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WIREs Nanomed Nanobiotechnol
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Recent advances on synthesis and biomaterials applications of hyperbranched polymers

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Abstract Hyperbranched polymers represent an intriguing class of shape‐persistent soft nanomaterials that could be easily produced in one‐pot reaction to obtain highly branched arborescent structures. Although traditional synthesis of hyperbranched polymers suffers from the poorly defined structures and broad molecular weight distribution, recent progress on synthesis methods allows the production of structurally defined polymers in tunable molecular weights, composition and degree of branching. This review summarizes the recent advance on synthesis of hyperbranched polymers and their applications as biomaterials in tissue engineering scaffolds, diagnostic probe carriers and drug delivery fields. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Hyperbranched polymer architecture
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Construction of unimolecular nanocontainer for delivery of a two‐enzyme inhibitor. (Reprinted from Misra et al. (2015). Copyright 2015 Royal Society of Chemistry)
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Water‐soluble iron nanoparticles grafted with hyperbranched polymer, and extended with PEG, carrying folic acid for tumor targeted MRI imaging. (Reprinted from Mashhadi Malekzadeh et al. (2017). Copyright 2017 Elsevier)
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Microemulsion‐templated nanocontainer for siRNA delivery (Reprinted from Zhao et al. (2017). Copyright 2017 American Chemical Society)
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Use of RAFT copolymerization to synthesis branched polymer containing a drug payload, targeting ligand and fluorescence imaging probe (Reprinted from Pearce et al. (2014). Copyright 2014 Royal Society of Chemistry)
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Examples of hyperbranched polymer designs for drug delivery applications
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Delivery of miRNA in polyplexes formed with hyperbranched polymer, released from cell‐free scaffold to achieve regenerative therapy (Reprinted from Zhang, Li, Chen, Chen, and Ma (2016). Free Copyright under the terms of Creative Commons)
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Cartoon illustration of the injectable hydrogels using step‐growth polymerization derived hyperbranched polymer possessing cysteine‐induced degradability
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Self‐immolative polymers for targeted drug delivery with tunable trigger conditions (Reprinted from Liu et al. (2015). Copyright 2015 American Chemical Society)
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(a) Self‐assembly of branched polymers into lamellar phase for formation of vesicles and nanoparticles. (b) Self‐assembly of Janus particles into vesicles by host–guest photo‐switchable interactions (Reprinted from Liu et al. (2013). Copyright 2013 American Chemical Society)
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Recent methods for access to structurally controlled hyperbranched polymers. (a) Polymerization in confined space (Reprinted from Graff, Wang, and Gao (2015). Copyright 2015 American Chemical Society). (b) Chain‐growth CuAAC polymerization of AB2 monomers in solution (Reprinted from Shi et al. (2015). Copyright 2015 Wiley‐VCH). (c) Chain‐growth polymerization of inimer in solution
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Step‐growth versus chain‐growth polymerization in synthesis of hyperbranched polymer with labeled dendritic (D), linear (L), and terminal (T) structural units
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Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Implantable Materials and Surgical Technologies > Nanomaterials and Implants

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