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WIREs Nanomed Nanobiotechnol
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Stimuli‐responsive polypeptide nanoassemblies: Recent progress and applications in cancer nanomedicine

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Abstract Stimuli‐responsive polypeptide nanoassemblies exhibit great potentials for cancer nanomedicines because of desirable biocompatibility and biodegradability, unique secondary conformations, varying functionalities, and especially the stimuli‐enhanced therapeutic efficacy and reduced side effect. This review introduces the design and fabrication of stimuli‐responsive polypeptide nanoassemblies that exhibit endogenous stimuli (e.g., pH, reduction, reactive oxygen species, adenosine triphosphate and enzyme, etc.) and exogenous light stimuli (e.g., UV and near‐infrared light), which are biologically related or applied in the clinic. We also discuss the applications and prospects of those stimuli‐responsive polypeptide nanoassemblies that might overcome the biological barriers of cancer nanomedicines for in vivo administration. Much more effort is needed to accelerate the second‐generation stimuli‐responsive polypeptide nanomedicines for clinical transition and applications. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
(a) Illustration for the preparation and drug delivery of pHe/reduction dual‐responsive CPT‐loaded CCL nanoparticles, (b) the size dependence on incubation time of CCL79 under different stimuli, and (c) dual‐stimuli‐triggered CPT release profiles of CPT‐loaded CCL79. Reprinted with permission from Ding et al. (2018). Copyright 2018. Royal Society of Chemistry. (d) Illustration of targeted and pH‐triggered zwitterionic polypeptide nanoparticles p(EK‐co‐C‐SPA + DOX). Reprinted with permission from Xue et al. (2020). Copyright 2020. American Chemical Society
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Schematic illustration of the NIR‐II Imaging‐guided cancer PTT by the PF nanoparticles. Reprinted with permission from Li et al. (2019). Copyright 2019. American Chemical Society
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Schematic description of morphologic transformation of polypeptide vesicles (PNBC‐b‐PEG) under different stimuli. Reprinted with permission from G. Liu, Zhou, Guan, et al. (2014a). Copyright 2014. Wiley Online Library
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Illustration for the fabrication and functional distinction of non‐crosslinked and light‐triggered core‐crosslinked drug‐loaded micelles. Reprinted with permission from Shao et al. (2014). Copyright 2014. American Chemical Society
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Illustration for the process of pDNA release by intracellular pH/ATP dual‐responsive FPBA/GlcAm‐cross‐linked PMs. Reprinted with permission from Yoshinaga et al. (2017). Copyright 2017. American Chemical Society
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(a) Schematic illustration of the MMP enzyme/ROS dually responsive MLMP drug delivery system. (b) Apoptosis analysis of NCI‐H460 cells treated with different groups. (c) The curves of tumor volume changes after treating with different groups. Reprinted with permission from Yoo et al. (2017). Copyright 2017. Elsevier
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Schematic diagrams of amphiphilic copolymers loading drugs by (a) hydrophobic interaction and (b) donor‐acceptor interaction. Reprinted with permission from Lv et al. (2018). Copyright 2018. American Chemical Society
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(a) Schematic illustration of the charge reversal and self‐amplifiable drug release of PPT/D(DMA)@DOX in vivo. (b) Ex vivo fluorescence imaging for main organs and tumor in different groups. (c) Tumor volume over the treatment time. Reprinted with permission from X. Zhang, Zhu, et al. (2020). Copyright 2020. Springer Nature
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Illustration for the fabrication of shell‐stacked nanoparticles of SNP and a sequentially responsive drug release in tumor cells. Reprinted with permission from Chen et al. (2017). Copyright 2017. WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
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(a) Scheme for the synthesis of cRGD‐rPTM‐Dox micelles and their targeted drug delivery. (b) Drug release from cRGD‐rPTM‐Dox under different conditions. Reprinted with permission from Xue et al. (2018). Copyright 2018. American Chemical Society. (C) Illustration for the fabrication of DOX‐loaded disulfide crosslinked polypeptide micelles from PC‐g‐PEG. Reprinted with permission from Wu et al. (2016). Copyright 2016. Royal Society of Chemistry
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Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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