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WIREs Nanomed Nanobiotechnol
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Recent advances in stealth coating of nanoparticle drug delivery systems

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Abstract Modifying surfaces of nanoparticles (NPs) with polyethylene glycol (PEG), the so‐called PEGylation, is the most commonly used method for reducing premature clearance of NPs from the circulation. However, several reports point out that PEGylation may negatively influence the performance of NPs as a drug carrier. Alternative surface modification strategies, including substitute polymers, conditional removal of PEG, and biomimetic surface modification, may provide solutions for the limitations of PEG. WIREs Nanomed Nanobiotechnol 2012, 4:219–233. doi: 10.1002/wnan.1157 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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(a) Polyethylene glycol (PEG) structure; (b) model of PEGylated nanoparticles (NPs).

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DePEGylation of NPs by cellular cues.

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Poly(hydroxymethylethylene hydroxymethylformal).

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Structures of chitosan, heparin, and dextran.

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Structure of hyperbranched polyglycerol.127

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Structures of poly(sulfobetaine) and poly(carboxybetaine).

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Structures of poly(2‐ethyl‐2‐oxazoline), poly(hydroxyethyl‐l‐asparagine) (PHEA), and N‐(2‐hydroxypropyl)methacrylamide (HPMA).

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Schematic description of NP‐based drug delivery to tumors. Arrows indicate steps negatively influenced by PEG layer on NP surface.

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Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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