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Recent advances in applications of nanoparticles in SERS in vivo imaging

Advanced Review

Min Zhou, Danni Zhong, Jian He, Yuchen Qi, Zhen Du

Published Online: Oct 19 2020

DOI: 10.1002/wnan.1672

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Abstract Surface‐enhanced Raman scattering (SERS) technique has been regarded as one of the most important research methods in the field of single‐molecule science. Since the previous decade, the application of nanoparticles for in vivo SERS imaging becomes the focus of research. To enhance the performance of SERS imaging, researchers have developed several SERS nanotags such as gold nanostars, copper‐based nanomaterials, semiconducting quantum dots, and so on. The development of Raman equipment is also necessary owing to the current limitations. This review describes the recent advances of SERS nanoparticles and their applications for in vivo imaging in detail. Specific examples highlighting the in vivo cancer imaging and treatment application of SERS nanoparticles. A perspective on the challenges and opportunities of nanoparticles in SERS in vivo imaging is also provided. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

Schematic illustration of SERS‐based direct detection and indirect detection. (Reprinted with permission from B. Ren et al., Copyright 2015 John Wiley and Sons)

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(a) Following stimulation, CAEC express adhesion molecules detectable via immuno‐SERS imaging in multiplex formats, and the representative spectra from anti‐ICAM‐1 (purple), anti‐VCAM‐1 (red) and anti‐P‐selectin (blue) BFNP. (b) SERS spectroscopy was conducted on atherosclerotic (red lines) and nonatherosclerotic (black lines) regions of the intact artery. (c) SERS mapping of anti‐ICAM‐1 (purple), anti‐VCAM‐1 (red), anti‐P‐selectin (blue), and isotype (green) BFNPs in nonatherosclerotic (up) and atherosclerotic (down) artery. Scale bars: 500 μm (black bar) and 20 μm (white bar). (d) To conduct SERS‐BFNP molecular imaging. (e) SERS spectra acquired from mice that received a mixture of BFNPs. (Reprinted with permission from P. Maffia et al., Copyright 2018 Ivyspring International Publisher). CAEC, coronary artery endothelial cells; ICAM‐1, intercellular adhesion molecule 1; VCAM‐1, vascular cell adhesion molecule 1; BFNPs, antibody‐functionalized gold nanoprobes

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(a) Illustration of gold nanostars for intracellular and in vivo SERS detection and real‐time drug delivery using plasmonic‐tunable Raman/FTIR imaging. This system can directly track the delivery and release of MTX from gold nanostars in single living cells and in mice in real‐time manner. (Reprinted with permission from D. Cui et al., Copyright 2016 Elsevier). MTX, mitoxantrone

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(a) Schematic illustration of the intraoperative precise SERS imaging and the thermal ablation of residual microtumors in the orthotopic prostate metastasis tumor model. (b) Temperature change curves of GERTs solution and water with an 808 nm laser irradiation. (c) The experimental process of intraoperative Raman imaging‐guided photothermal ablation of residual microtumors. (d) The digital photograph and Raman imaging of tumors before or after surgical resection. Raman image clearly shows multiple residual microtumors on the resection bed (Arrow 1) or metastasized to the bladder (Arrow 2). Arrow 3 indicates the signal from normal bladder tissue. GERTs‐positive foci are confirmed to be microscopic tumor cell deposits by H&E staining. (Reprinted with permission from Z. Xiao et al., Copyright 2018 American Chemical Society). GERTs, gap‐enhanced Raman tags

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(a) Illustration of the SERS NP. (b) TEM imaging of the SERS NPs. (c) SERS spectrum of the NPs depends on the Raman reporter molecule (trans −1,2‐bis(4 pyridyl)ethylene (BPE)). (d) SERS NPs enable delineation of liver tumors and microscopic liver tumors by MRI and SERS imaging. (e) Comparison of SERS NPs versus ICG as contrast agents in vivo. The two contrast agents have similar performance when demarcating the tumors. However, the ICG exhibits a false positive area indicated by the arrowhead. (Reprinted with permission from M. Kircher et al., Copyright 2016 American Chemical Society). TEM, transmission electron microscopy; ICG, indocyanine green

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(a) Synthesis of UCF‐SERS dots and their UCF and SERS dual mode imaging. (b) TEM image of [email protected]₂@Ag nanocomposites. (c) Normal and fluorescence images of UCF‐SERS dots solution (0.65 mg ml⁻¹). (d) Fluorescence images of the different thickness pork tissue slices blocked UCF‐SERS Dots solution. (e) UCF and SERS spectra of the UCF‐SERS dots subcutaneously injected Kunming rat under 980 nm (0.5 W/cm²) and 785 nm ((200 mW) laser excitation, respectively. (Reprinted with permission from L. Chen et al., Copyright 2014 American Chemical Society). UCF, upconversion fluorescence; UCNP, upconversion nanoparticles

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(a) Schematic of the endoscopic imaging of a rat esophageal tumor model. (b) Photograph of a surgically exposed rat esophagus implanted with three tumor xenografts. (c) Raman spectrum of the SERS NPs that were mixed together. (d) Raman spectrum of a variety of backgrounds. (e) Images showing the concentration ratio of EGFR‐NPs versus isotype‐NPs and HER2‐NPs versus isotype‐NPs. (Reprinted with permission from J. Liu et al., Copyright 2015 Optical Society of America)

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(a) Typical TEM images of Au nanostars, synthesized via addition of 135 μl of Au seed (main image, Scale bar is 50 nm) and 45 μl of Au seed (inset, Scale bar is 100 nm). (Reprinted with permission from T. Vo‐Dinh et al., Copyright 2008 American Chemical Society). (b) The porous Au–Ag alloy NPs and their SERS activities. (Reprinted with permission from C. Gao et al., Copyright 2016 American Chemical Society). (c) Schematic diagram and TEM image of gap‐enhanced Raman tags. Scale bar is 50 nm. (Reprinted with permission from Z. Xiao et al., Copyright 2018 American Chemical Society). Au–Ag alloy NPs, gold−silver alloy nanoparticles

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The structure of a SERS nanotag, consisting of a SERS‐active nanoparticle core, adsorbed Raman probe molecules on the surface, and a biocompatible layer

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References

Agostinis,, P., Berg,, K., Cengel,, K. A., Foster,, T. H., Girotti,, A. W., Gollnick,, S. O., … Golab,, J. (2011). Photodynamic therapy of cancer: An update. CA: A Cancer Journal for Clinicians, 61(4), 250–281.
Amendola,, V., Scaramuzza,, S., Litti,, L., Meneghetti,, M., Zuccolotto,, G., Rosato,, A., … Colombatti,, M. (2014). Magneto‐plasmonic Au‐Fe alloy nanoparticles designed for multimodal SERS‐MRI‐CT imaging. Small, 10(12), 2476–2486.
Ando,, J., Fujita,, K., Smith,, N. I., & Kawata,, S. (2011). Dynamic SERS imaging of cellular transport pathways with endocytosed gold nanoparticles. Nano Letters, 11(12), 5344–5348.
Andreou,, C., Neuschmelting,, V., Tschaharganeh,, D. F., Huang,, C. H., Oseledchyk,, A., Iacono,, P., … Kircher,, M. F. (2016). Imaging of liver Tumors using surface‐enhanced Raman scattering nanoparticles. ACS Nano, 10(5), 5015–5026.
Bedics,, M. A., Kearns,, H., Cox,, J. M., Mabbott,, S., Ali,, F., Shand,, N. C., … Detty,, M. R. (2015). Extreme red shifted SERS nanotags. Chemical Science, 6(4), 2302–2306.
Bucci,, M. K., Maity,, A., Janss,, A. J., Belasco,, J. B., Fisher,, M. J., Tochner,, Z. A., … Shu,, H. K. (2004). Near complete surgical resection predicts a favorable outcome in pediatric patients with nonbrainstem, malignant gliomas: Results from a single center in the magnetic resonance imaging era. Cancer, 101(4), 817–824.
Burger,, R. A., Brady,, M. F., Bookman,, M. A., Fleming,, G. F., Monk,, B. J., Huang,, H., … Gynecologic Oncology,, G. (2011). Incorporation of bevacizumab in the primary treatment of ovarian cancer. The New England Journal of Medicine, 365(26), 2473–2483.
Cha,, M. G., Lee,, S., Park,, S., Kang,, H., Lee,, S. G., Jeong,, C., … Jeong,, D. H. (2017). A dual modal silver bumpy nanoprobe for photoacoustic imaging and SERS multiplexed identification of in vivo lymph nodes. Nanoscale, 9(34), 12556–12564.
Chen,, C., Ni,, X., Jia,, S., Liang,, Y., Wu,, X., Kong,, D., & Ding,, D. (2019). Massively evoking immunogenic cell death by focused mitochondrial oxidative stress using an AIE Luminogen with a twisted molecular structure. Advanced Materials, 31(52), e1904914.
Chen,, C., Ni,, X., Tian,, H. W., Liu,, Q., Guo,, D. S., & Ding,, D. (2020). Calixarene‐based supramolecular AIE dots with highly inhibited nonradiative decay and intersystem crossing for ultrasensitive fluorescence image‐guided cancer surgery. Angewandte Chemie International Edition, 59(25), 10008–10012.
Chen,, C., Ou,, H., Liu,, R., & Ding,, D. (2020). Regulating the Photophysical property of organic/polymer optical agents for promoted cancer Phototheranostics. Advanced Materials, 32(3), e1806331.
Chow,, E. K.‐H., & Ho,, D. (2013). Cancer nanomedicine: From drug delivery to imaging. Science Translational Medicine, 5(216), 216rv4.
Ding,, S. Y., Yi,, J., Li,, J. F., Ren,, B., Wu,, D. Y., Panneerselvam,, R., & Tian,, Z. Q. (2016). Nanostructure‐based plasmon‐enhanced Raman spectroscopy for surface analysis of materials. Nature Reviews Materials, 1(6), 16021.
Dykman,, L., & Khlebtsov,, N. (2012). Gold nanoparticles in biomedical applications: Recent advances and perspectives. Chemical Society Reviews, 41(6), 2256–2282.
Fabris,, L. (2015). Gold‐based SERS tags for biomedical imaging. Journal of Optics, 17(11), 14.
Fales,, A. M., Yuan,, H., & Vo‐Dinh,, T. (2011). Silica‐coated gold nanostars for combined surface‐enhanced Raman scattering (SERS) detection and singlet‐oxygen generation: A potential nanoplatform for theranostics. Langmuir, 27(19), 12186–12190.
Fales,, A. M., Yuan,, H., & Vo‐Dinh,, T. (2013). Cell‐penetrating peptide enhanced intracellular Raman imaging and photodynamic therapy. Molecular Pharmaceutics, 10(6), 2291–2298.
Fan,, M., Andrade,, G. F., & Brolo,, A. G. (2011). A review on the fabrication of substrates for surface enhanced Raman spectroscopy and their applications in analytical chemistry. Analytica Chimica Acta, 693(1–2), 7–25.
Fleischmann,, M., Hendra,, P. J., & Mcquillan,, A. J. (1974). Raman‐spectra of pyridine adsorbed at a silver electrode. Chemical Physics Letters, 26(2), 163–166.
Gao,, Y., Li,, Y., Chen,, J., Zhu,, S., Liu,, X., Zhou,, L., … Shi,, J. (2015). Multifunctional gold nanostar‐based nanocomposite: Synthesis and application for noninvasive MR‐SERS imaging‐guided photothermal ablation. Biomaterials, 60, 31–41.
Garai,, E., Sensarn,, S., Zavaleta,, C. L., Van de Sompel,, D., Loewke,, N. O., Mandella,, M. J., … Contag,, C. H. (2013). High‐sensitivity, real‐time, ratiometric imaging of surface‐enhanced Raman scattering nanoparticles with a clinically translatable Raman endoscope device. Journal of Biomedical Optics, 18(9), 096008.
Garcia‐Garcia,, H. M., Jang,, I. K., Serruys,, P. W., Kovacic,, J. C., Narula,, J., & Fayad,, Z. A. (2014). Imaging plaques to predict and better manage patients with acute coronary events. Circulation Research, 114(12), 1904–1917.
Gebitekin,, C., Gupta,, N., Satur,, C., Olgac,, G., Martin,, P., Saunders,, N., & Walker,, D. (1994). Fate of patients with residual tumour at the bronchial resection margin. European Journal of Cardio‐Thoracic Surgery, 8(7), 339–343.
Han,, X. X., Ji,, W., Zhao,, B., & Ozaki,, Y. (2017). Semiconductor‐enhanced Raman scattering: Active nanomaterials and applications. Nanoscale, 9(15), 4847–4861.
Harmsen,, S., Huang,, R., Wall,, M. A., Karabeber,, H., Samii,, J. M., Spaliviero,, M., … Kircher,, M. F. (2015). Surface‐enhanced resonance Raman scattering nanostars for high‐precision cancer imaging. Science Translational Medicine, 7(271), 271ra277.
He,, J., Qiao,, Y., Zhang,, H., Zhao,, J., Li,, W., Xie,, T., … Zhou,, M. (2020). Gold‐silver nanoshells promote wound healing from drug‐resistant bacteria infection and enable monitoring via surface‐enhanced Raman scattering imaging. Biomaterials, 234, 119763.
Hui,, Y., Yi,, X., Hou,, F., Wibowo,, D., Zhang,, F., Zhao,, D., … Zhao,, C. X. (2019). Role of nanoparticle mechanical properties in cancer drug delivery. ACS Nano, 13(7), 7410–7424.
Jeanmaire,, D. L., & Van Duyne,, R. P. (1977). Surface raman spectroelectrochemistry. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 84(1), 1–20.
Ji,, W., Zhao,, B., & Ozaki,, Y. (2016). Semiconductor materials in analytical applications of surface‐enhanced Raman scattering. Journal of Raman Spectroscopy, 47(1), 51–58.
Jimenez de Aberasturi,, D., Serrano‐Montes,, A. B., Langer,, J., Henriksen‐Lacey,, M., Parak,, W. J., & Liz‐Marzán,, L. M. (2016). Surface enhanced Raman scattering encoded gold Nanostars for multiplexed cell discrimination. Chemistry of Materials, 28(18), 6779–6790.
Jokerst,, J. V., Cole,, A. J., Van de Sompel,, D., & Gambhir,, S. S. (2012). Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice. ACS Nano, 6(11), 10366–10377.
Karabeber,, H., Huang,, R., Iacono,, P., Samii,, J. M., Pitter,, K., Holland,, E. C., & Kircher,, M. F. (2014). Guiding brain tumor resection using surface‐enhanced Raman scattering nanoparticles and a hand‐held Raman scanner. ACS Nano, 8(10), 9755–9766.
Kearns,, H., Ali,, F., Bedics,, M. A., Shand,, N. C., Faulds,, K., Detty,, M. R., & Graham,, D. (2017). Sensitive SERS nanotags for use with a hand‐held 1064 nm Raman spectrometer. Royal Society Open Science, 4(7), 170422.
Keefe,, A. D., Pai,, S., & Ellington,, A. (2010). Aptamers as therapeutics. Nature Reviews Drug Discovery, 9(7), 537–550.
Kennedy,, L. C., Bickford,, L. R., Lewinski,, N. A., Coughlin,, A. J., Hu,, Y., Day,, E. S., … Drezek,, R. A. (2011). A new era for cancer treatment: Gold‐nanoparticle‐mediated thermal therapies. Small, 7(2), 169–183.
Keren,, S., Zavaleta,, C., Cheng,, Z., de la Zerda,, A., Gheysens,, O., & Gambhir,, S. S. (2008). Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 105(15), 5844–5849.
Khoury,, C. G., & Vo‐Dinh,, T. (2008). Gold Nanostars for surface‐enhanced Raman scattering: Synthesis, characterization and optimization. Journal of Physical Chemistry C: Nanomaterials and Interfaces, 2008(112), 18849–18859.
Kircher,, M. F., de la Zerda,, A., Jokerst,, J. V., Zavaleta,, C. L., Kempen,, P. J., Mittra,, E., … Gambhir,, S. S. (2012). A brain tumor molecular imaging strategy using a new triple‐modality MRI‐photoacoustic‐Raman nanoparticle. Nature Medicine, 18(5), 829–834.
Kneipp,, K., Wang,, Y., Kneipp,, H., Perelman,, L. T., Itzkan,, I., Dasari,, R., & Feld,, M. S. (1997). Single molecule detection using surface‐enhanced Raman scattering (SERS). Physical Review Letters, 78(9), 1667–1670.
Kunjachan,, S., Ehling,, J., Storm,, G., Kiessling,, F., & Lammers,, T. (2015). Noninvasive imaging of nanomedicines and Nanotheranostics: Principles, Progress, and prospects. Chemical Reviews, 115(19), 10907–10937.
Lammers,, T., Aime,, S., Hennink,, W. E., Storm,, G., & Kiessling,, F. (2011). Theranostic nanomedicine. Accounts of Chemical Research, 44(10), 1029–1038.
Lane,, L. A., Qian,, X., & Nie,, S. (2015). SERS nanoparticles in medicine: From label‐free detection to spectroscopic tagging. Chemical Reviews, 115(19), 10489–10529.
Lane,, L. A., Xue,, R., & Nie,, S. (2018). Emergence of two near‐infrared windows for in vivo and intraoperative SERS. Current Opinion in Chemical Biology, 45, 95–103.
Li,, J. F., Zhang,, Y. J., Ding,, S. Y., Panneerselvam,, R., & Tian,, Z. Q. (2017). Core‐Shell nanoparticle‐enhanced Raman spectroscopy. Chemical Reviews, 117(7), 5002–5069.
Li,, M., Wu,, J., Ma,, M., Feng,, Z., Mi,, Z., Rong,, P., & Liu,, D. (2019). Alkyne‐ and nitrile‐anchored gold nanoparticles for multiplex SERS imaging of biomarkers in cancer cells and tissues. Nano, 3(1), 113–119.
Lim,, D. K., Jeon,, K. S., Kim,, H. M., Nam,, J. M., & Suh,, Y. D. (2010). Nanogap‐engineerable Raman‐active nanodumbbells for single‐molecule detection. Nature Materials, 9(1), 60–67.
Ling,, X., Xie,, L., Fang,, Y., Xu,, H., Zhang,, H., Kong,, J., … Liu,, Z. (2010). Can graphene be used as a substrate for Raman enhancement? Nano Letters, 10(2), 553–561.
Liu,, D., Yang,, F., Xiong,, F., & Gu,, N. (2016). The smart drug delivery system and its clinical potential. Theranostics, 6(9), 1306–1323.
Liu,, J., Zheng,, T., & Tian,, Y. (2019). Functionalized h‐BN Nanosheets as a Theranostic platform for SERS real‐time monitoring of MicroRNA and photodynamic therapy. Angewandte Chemie International Edition, 58(23), 7757–7761.
Liu,, K., Bai,, Y., Zhang,, L., Yang,, Z., Fan,, Q., Zheng,, H., … Gao,, C. (2016). Porous Au‐Ag Nanospheres with high‐density and highly accessible hotspots for SERS analysis. Nano Letters, 16(6), 3675–3681.
Livingstone,, R., Zhou,, X., Tamargo,, M. C., Lombardi,, J. R., Quagliano,, L. G., & Jean‐Mary,, F. (2010). Surface enhanced Raman spectroscopy of pyridine on CdSe/ZnBeSe quantum dots grown by molecular beam epitaxy. The Journal of Physical Chemistry C, 114(41), 17460–17464.
Lucky,, S. S., Soo,, K. C., & Zhang,, Y. (2015). Nanoparticles in photodynamic therapy. Chemical Reviews, 115(4), 1990–2042.
Lyon,, L. A., Keating,, C. D., Fox,, A. P., Baker,, B. E., He,, L., Nicewarner,, S. R., … Natan,, M. J. (1998). Raman spectroscopy. Analytical Chemistry, 70(12), 341R–361R.
Maeda,, H. (2001). The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor‐selective macromolecular drug targeting. Advances in Enzyme Regulation, 41(1), 189–207.
Makuuchi,, M., Kosuge,, T., Takayama,, T., Yamazaki,, S., Kakazu,, T., Miyagawa,, S., & Kawasaki,, S. (1993). Surgery for small liver cancers. Seminars in Surgical Oncology, 9(4), 298–304.
Meng,, H., & Wei,, R. (2015). Use of smart designed nanoparticles to impact cancer surgery. Science Bulletin, 60(1), 142–143.
Mohs,, A. M., Mancini,, M. C., Singhal,, S., Provenzale,, J. M., Leyland‐Jones,, B., Wang,, M. D., & Nie,, S. (2010). Hand‐held spectroscopic device for in vivo and intraoperative tumor detection: Contrast enhancement, detection sensitivity, and tissue penetration. Analytical Chemistry, 82(21), 9058–9065.
Montjoy,, D. G., Bahng,, J. H., Eskafi,, A., Hou,, H., & Kotov,, N. A. (2018). Omnidispersible hedgehog particles with multilayer coatings for multiplexed biosensing. Journal of the American Chemical Society, 140(25), 7835–7845.
Mura,, S., Nicolas,, J., & Couvreur,, P. (2013). Stimuli‐responsive nanocarriers for drug delivery. Nature Materials, 12(11), 991–1003.
Nair,, R. V., Santhakumar,, H., & Jayasree,, R. S. (2018). Gold nanorods decorated with a cancer drug for multimodal imaging and therapy. Faraday Discussions, 207(0), 423–435.
Nalbant Esenturk,, E., & Hight Walker,, A. R. (2009). Surface‐enhanced Raman scattering spectroscopy via gold nanostars. Journal of Raman Spectroscopy, 40(1), 86–91.
Nam,, J. M., Oh,, J. W., Lee,, H., & Suh,, Y. D. (2016). Plasmonic Nanogap‐enhanced Raman scattering with nanoparticles. Accounts of Chemical Research, 49(12), 2746–2755.
Ni,, X., Zhang,, X., Duan,, X., Zheng,, H. L., Xue,, X. S., & Ding,, D. (2019). Near‐infrared afterglow luminescent aggregation‐induced emission dots with ultrahigh tumor‐to‐liver signal ratio for promoted image‐guided cancer surgery. Nano Letters, 19(1), 318–330.
Niu,, X., Chen,, H., Wang,, Y., Wang,, W., Sun,, X., & Chen,, L. (2014). Upconversion fluorescence‐SERS dual‐mode tags for cellular and in vivo imaging. ACS Applied Materials %26 Interfaces, 6(7), 5152–5160.
Noonan,, J., Asiala,, S. M., Grassia,, G., MacRitchie,, N., Gracie,, K., Carson,, J., … Maffia,, P. (2018). In vivo multiplex molecular imaging of vascular inflammation using surface‐enhanced Raman spectroscopy. Theranostics, 8(22), 6195–6209.
Oseledchyk,, A., Andreou,, C., Wall,, M. A., & Kircher,, M. F. (2017). Folate‐targeted surface‐enhanced resonance Raman scattering Nanoprobe Ratiometry for detection of microscopic ovarian cancer. ACS Nano, 11(2), 1488–1497.
Pal,, S., Harmsen,, S., Oseledchyk,, A., Hsu,, H. T., & Kircher,, M. F. (2017). MUC1 aptamer targeted SERS Nanoprobes. Advanced Functional Materials, 27(32), 1606632.
Palonpon,, A. F., Ando,, J., Yamakoshi,, H., Dodo,, K., Sodeoka,, M., Kawata,, S., & Fujita,, K. (2013). Raman and SERS microscopy for molecular imaging of live cells. Nature Protocols, 8(4), 677–692.
Park,, J. H., von Maltzahn,, G., Ong,, L. L., Centrone,, A., Hatton,, T. A., Ruoslahti,, E., … Sailor,, M. J. (2010). Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery. Advanced Materials, 22(8), 880–885.
Qian,, X., Peng,, X. H., Ansari,, D. O., Yin‐Goen,, Q., Chen,, G. Z., Shin,, D. M., … Nie,, S. (2008). In vivo tumor targeting and spectroscopic detection with surface‐enhanced Raman nanoparticle tags. Nature Biotechnology, 26(1), 83–90.
Qiu,, X., You,, X., Chen,, X., Chen,, H., Dhinakar,, A., Liu,, S., … Liu,, Z. (2017). Development of graphene oxide‐wrapped gold nanorods as robust nanoplatform for ultrafast near‐infrared SERS bioimaging. International Journal of Nanomedicine, 12, 4349–4360.
Qiu,, Y., Zhang,, Y., Li,, M., Chen,, G., Fan,, C., Cui,, K., … Xiao,, Z. (2018). Intraoperative detection and eradication of residual Microtumors with gap‐enhanced Raman tags. ACS Nano, 12(8), 7974–7985.
Quagliano,, L. G. (2004). Observation of molecules adsorbed on III‐V semiconductor quantum dots by surface‐enhanced Raman scattering. Journal of the American Chemical Society, 126(23), 7393–7398.
Raman,, C. V., & Krishnan,, K. S. (1928). A new type of secondary radiation. Nature, 121(3048), 501–502.
Rwei,, A. Y., Wang,, W., & Kohane,, D. S. (2015). Photoresponsive nanoparticles for drug delivery. Nano Today, 10(4), 451–467.
Schlucker,, S. (2014). Surface‐enhanced Raman spectroscopy: Concepts and chemical applications. Angewandte Chemie International Edition, 53(19), 4756–4795.
Shao,, D., Zhang,, X., Liu,, W., Zhang,, F., Zheng,, X., Qiao,, P., … Chen,, L. (2016). Janus Silver‐mesoporous silica Nanocarriers for SERS traceable and pH‐sensitive drug delivery in cancer therapy. ACS Applied Materials %26 Interfaces, 8(7), 4303–4308.
Sharma,, B., Frontiera,, R. R., Henry,, A. I., Ringe,, E., & Van Duyne,, R. P. (2012). SERS: Materials, applications, and the future. Materials Today, 15(1–2), 16–25.
Shkilnyy,, A., Souce,, M., Dubois,, P., Warmont,, F., Saboungi,, M. L., & Chourpa,, I. (2009). Poly(ethylene glycol)‐stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy. Analyst, 134(9), 1868–1872.
Song,, C., Li,, F., Guo,, X., Chen,, W., Dong,, C., Zhang,, J., … Wang,, L. (2019). Gold nanostars for cancer cell‐targeted SERS‐imaging and NIR light‐triggered plasmonic photothermal therapy (PPTT) in the first and second biological windows. Journal of Materials Chemistry B, 7(12), 2001–2008.
Strozyk,, M. S., Jimenez de Aberasturi,, D., & Liz‐Marzan,, L. M. (2018). Composite polymer colloids for SERS‐based applications. The Chemical Record, 18(7–8), 807–818.
Tian,, F., Conde,, J., Bao,, C., Chen,, Y., Curtin,, J., & Cui,, D. (2016). Gold nanostars for efficient in vitro and in vivo real‐time SERS detection and drug delivery via plasmonic‐tunable Raman/FTIR imaging. Biomaterials, 106, 87–97.
Tian,, G., Gu,, Z., Zhou,, L., Yin,, W., Liu,, X., Yan,, L., … Zhao,, Y. (2012). Mn2+ dopant‐controlled synthesis of NaYF4:Yb/Er upconversion nanoparticles for in vivo imaging and drug delivery. Advanced Materials, 24(9), 1226–1231.
Toms,, S. A., Lin,, W. C., Weil,, R. J., Johnson,, M. D., Jansen,, E. D., & Mahadevan‐Jansen,, A. (2007). Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity. Neurosurgery, 61(1 Suppl, 327–335.
Vahrmeijer,, A. L., Hutteman,, M., van der Vorst,, J. R., van de Velde,, C. J., & Frangioni,, J. V. (2013). Image‐guided cancer surgery using near‐infrared fluorescence. Nature Reviews Clinical Oncology, 10(9), 507–518.
von Maltzahn,, G., Centrone,, A., Park,, J. H., Ramanathan,, R., Sailor,, M. J., Hatton,, T. A., & Bhatia,, S. N. (2009). SERS‐coded gold nanorods as a multifunctional platform for densely multiplexed near‐infrared imaging and photothermal heating. Advanced Materials, 21(31), 3175–3180.
Wang,, C., Chen,, Y., Wang,, T., Ma,, Z., & Su,, Z. (2008). Monodispersed gold Nanorod‐embedded silica particles as novel Raman labels for biosensing. Advanced Functional Materials, 18(2), 355–361.
Wang,, J., Liang,, D., Jin,, Q., Feng,, J., & Tang,, X. (2020). Bioorthogonal SERS Nanotags as a precision theranostic platform for in vivo SERS imaging and cancer Photothermal therapy. Bioconjugate Chemistry, 31(2), 182–193.
Wang,, Y., & Schlucker,, S. (2013). Rational design and synthesis of SERS labels. Analyst, 138(8), 2224–2238.
Wang,, Y. W., Kang,, S., Khan,, A., Bao,, P. Q., & Liu,, J. T. (2015). In vivo multiplexed molecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles. Biomedical Optics Express, 6(10), 3714–3723.
Xu,, H. X., Bjerneld,, E. J., Kall,, M., & Borjesson,, L. (1999). Spectroscopy of single hemoglobin molecules by surface enhanced Raman scattering. Physical Review Letters, 83(21), 4357–4360.
Yigit,, M. V., Zhu,, L., Ifediba,, M. A., Zhang,, Y., Carr,, K., Moore,, A., & Medarova,, Z. (2011). Noninvasive MRI‐SERS imaging in living mice using an innately bimodal nanomaterial. ACS Nano, 5(2), 1056–1066.
Yuan,, H., Fales,, A. M., & Vo‐Dinh,, T. (2012). TAT peptide‐functionalized gold nanostars: Enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance. Journal of the American Chemical Society, 134(28), 11358–11361.
Yuan,, H., Liu,, Y., Fales,, A. M., Li,, Y. L., Liu,, J., & Vo‐Dinh,, T. (2013). Quantitative surface‐enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection. Analytical Chemistry, 85(1), 208–212.
Zavaleta,, C. L., Smith,, B. R., Walton,, I., Doering,, W., Davis,, G., Shojaei,, B., … Gambhir,, S. S. (2009). Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 106(32), 13511–13516.
Zhang,, Y., Qian,, J., Wang,, D., Wang,, Y., & He,, S. (2013). Multifunctional gold nanorods with ultrahigh stability and tunability for in vivo fluorescence imaging, SERS detection, and photodynamic therapy. Angewandte Chemie International Edition, 52(4), 1148–1151.
Zhang,, Y., Zhen,, Y. R., Neumann,, O., Day,, J. K., Nordlander,, P., & Halas,, N. J. (2014). Coherent anti‐stokes Raman scattering with single‐molecule sensitivity using a plasmonic Fano resonance. Nature Communications, 5, 4424.
Zheng,, X. S., Hu,, P., Cui,, Y., Zong,, C., Feng,, J. M., Wang,, X., & Ren,, B. (2014). BSA‐coated nanoparticles for improved SERS‐based intracellular pH sensing. Analytical Chemistry, 86(24), 12250–12257.

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