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WIREs Nanomed Nanobiotechnol
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Engineering of radiolabeled iron oxide nanoparticles for dual‐modality imaging

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Over the last decade, radiolabeled iron oxide nanoparticles have been developed as promising contrast agents for dual‐modality positron emission tomography/magnetic resonance imaging (PET/MRI) or single‐photon emission computed tomography/magnetic resonance imaging (SPECT/MRI). The combination of PET (or SPECT) with MRI can offer synergistic advantages for noninvasive, sensitive, high‐resolution, and quantitative imaging, which is suitable for early detection of various diseases such as cancer. Here, we summarize the recent advances on radiolabeled iron oxide nanoparticles for dual‐modality imaging, through the use of a variety of PET (and SPECT) isotopes by using both chelator‐based and chelator‐free radiolabeling techniques. WIREs Nanomed Nanobiotechnol 2016, 8:619–630. doi: 10.1002/wnan.1386 This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
(a) An illustration of SPECT/MRI multimodality imaging using 99mTc‐PEG‐BP‐USPIO. (b) In vivo T1‐weighted MR imaging study on vessels (upper) and heart (down) of mice after injected with PEG(5)‐BP‐USPIO (Labels: H = heart, S = spleen, K = kidney, A = aorta, M = myocardium, LV = left ventricle. (Reprinted with permission from Ref . Copyright 2013 American Chemical Society)
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(a) A schematic illustration of using 64Cu‐MoS2‐IONPs for multimodality image‐guided photothermal therapy. (b) A TEM image of PEGylated MoS2‐IONPs. (c) PET imaging of 4T1 tumor‐bearing mice after the injection of 64Cu‐MoS2‐IONPs. (d) MR imaging of 4T1 tumor‐bearing mice after the injection of 64Cu‐MoS2‐IONPs. (Reprinted with permission from Ref . Copyright 2015 American Chemical Society)
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(a) A schematic illustration of chelator‐free synthesis of *As (or 69Ge)‐[email protected]‐PEG. (b) A TEM image of oleic acid capped IONPs. (c) A TEM image of PAA modified IONPs. (d) In vivo PET imaging of lymph nodes after the injection of *As‐[email protected]‐PEG. (d) In vivo MR imaging of lymph nodes after the injection of *As‐[email protected]‐PEG. (Reprinted with permission from Ref . Copyright 2013 WILEY‐VCH Verlag GmbH & Co. KGaA)
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(a) A schematic illustration of Au‐IONP‐Affibody. (b) A TEM image of Au‐IONP. (c) A high‐angle annular dark field image of Au‐IONP. The Au nanoparticles were shown as the bright dots. (d) In vivo PET imaging of A431 tumor‐bearing mice acquired 24 h after the injection of 64Cu‐NOTA‐Au‐IONP‐Affibody. From left to right: targeted group and blocking group. (e) In vivo MR imaging of A431 tumor‐bearing mice acquired 24 h after the injection of 64Cu‐NOTA‐Au‐IONP‐Affibody. Tumors were marked by yellow arrow‐heads. (Reprinted with permission from Ref . Copyright 2013 Elsevier Ltd.)
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(a) A schematic illustration of the 64Cu‐NOTA‐IONP(DOX)‐cRGD nanoconjugates for combined tumor‐targeted drug delivery and PET/MRI imaging. (b) A TEM image of IONP(DOX)‐cRGD. (c) In vivo PET images of U87MG tumor‐bearing mice 24 h after injection of different nanoconjugates. From left to right: targeted group (64Cu‐NOTA‐IONP‐cRGD), nontargeted group (64Cu‐NOTA‐IONP), and blocking group. Tumors were marked by yellow arrow‐heads. (Reprinted with permission from Ref . Copyright 2011 Elsevier Ltd.)
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Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

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