Examples of understanding safety data using graphical methods
Advanced Review
Published Online: Dec 26 2012
DOI: 10.1002/wics.1243
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Abstract Cardiac and hepatic safety are important considerations in drug development. This article focuses on the examination of laboratory and electrocardiogram data using graphical approaches that enable a better understanding of the data. Useful general principles to keep in mind when developing graphics are followed by sections on cardiovascular and hepatic safety. WIREs Comput Stat 2013, 5:78–95. doi: 10.1002/wics.1243 This article is categorized under: Applications of Computational Statistics > Clinical Trials Statistical Learning and Exploratory Methods of the Data Sciences > Exploratory Data Analysis Data: Types and Structure > Data Preparation and Processing Statistical and Graphical Methods of Data Analysis > Statistical Graphics and Visualization
Trellis plot of liver test safety panel over time, baseline versus on‐study.
1 × 4 scatter plot of liver function test shift from baseline to maximum.
2 × 2 scatter plot of liver function test shift from baseline to maximum.
Maximum total bilirubin versus maximum alanine aminotransferase (ALT).
