 2016
DOI:10.1002/wsbm.1356

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling the second stage of labor

Focus Article
Xiani Yan, Jennifer A. Kruger, Xinshan Li, Poul M. F. Nielsen, Martyn P. Nash
Published Online: Aug 25 2016
DOI:10.1002/wsbm.1351

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems‐level airway models of bronchoconstriction

Focus Article
Graham M. Donovan
Published Online: Jun 27 2016
DOI:10.1002/wsbm.1349

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems physiology of the airways in health and obstructive pulmonary disease

Advanced Review
Jason H.T. Bates
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1347

Abstract Full article on Wiley Online Library:   HTML | PDF
Heart valve regeneration: the need for systems approaches

Focus Article
Jenna Usprech, Wen Li Kelly Chen, Craig A. Simmons
Published Online: Feb 09 2016
DOI:10.1002/wsbm.1329

Abstract Full article on Wiley Online Library:   HTML | PDF
The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications

Advanced Review
Peng Du, Niranchan Paskaranandavadivel, Timothy R. Angeli, Leo K. Cheng, Gregory O'Grady
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1324

Abstract Full article on Wiley Online Library:   HTML | PDF
In search for symmetries in the metabolism of cancer

Advanced Review
Francesco Gatto, Jens Nielsen
Published Online: Nov 05 2015
DOI:10.1002/wsbm.1321

Abstract Full article on Wiley Online Library:   HTML | PDF
Measurement and modeling of coronary blood flow

Overview
Matthew D. Sinclair, Jack Lee, Andrew N. Cookson, Simone Rivolo, Eoin R. Hyde, Nicolas P. Smith
Published Online: Jun 30 2015
DOI:10.1002/wsbm.1309

Abstract Full article on Wiley Online Library:   HTML | PDF
The cell as the mechanistic basis for evolution

Advanced Review
J.S. Torday
Published Online: May 25 2015
DOI:10.1002/wsbm.1305

Abstract Full article on Wiley Online Library:   HTML | PDF
Bringing computational models of bone regeneration to the clinic

Advanced Review
Aurélie Carlier, Liesbet Geris, Johan Lammens, Hans Van Oosterwyck
Published Online: Apr 21 2015
DOI:10.1002/wsbm.1299

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrating multi‐scale knowledge on cardiac development into a computational model of ventricular trabeculation

Focus Article
Bouke A. de Boer, Jean‐François Le Garrec, Vincent M. Christoffels, Sigolène M. Meilhac, Jan M. Ruijter
Published Online: Oct 06 2014
DOI:10.1002/wsbm.1285

Abstract Full article on Wiley Online Library:   HTML | PDF
Cell mechanics: principles, practices, and prospects

Overview
Emad Moeendarbary, Andrew R. Harris
Published Online: Jul 28 2014
DOI:10.1002/wsbm.1275

Abstract Full article on Wiley Online Library:   HTML | PDF
Tactile sensory system: encoding from the periphery to the cortex

Focus Article
Lynette A. Jones, Allan M. Smith
Published Online: Mar 19 2014
DOI:10.1002/wsbm.1267

Abstract Full article on Wiley Online Library:   HTML | PDF
Signaling networks in palate development

Focus Article
Jamie Lane, Vesa Kaartinen
Published Online: Mar 18 2014
DOI:10.1002/wsbm.1265

Abstract Full article on Wiley Online Library:   HTML | PDF
Glass‐like dynamics in the cell and in cellular collectives

Advanced Review
Monirosadat Sadati, Amir Nourhani, Jeffrey J. Fredberg, Nader Taheri Qazvini
Published Online: Jan 15 2014
DOI:10.1002/wsbm.1258

Abstract Full article on Wiley Online Library:   HTML | PDF
Advances in modeling ventricular arrhythmias: from mechanisms to the clinic

Focus Article
Patrick M. Boyle, Natalia A. Trayanova
Published Online: Dec 06 2013
DOI:10.1002/wsbm.1256

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative approaches for modeling regulation and function of the respiratory system

Overview
Alona Ben‐Tal, Merryn H. Tawhai
Published Online: Sep 09 2013
DOI:10.1002/wsbm.1244

Abstract Full article on Wiley Online Library:   HTML | PDF
Endothelial cell motility, coordination and pattern formation during vasculogenesis

Advanced Review
Andras Czirok
Published Online: Jul 15 2013
DOI:10.1002/wsbm.1233

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of kidney transport

Advanced Review
Anita T. Layton
Published Online: Jul 12 2013
DOI:10.1002/wsbm.1232

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale image‐based modeling and simulation of gas flow and particle transport in the human lungs

Focus Article
Ching‐Long Lin, Merryn H. Tawhai, Eric A. Hoffman
Published Online: Jul 10 2013
DOI:10.1002/wsbm.1234

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational and experimental characterization of skin mechanics: identifying current challenges and future directions

Advanced Review
Jessica W.Y. Jor, Matthew D. Parker, Andrew J. Taberner, Martyn P. Nash, Poul M.F. Nielsen
Published Online: Jun 11 2013
DOI:10.1002/wsbm.1228

Abstract Full article on Wiley Online Library:   HTML | PDF
A conceptual framework for computational models of Achilles tendon homeostasis

Advanced Review
David W. Smith, Jonas Rubenson, David Lloyd, Minghao Zheng, Justin Fernandez, Thor Besier, Jiake Xu, Bruce S. Gardiner
Published Online: Jun 11 2013
DOI:10.1002/wsbm.1229

Abstract Full article on Wiley Online Library:   HTML | PDF
How changes in fibril‐level organization correlate with the macrolevel behavior of articular cartilage

Focus Article
Mieke Nickien, Ashvin Thambyah, Neil Broom
Published Online: Apr 01 2013
DOI:10.1002/wsbm.1220

Abstract Full article on Wiley Online Library:   HTML | PDF
Toward the virtual stomach: progress in multiscale modeling of gastric electrophysiology and motility

Focus Article
Peng Du, Gregory O'Grady, Jerry Gao, Shameer Sathar, Leo K. Cheng
Published Online: Mar 05 2013
DOI:10.1002/wsbm.1218

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of lung development and regeneration: current knowledge and recommendations for future research

Opinion
Namasivayam Ambalavanan, James S. Hagood
Published Online: Jan 04 2013
DOI:10.1002/wsbm.1205

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of skeletal muscle: fiber type as an organizing principle

Advanced Review
Sarah M. Greising, Heather M. Gransee, Carlos B. Mantilla, Gary C. Sieck
Published Online: Jul 18 2012
DOI:10.1002/wsbm.1184

Abstract Full article on Wiley Online Library:   HTML | PDF
Decoding the functions of post‐transcriptional regulators in the determination of inflammatory states: focus on macrophage activation

Focus Article
Panagiota Kafasla, Ioannis Karakasiliotis, Dimitris L. Kontoyiannis
Published Online: Jul 03 2012
DOI:10.1002/wsbm.1179

Abstract Full article on Wiley Online Library:   HTML | PDF
Hydrogels for in vivo‐like three‐dimensional cellular studies

Advanced Review
Hyun‐Joon Kong, Ross DeVolder
Published Online: May 21 2012
DOI:10.1002/wsbm.1174

Abstract Full article on Wiley Online Library:   HTML | PDF
Sex and the circuitry: progress toward a systems‐level understanding of vertebrate sex determination

Focus Article
Blanche Capel, Steven C. Munger
Published Online: May 17 2012
DOI:10.1002/wsbm.1172

Abstract Full article on Wiley Online Library:   HTML | PDF
The virtual liver: a multidisciplinary, multilevel challenge for systems biology

Overview
Hermann‐Georg Holzhütter, Dirk Drasdo, Tobias Preusser, Jörg Lippert, Adriano M. Henney
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1158

Abstract Full article on Wiley Online Library:   HTML | PDF
Hybrid models of tumor growth

Focus Article
Alexander R. A. Anderson, Katarzyna A. Rejniak
Published Online: Dec 16 2010
DOI:10.1002/wsbm.102

Abstract Full article on Wiley Online Library:   HTML | PDF
In silico models of bone remodeling from macro to nano—from organ to cell

Focus Article
Duncan Webster, Ralph Müller
Published Online: Aug 25 2010
DOI:10.1002/wsbm.115

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling of blood flow in arterial trees

Focus Article
Tomer Anor, Leopold Grinberg, Hyoungsu Baek, Joseph R. Madsen, Mahesh V. Jayaraman, George E. Karniadakis
Published Online: Aug 04 2010
DOI:10.1002/wsbm.90

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling breast biomechanics for multi‐modal image analysis—successes and challenges

Advanced Review
Vijay Rajagopal, Poul M. F. Nielsen, Martyn P. Nash
Published Online: Apr 09 2010
DOI:10.1002/wsbm.58

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of pro‐angiogenic therapies targeting the VEGF system

Focus Article
Feilim Mac Gabhann, Amina A. Qutub, Brian H. Annex, Aleksander S. Popel
Published Online: Apr 07 2010
DOI:10.1002/wsbm.92

Abstract Full article on Wiley Online Library:   HTML | PDF
T cell responses in lymph nodes

Focus Article
Gib Bogle, P. Rod Dunbar
Published Online: Jan 15 2010
DOI:10.1002/wsbm.47

Abstract Full article on Wiley Online Library:   HTML | PDF
Kidney modeling and systems physiology

Advanced Review
S. Randall Thomas
Published Online: Sep 22 2009
DOI:10.1002/wsbm.14

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational modeling of epithelial tissues

Advanced Review
Rod Smallwood
Published Online: Sep 22 2009
DOI:10.1002/wsbm.18

Abstract Full article on Wiley Online Library:   HTML | PDF
The lung physiome: merging imaging‐based measures with predictive computational models

Advanced Review
Merryn H. Tawhai, Eric A. Hoffman, Ching‐Long Lin
Published Online: May 05 2009
DOI:10.1002/wsbm.17

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale systems integration in the eye

Advanced Review
Marc D. Jacobs
Published Online: May 05 2009
DOI:10.1002/wsbm.29

Abstract Full article on Wiley Online Library:   HTML | PDF
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