Stewart, B, Wild, CP. World Cancer Report 2014. Lyon: International Agency for Research on Cancer ‐ World Health Organization; 2014, 630.
Sadikovic, B, Al‐Romaih, K, Squire, JA, Zielenska, M. Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics 2008, 9:394–408.
Cordoncardo, C, Wartinger, D, Petrylak, D, Dalbagni, G, Fair, WR, Fuks, Z, Reuter, VE. Altered expression of the retinoblastoma gene‐product ‐ prognostic indicator in bladder‐cancer. J Natl Cancer Inst 1992, 84:1251–1256.
Cvetkovic, D, Pisarcik, D, Lee, C, Hamilton, TC, Abdollahi, A. Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer. Gynecol Oncol 2004, 95:449–455.
Luo, JH, Yu, YP, Cieply, K, Lin, F, Deflavia, P, Dhir, R, Finkelstein, S, Michalopoulos, G, Becich, M. Gene expression analysis of prostate cancers. Mol Carcinog 2002, 33:25–35.
David, CJ, Manley, JL. Alternative pre‐mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev 2010, 24:2343–2364.
Schwarzenbach, H, Hoon, DSB, Pantel, K. Cell‐free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011, 11:426–437.
Sana, J, Faltejskova, P, Svoboda, M, Slaby, O. Novel classes of non‐coding RNAs and cancer. J Transl Med 2012, 10:103.
Absalon, S, Kochanek, DM, Raghavan, V, Krichevsky, AM. MiR‐26b, upregulated in Alzheimer`s disease, activates cell cycle entry, tau‐phosphorylation, and apoptosis in postmitotic neurons. J Neurosci 2013, 33:14645–14659.
Fichtlscherer, S, Zeiher, AM, Dimmeler, S. Circulating microRNAs: biomarkers or mediators of cardiovascular diseases? Arterioscler Thromb Vasc Biol 2011, 31:2383–2390.
Foley, NH, O`Neill, LA. miR‐107: a toll‐like receptor‐regulated miRNA dysregulated in obesity and type II diabetes. J Leukoc Biol 2012, 92:521–527.
Li, Y, Kowdley, KV. MicroRNAs in common human diseases. Genomics Proteomics Bioinformatics 2012, 10:246–253.
Lujambio, A, Lowe, SW. The microcosmos of cancer. Nature 2012, 482:347–355.
Mitchell, PS, Parkin, RK, Kroh, EM, Fritz, BR, Wyman, SK, Pogosova‐Agadjanyan, EL, Peterson, A, Noteboom, J, O`Briant, KC, Allen, A, et al. Circulating microRNAs as stable blood‐based markers for cancer detection. Proc Natl Acad Sci 2008, 105:10513–10518.
Lu, J, Getz, G, Miska, EA, Alvarez‐Saavedra, E, Lamb, J, Peck, D, Sweet‐Cordero, A, Ebert, BL, Mak, RH, Ferrando, AA, et al. MicroRNA expression profiles classify human cancers. Nature 2005, 435:834–838.
Wu, JY. RNA and Cancer. New York: Springer; 2013, 245.
Allegra, A, Penna, G, Alonci, A, Rizzo, V, Russo, S, Musolino, C. Nanoparticles in oncology: the new theragnostic molecules. Anticancer Agents Med Chem 2011, 11:669–686.
National Cancer Institute. 2004. Questions and Answers: Cancer Nanotechnology. Available at: http://www.cancer.gov/newscenter/qa/2004/nanotechqa. (Accessed July 28, 2013)
Choi, YE, Kwak, JW, Park, JW. Nanotechnology for early cancer detection. Sensors (Basel) 2010, 10:428–455.
Ahmed, N, Fessi, H, Elaissari, A. Theranostic applications of nanoparticles in cancer. Drug Discov Today 2012, 17:928–934.
Perfezou, M, Turner, A, Merkoci, A. Cancer detection using nanoparticle‐based sensors. Chem Soc Rev 2012, 41:2606–2622.
Sailor, MJ, Park, JH. Hybrid nanoparticles for detection and treatment of cancer. Adv Mater 2012, 24:3779–3802.
Yigit, MV, Moore, A, Medarova, Z. Magnetic nanoparticles for cancer diagnosis and therapy. Pharm Res 2012, 29:1180–1188.
Baptista, PV. RNA quantification with gold nanoprobes for cancer diagnostics. Clin Lab Med 2012, 32:1–13.
Zhao, X, Tapec‐Dytioco, R, Wang, K, Tan, W. Collection of trace amounts of DNA/mRNA molecules using genomagnetic nanocapturers. Anal Chem 2003, 75:3476–3483.
Conde, J, de la Fuente, J, Baptista, P. RNA quantification using gold nanoprobes ‐ application to cancer diagnostics. J Nanobiotechnol 2010, 8:5.
Baptista, PV, Doria, G, Conde, J. Alloy metal nanoparticles for multicolor cancer diagnostics. Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI, San Francisco, CA, 2011, 7909.
Seferos, DS, Giljohann, DA, Hill, HD, Prigodich, AE, Mirkin, CA. Nano‐flares: probes for transfection and mRNA detection in living cells. J Am Chem Soc 2007, 129:15477–15479.
Prigodich, AE, Randeria, PS, Briley, WE, Kim, NJ, Daniel, WL, Giljohann, DA, Mirkin, CA. Multiplexed nanoflares: mRNA detection in live cells. Anal Chem 2062–2066, 2012:84.
Prigodich, AE, Seferos, DS, Massich, MD, Giljohann, DA, Lane, BC, Mirkin, CA. Nano‐flares for mRNA Regulation and Detection. ACS Nano 2009, 3:2147–2152.
Li, N, Chang, C, Pan, W, Tang, B. A multicolor nanoprobe for detection and imaging of tumor‐related mRNAs in living cells. Angew Chem Int Ed Engl 2012, 51:7426–7430.
Harry, SR, Hicks, DJ, Amiri, KI, Wright, DW. Hairpin DNA coated gold nanoparticles as intracellular mRNA probes for the detection of tyrosinase gene expression in melanoma cells. Chem Commun 2010, 46:5557–5559.
Qiao, G, Gao, Y, Li, N, Yu, Z, Zhuo, L, Tang, B. Simultaneous detection of intracellular tumor mRNA with bi‐color imaging based on a gold nanoparticle/molecular beacon. Chemistry 2011, 17:11210–11215.
Rosa, J, Conde, J, de la Fuente, JM, Lima, JC, Baptista, PV. Gold‐nanobeacons for real‐time monitoring of RNA synthesis. Biosens Bioelectron 2012, 36:161–167.
Wu, MS, Qian, GS, Xu, JJ, Chen, HY. Sensitive electrochemiluminescence detection of c‐Myc mRNA in breast cancer cells on a wireless bipolar electrode. Anal Chem 2012, 84:5407–5414.
Chen, Y, Chen, G, Feng, S, Pan, J, Zheng, X, Su, Y, Chen, Y, Huang, Z, Lin, X, Lan, F, et al. Label‐free serum ribonucleic acid analysis for colorectal cancer detection by surface‐enhanced Raman spectroscopy and multivariate analysis. J Biomed Opt 2012, 17:067003.
Chen, Y, Chen, G, Zheng, X, He, C, Feng, S, Chen, Y, Lin, X, Chen, R, Zeng, H. Discrimination of gastric cancer from normal by serum RNA based on surface‐enhanced Raman spectroscopy (SERS) and multivariate analysis. Med Phys 2012, 39:5664–5668.
Cao, YWC, Jin, RC, Mirkin, CA. Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. Science 2002, 297:1536–1540.
Baptista, P, Doria, G, Henriques, D, Pereira, E, Franco, R. Colorimetric detection of eukaryotic gene expression with DNA‐derivatized gold nanoparticles. J Biotechnol 2005, 119:111–117.
Maxwell, DJ, Taylor, JR, Nie, S. Self‐assembled nanoparticle probes for recognition and detection of biomolecules. J Am Chem Soc 2002, 124:9606–9612.
Cissell, KA, Shrestha, S, Deo, SK. MicroRNA detection: challenges for the analytical chemist. Anal Chem 2007, 79:4754–4761.
Fan, Y, Chen, X, Trigg, AD, Tung, CH, Kong, J, Gao, Z. Detection of MicroRNAs using target‐guided formation of conducting polymer nanowires in nanogaps. J Am Chem Soc 2007, 129:5437–5443.
Li, J, Schachermeyer, S, Wang, Y, Yin, Y, Zhong, W. Detection of microRNA by fluorescence amplification based on cation‐exchange in nanocrystals. Anal Chem 2009, 81:9723–9729.
Roy, S, Soh, JH, Gao, Z. A microfluidic‐assisted microarray for ultrasensitive detection of miRNA under an optical microscope. Lab Chip 1886–1894, 2011:11.
Alhasan, AH, Kim, DY, Daniel, WL, Watson, E, Meeks, JJ, Thaxton, CS, Mirkin, CA. Scanometric MicroRNA array profiling of prostate cancer markers using spherical nucleic acid–gold nanoparticle conjugates. Anal Chem 2012, 84:4153–4160.
Xia, N, Zhang, L, Wang, G, Feng, Q, Liu, L. Label‐free and sensitive strategy for microRNAs detection based on the formation of boronate ester bonds and the dual‐amplification of gold nanoparticles. Biosens Bioelectron 2013, 47:461–466.
Kim, E, Yang, J, Park, J, Kim, S, Kim, NH, Yook, JI, Suh, JS, Haam, S, Huh, YM. Consecutive targetable smart nanoprobe for molecular recognition of cytoplasmic microRNA in metastatic breast cancer. ACS Nano 2012, 6:8525–8535.
Kim, JK, Choi, K‐J, Lee, M, M‐h, J, Kim, S. Molecular imaging of a cancer‐targeting theragnostics probe using a nucleolin aptamer‐ and microRNA‐221 molecular beacon‐conjugated nanoparticle. Biomaterials 2012, 33:207–217.
Conde, J, Rosa, J, de la Fuente, JM, Baptista, PV. Gold‐nanobeacons for simultaneous gene specific silencing and intracellular tracking of the silencing events. Biomaterials 2013, 34:2516–2523.
Liang, R‐Q, Li, W, Li, Y, Tan, C‐y, Li, J‐X, Jin, Y‐X, Ruan, K‐C. An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe. Nucleic Acids Res 2005, 33:e17.
Huang, JX, Mehrens, D, Wiese, R, Lee, S, Tam, SW, Daniel, S, Gilmore, J, Shi, M, Lashkari, D. High‐throughput genomic and proteomic analysis using microarray technology. Clin Chem 1912–1916, 2001:47.
Egholm, M, Buchardt, O, Christensen, L, Behrens, C, Freier, SM, Driver, DA, Berg, RH, Kim, SK, Norden, B, Nielsen, PE. PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen‐bonding rules. Nature 1993, 365:566–568.
Peirson, S, Butler, J. RNA extraction from mammalian tissues. In: Rosato, E, ed. Circadian Rhythms, vol. 362. Humana Press; 2007, 315–327.
Shabarova, ZA, Bogdanov, AA. Primary structure of nucleic acids. In: Advanced Organic Chemistry of Nucleic Acids. Weinheim, Germany: VCH Verlagsgesellschaft mbH; 1994, 187.
Rivas, A, Burzio, V, Landerer, E, Borgna, V, Gatica, S, Avila, R, Lopez, C, Villota, C, de la Fuente, R, Echenique, J, et al. Determination of the differential expression of mitochondrial long non‐coding RNAs as a noninvasive diagnosis of bladder cancer. BMC Urol 2012, 12:37.
Baraniskin, A, Noepel‐Duennebacke, S, Ahrens, M, Jensen, SG, Zoellner, H, Maghnouj, A, Wos, A, Mayerle, J, Munding, J, Kost, D, et al. Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma. Int J Cancer 2013, 132:E48–E57.
Elsaesser, A, Howard, CV. Toxicology of nanoparticles. Adv Drug Deliv Rev 2012, 64:129–137.
Klien, K, Godnic‐Cvar, J. Genotoxicity of metal nanoparticles: focus on in vivo studies. Arh Hig Rada Toksikol 2012, 63:133–145.
Conde, J, Larguinho, M, Cordeiro, A, Raposo, LR, Costa, PM, Santos, S, Diniz, MS, Fernandes, AR, Baptista, PV. Gold‐nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotoxicology 2013, 8:521–532.