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Sequential diagnostic trial designs

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Abstract Group sequential design (GSD) as an alternative of the fixed sample design addresses both cost and ethical concerns in diagnostic trials. In this article, we review GSD methods for comparing the diagnostic accuracy of markers in diagnostic trials. We also review sample size calculation methods in such trials. WIREs Comp Stat 2011 3 79–83 DOI: 10.1002/wics.136 This article is categorized under: Applications of Computational Statistics > Clinical Trials

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