This Title All WIREs
How to cite this WIREs title:
Impact Factor: 9.957

IRES mediated translational regulation of p53 isoforms

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

p53 is a well known tumor suppressor protein that plays a critical role in cell cycle arrest and apoptosis. It has several isoforms which are produced by transcriptional and posttranscriptional regulatory mechanisms. p53 mRNA has been demonstrated to be translated into two isoforms, full‐length p53 (FL‐p53) and a truncated isoform ΔN‐p53 by the use of alternative translation initiation sites. The mechanism of translation regulation of these two isoforms was further elucidated by the discovery of IRES elements in the p53 mRNA. These two IRESs were shown to regulate the translation of p53 and ΔN‐p53 in a distinct cell‐cycle phase‐dependent manner. This review focuses on the current understanding of the regulation of p53 IRES mediated translation and the role of cis and trans acting factors that influence expression of p53 isoforms. WIREs RNA 2014, 5:131–139. doi: 10.1002/wrna.1202 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Recognition RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications Translation > Translation Regulation

This WIREs title offers downloadable PowerPoint presentations of figures for non-profit, educational use, provided the content is not modified and full credit is given to the author and publication.

Download a PowerPoint presentation of all images

Schematic representation of p53 mRNA showing two IRES elements. The two AUG codons are depicted in p53mRNA, first AUG positioned after 134nts responsible for full length p53 (FL‐p53), second AUG positioned after 251nts responsible for ΔN‐p53 synthesis.
[ Normal View | Magnified View ]
Representation of proposed regulation of p53 IRES mediated translation. During stress and physiological conditions IRES trans‐acting factors (green: DAP5, brown: hnRNPC1/C2, purple: PTB, yellow: ANXA2, and red: RPL26) come out from nucleus to cytoplasm to enhance IRES activity.
[ Normal View | Magnified View ]
(a) p53 translation regulation. ITAFs binding to the IRESs (purple: PTB, yellow: ANXA2, red: hnRNPC1/C2, and green: PSF) enhances translation. miRNAs binding to p53 3′UTR inhibits translation. (b) Circularization of p53 mRNA helps in translation. (1) Circularization of p53 mRNA through PABP and cap of mRNA. (2) 5′–3′UTR interaction with help of RPL26.
[ Normal View | Magnified View ]

Browse by Topic

Translation > Translation Regulation
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
RNA Interactions with Proteins and Other Molecules > Protein–RNA Recognition

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts