Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 7.689

Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Abstract A full understanding of the pharmacokinetic parameters describing nanomaterial disposition in the body would greatly facilitate development of a firm foundation upon which risk assessment could be based. This review focuses on the disposition of carbon based fullerenes and nanotubes, as well as quantum dots (QD) after parenteral administration to primarily rodents. The common theme across all particle types is that a major determinant of nanomaterial disposition is the degree of interaction with the reticuloendothelial (RE) cell system. Small water‐soluble particles evading this system may be excreted by the kidney. Larger particles and those with the proper surface charge may get targeted to RE cells in the liver, spleen and other organs. Most nanomaterial kinetics are characterized by relatively short blood half‐lives reflecting tissue extraction and not by clearance from the body. In fact, another common attribute to nanomaterial kinetics is retention of particles in the body. Finally, unlike many small organic drugs, nanomaterials may preferentially be trafficked in the body via the lymphatic system that has obvious immunological implications. Copyright © 2008 John Wiley & Sons, Inc. This article is categorized under: Nanotechnology Approaches to Biology > Cells at the Nanoscale

This WIREs title offers downloadable PowerPoint presentations of figures for non-profit, educational use, provided the content is not modified and full credit is given to the author and publication.

Download a PowerPoint presentation of all images


Stages involved in absorption, distribution, metabolism and elimination (ADME).

[ Normal View | Magnified View ]

Related Articles

Pharmacokinetics of metallic nanoparticles
Characterization of nanomaterials for toxicity assessment
Fullerenes: formation, stability, and reactivity (WIREs WIREs Computational Molecular Science)
American Society for Nanomedicine, 2010 Conference

Browse by Topic

Nanotechnology Approaches to Biology > Cells at the Nanoscale

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts