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WIREs Nanomed Nanobiotechnol
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Combinatorial nanomedicines for colon cancer therapy

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Colon cancer is one of the major causes of cancer deaths worldwide. Even after surgical resection and aggressive chemotherapy, 50% of colorectal carcinoma patients develop recurrent disease. Thus, the rationale of developing new therapeutic approaches to improve the current chemotherapeutic regimen would be highly recommended. There are reports on the effectiveness of combination chemotherapy in colon cancer and it has been practiced in clinics for long time. These approaches are associated with toxic side effects. Later, the drug delivery research had shown the potential of nanoencapsulation techniques and active targeting as an effective method to improve the effectiveness of chemotherapy with less toxicity. This current focus article provides a brief analysis of the ongoing research in the colon cancer area using the combinatorial nanomedicines and its outcome. WIREs Nanomed Nanobiotechnol 2015, 8:151–159. doi: 10.1002/wnan.1353 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
(a) Depict the staging of colon cancer, and (b) depicts the presence of colon polyps and cancerous areas in the different regions of colon. (Source: http://www.medicinenet.com/colon_cancer/article.htm)
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The mechanistic pathway through which CRC sensitizes HT‐29 to 5‐FU and the combinatorial effect of dual drug‐loaded nanoparticles. (Reprinted with permission from Ref . Copyright 2015 Elsevier)
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Z stacked images of HT‐29 cells treated with Rhod 123‐CRC‐N, O‐CMC NPs for 6 h using Confocal Laser Scanning Microscopy (CLSM), where the merged views of fluorescence from the tetramethylrhodamine (TRITC)‐stained actin filaments/Rhod 123‐CRC‐N, O‐CMC NPs were measured. Nine confocal sections from the basal to the apical cell side (Z1–Z9 planes) are depicted as (a), (b), (c), (d), (e), (f), (g), (h), and (i), respectively (scale bar represents 50 µm) (Done in triplicates; n = 3, and each experiment was repeated thrice). (Unpublished data, A. Anitha)
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Scheme representing the effect of combinatorial treatment of CRC‐loaded thiolated chitosan nanoparticles (CRC‐TCS NPs) and 5‐FU‐loaded thiolated chitosan nanoparticles (5‐FU‐TCS NPs) in colon cancer (HT‐29) cells. (Reprinted with permission from Ref . Copyright 2015 Elsevier)
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The flow chart depicting the advantages of combinatorial nanomedicines in colon cancer treatment.
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