This Title All WIREs
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 7.689

Learning from biology: synthetic lipoproteins for drug delivery

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical agents (chemotherapeutics, siRNAs, photosensitizers, and imaging contrast agents) into various cell types. These nanoparticles offer a number of advantages for drugs delivery over their native counterparts while retaining their natural characteristics and biological functions. Their ultra‐small size (<30 nm), high biocompatibility, favorable circulation half‐life, and natural ability to bind specific lipoprotein receptors, i.e., low‐density lipoprotein receptor (LDLR) and Scavenger receptor class B member 1 (SRB1) that are found in a number of pathological conditions (e.g., cancer, atherosclerosis), make them superior delivery strategies when compared with other nanoparticle systems. We review the various approaches that have been developed for the generation of synthetic lipoproteins and their respective applications in vitro and in vivo. More specifically, we summarize the approaches employed to address the limitation on use of reconstituted lipoproteins by means of natural or recombinant apolipoproteins, as well as apolipoprotein mimetic molecules. Finally, we provide an overview of the advantages and disadvantages of these approaches and discuss future perspectives for clinical translation of these nanoparticles. WIREs Nanomed Nanobiotechnol 2015, 7:298–314. doi: 10.1002/wnan.1308 This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Biology-Inspired Nanomaterials > Lipid-Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
The schematic (not drawn to scale) of a lipoprotein drug delivery vehicle. As depicted, it has the ability to carry both hydrophobic molecules through encapsulation in the core, and hydrophilic molecules through conjugation/insertion on its surface.
[ Normal View | Magnified View ]

Related Articles

Nanotechnology and Cancer

Browse by Topic

Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Biology-Inspired Nanomaterials > Lipid-Based Structures

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts