Peptide nanostructures in biomedical technology

Advanced Review

Hamid Feyzizarnagh, Do‐Young Yoon, Mark Goltz, Dong‐Shik Kim

Published Online: Feb 05 2016

DOI: 10.1002/wnan.1393

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Nanostructures of peptides have been investigated for biomedical applications due to their unique mechanical and electrical properties in addition to their excellent biocompatibility. Peptides may form fibrils, spheres and tubes in nanoscale depending on the formation conditions. These peptide nanostructures can be used in electrical, medical, dental, and environmental applications. Applications of these nanostructures include, but are not limited to, electronic devices, biosensing, medical imaging and diagnosis, drug delivery, tissue engineering and stem cell research. This review offers a discussion of basic synthesis methods, properties and application of these nanomaterials. The review concludes with recommendations and future directions for peptide nanostructures. WIREs Nanomed Nanobiotechnol 2016, 8:730–743. doi: 10.1002/wnan.1393 This article is categorized under: Diagnostic Tools > Biosensing Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Peptide-Based Structures

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(a) Molecular model of hundreds of self‐assembling peptides form a well‐ordered nanofiber with a defined diameter. (b) Transmission electron microscopy (TEM) image of nanofibers that form hydrogel in a scaffold. (Reprinted with permission from Ref . Copyright 2005 Elsevier)

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(a) Di‐l‐phenylalanine (dipeptide, phe‐phe) and (b) RGD (tripeptide, Arg‐Gly‐Asp).

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Typical peptide bond in an amide molecule.

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