This Title All WIREs
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 7.689

Why I believe nanoparticles are crucial as a carrier for targeted drug delivery

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Abstract Nanoparticles are the only materials small enough to target cells in the body, and therefore are crucial to targeted drug delivery. Issues with the synthesis, consistency, and bioactivity of these molecules are still being addressed, but base on current proof of concept studies there is a reason to believe that the ‘holy grail’ of targeted drug delivery might someday be achieved using nanoparticle‐based systems. WIREs Nanomed Nanobiotechnol 2013. doi: 10.1002/wnan.1226 This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > In Vitro Nanoparticle-Based Sensing Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

This WIREs title offers downloadable PowerPoint presentations of figures for non-profit, educational use, provided the content is not modified and full credit is given to the author and publication.

Download a PowerPoint presentation of all images

The ability of targeted drug therapy to reduce drug toxicity. Mice on left dosed with free methotrexate lose weight, hair and appear sick due to systemic toxicity. Mice on right dosed with folate‐targeted dendrimer methotrexate exhibit no adverse effects from the chemotherapy but have drug‐induced necrosis of the tumor on the mice.
[ Normal View | Magnified View ]
Coupling both drug (methotrexate) and targeting ligand (folate) to a dendrimer using a triazine linker and click chemistry offers more efficient coupling and fixed ratios of drug and targeting ligand.
[ Normal View | Magnified View ]
The biodistribution of targeted versus nontargeted tritium‐labeled dendrimers. Note that the uptake in the folate receptor positive tumor was 10‐fold higher in the targeted dendrimers and persisted over time.
[ Normal View | Magnified View ]
A multifunctional dendrimer containing a targeting molecule (folate), a drug (methotrexate), and a dye molecule (fluorescein), the latter used to follow the therapeutics in vivo distribution.
[ Normal View | Magnified View ]
A dendron where a single dye molecule is coupled to multiple targeting ligands. This can also be used to target drugs as well as dyes, and allows for every carrier to have one drug and multiple ligands for high avidity interactions and efficient targeting.
[ Normal View | Magnified View ]
The challenges of drug delivery in reaching targeted cells.
[ Normal View | Magnified View ]

Browse by Topic

Diagnostic Tools > In Vitro Nanoparticle-Based Sensing
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Therapeutic Approaches and Drug Discovery > Emerging Technologies

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts