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WIREs Nanomed Nanobiotechnol
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Progress in extracellular vesicle biology and their application in cancer medicine

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Abstract Under the broader category of extracellular vesicles (EVs), exosomes are now well recognized for their contribution and potential for biomedical research. During the last ten years, numerous technologies for purification and characterization of EVs have been developed. This enhanced knowledge has resulted in the development of novel applications of EVs. This review is an attempt to capture the exponential growth observed in EV science in the last decade and discuss the future potential to improve our understanding of EVs, develop technologies to overcome current limitations, and advance their utility for human benefit, especially in cancer medicine. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
The evolution of nomenclature of extracellular vesicles (EVs) over last the few decades. With the discovery of vesicles in the 1960s, they were named based on the cell of origin. In 1980s, EVs were named “Exosomes,” Micro‐vesicles, and Apoptotic bodies, depending on the mechanism of biogenesis. Recently, a more streamlined nomenclature system was developed which subdivided EVs based on their size and origin. sEV, small extracellular vesicles; mEV, medium extracellular vesicles; L‐EV, large extracellular vesicles
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The biogenesis and biological role of various types of extracellular vesicles in cell‐to‐cell communication
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The development of extracellular vesicle since their discovery. The line bars show rapid discoveries from a number of studies conducted in the last decade
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A dramatic surge in A, exosome and B, extracellular vesicle (EV)‐based studies was observed in the last decade compared with the years following the discovery of EVs. This surge is another indicator of the significance and recognition of EVs by the scientific community in the last ten years
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Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Therapeutic Approaches and Drug Discovery > Emerging Technologies

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