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WIREs Nanomed Nanobiotechnol
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Nanotechnology for surgeons

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Abstract At first glance it might appear that nanomedicine is irrelevant to surgery as it is practiced today, as surgery is generally concerned with the manipulation of decidedly macroscopic devices. However, surgery as a discipline is obviously not limited to clinical procedures, but dovetails with parallel medical therapeutics. Consequently, methodologies that can enhance overall perioperative care are important. An alternative view is that nanomedicine is perhaps destined to put surgeons out of certain kinds of business—much as minimally invasive techniques including invasive radiology have progressively infringed on clinical areas that were once the purview of more conventional surgical approaches. As is often the case, the truth is somewhere in the middle. In any event nanotechnology certainly has the potential to affect the field. It is important to understand that potential and how it can be harnessed. WIREs Nanomed Nanobiotechnol 2011 3 223–228 DOI: 10.1002/wnan.128 This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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Basic nanomaterials. (a) Single crystalline silver nanoparticles for molecular sensing.1 (b) Self‐assembled DNA polyhedral nanoparticles that can potentially serve as drug delivery vehicles.2 (c) Ultrathin gold nanowires3 that might be used for electrical interconnects for nanoelectronic sensors and/or to enable electrical shortcuts among cells in tissue. (d) Peptide‐amphiphile nanofibers that mimic the extracellular matrix.4 (Reprinted with permission from Ref 1. Copyright 2007 Nature Publishing Group, Ref 2. Copyright 2008 Nature Publishing Group, Ref 3. Copyright 2008 American Chemical Society, Ref 4. Copyright 2007 American Association for the Advancement of Science)

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Nanobaroque. Core–shell nanoparticle (two phases, possibly containing different drugs, and that may respond to different stimuli) coated with PEG (blue) to prolong circulation half‐life, and functionalized with two targeting ligands (red and green) as well as ferromagnetic nanoparticles (yellow) to provide imaging and hyperthermia capability.

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Diagnostic Tools > Diagnostic Nanodevices
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery

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