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WIREs Nanomed Nanobiotechnol
Impact Factor: 7.689

Peptide nanostructures in biomedical technology

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Nanostructures of peptides have been investigated for biomedical applications due to their unique mechanical and electrical properties in addition to their excellent biocompatibility. Peptides may form fibrils, spheres and tubes in nanoscale depending on the formation conditions. These peptide nanostructures can be used in electrical, medical, dental, and environmental applications. Applications of these nanostructures include, but are not limited to, electronic devices, biosensing, medical imaging and diagnosis, drug delivery, tissue engineering and stem cell research. This review offers a discussion of basic synthesis methods, properties and application of these nanomaterials. The review concludes with recommendations and future directions for peptide nanostructures. WIREs Nanomed Nanobiotechnol 2016, 8:730–743. doi: 10.1002/wnan.1393 This article is categorized under: Diagnostic Tools > Biosensing Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Peptide-Based Structures
Mechanism of self‐assembly of heptane bolaamphiphile peptide. (Reprinted with permission from Ref . Copyright 2000 American Chemical Society)
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Formation of peptide nanotubes from stacking of cyclic peptide monomers. (Reprinted with permission from Ref . Copyright 1996 American Chemical Society)
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Mechanism of formation of peptide nanospheres by polymerization of l‐phenylalanine N‐carboxyanhydride. (Reprinted with permission from Ref . Copyright 2006 American Chemical Society)
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(a) Molecular model of hundreds of self‐assembling peptides form a well‐ordered nanofiber with a defined diameter. (b) Transmission electron microscopy (TEM) image of nanofibers that form hydrogel in a scaffold. (Reprinted with permission from Ref . Copyright 2005 Elsevier)
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Formation of nanofibrils from peptide monomer. (Reprinted with permission from Ref . Copyright 2013 Elsevier)
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(a) Di‐l‐phenylalanine (dipeptide, phe‐phe) and (b) RGD (tripeptide, Arg‐Gly‐Asp).
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Typical peptide bond in an amide molecule.
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Diagnostic Tools > Biosensing
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Biology-Inspired Nanomaterials > Peptide-Based Structures

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