Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 7.689

Dendrimer‐entrapped metal colloids as imaging agents

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

This review reports the recent advances in dendrimer‐entrapped metal colloids as contrast agents for biomedical imaging applications. The versatile dendrimer scaffolds with 3‐dimensional spherical shape, highly branched internal cavity, tunable surface conjugation chemistry, and excellent biocompatibility and nonimmunogenicity afford their uses as templates to create multifunctional dendrimer‐entrapped metal colloids for mono‐ or multi‐ mode molecular imaging applications. In particular, multifunctional dendrimer‐entrapped gold nanoparticles with different surface modifications have been used for fluorescence imaging, targeted tumor computed tomography (CT) imaging, enhanced blood pool CT imaging, dual mode CT/MR imaging, and tumor theranostics (combined CT imaging and chemotherapy) will be introduced and discussed in detail. WIREs Nanomed Nanobiotechnol 2015, 7:678–690. doi: 10.1002/wnan.1331 This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Schematic illustration of the molecular structure of PAMAM dendrimers, which can be divided into three main components: the core, the internal cavity, and the shell (terminal functional groups).
[ Normal View | Magnified View ]
Representative transverse CT images (a) and CT values (b) of the U87MG tumor xenografts in nude mice before and after intravenous injection of Au‐TOS‐FA (1) and Au‐TOS (2) DENPs for 2 h and 24 h, respectively. The white star in (a) indicates the location of the tumor. (c) The growth of U87MG xenografted tumors after various treatments. (d) The body weight of U87MG tumor‐bearing mice after various treatments. The relative tumor volumes and body weight were normalized according to their initial weights (Mean ± SD, n = 6). (Reprinted with permission from Ref . Copyright 2014 Elsevier)
[ Normal View | Magnified View ]
Schematic illustration of the synthesis of Au‐TOS‐FA DENPs. (Reprinted with permission from Ref . Copyright 2014 Elsevier)
[ Normal View | Magnified View ]
The CT values (a) and T1 MR SNRs (b) of mice bearing transplanted KB tumors after intravenous injection of targeted Gd‐Au DENPs‐FA and nontargeted Gd‐Au DENPs for 0, 2, 6, and 24 h, respectively. (Reprinted with permission from Ref . Copyright 2013 Elsevier)
[ Normal View | Magnified View ]
Schematic illustration of the designed nanostructure (a) and the synthesis procedure (b) of the Gd‐Au DENPs. TEA and Ac2O represent triethylamine and acetic anhydride, respectively. (Reprinted with permission from Ref . Copyright 2013 Elsevier)
[ Normal View | Magnified View ]
Schematic illustration of the preparation of the [(Au0)n‐G5.NHAc‐mPEG20] DENPs (a). (b) and (c) The high‐resolution TEM image and selected area electron diffraction pattern of [(Au0)100‐G5.NHAc‐mPEG20] DENPs. (Reprinted with permission from Ref . Copyright 2012 Elsevier)
[ Normal View | Magnified View ]
Transection micro‐CT images (a) and CT values (b) of the xenograft SPC‐A1 tumor in nude mice before and after intraperitoneally injected with acetylated Au DENPs ([Au] = 0.2 M) for 1, 2, 4, and 6 h. (Reprinted with permission from Ref . Copyright 2011 Elsevier)
[ Normal View | Magnified View ]

Browse by Topic

Diagnostic Tools > Diagnostic Nanodevices
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts