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MicroRNA in skeletal muscle development, growth, atrophy, and disease

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MicroRNAs (miRNAs) are short noncoding RNAs that are important global‐ as well as tissue‐ and cell‐type‐specific regulators of gene expression. Muscle‐specific miRNAs or myomirs have been shown to control various processes in skeletal muscles, from myogenesis and muscle homeostasis to different responses to environmental stimuli, such as exercise. Importantly, myomirs are also involved in the development of muscle atrophy arising from aging, immobility, prolonged exposure to microgravity, or muscular and neuromuscular disorders. Additionally, muscle atrophy is both induced by and exacerbates many important chronic and infectious diseases. As global yet specific muscle regulators, myomirs are also good candidates for therapeutic use. Understanding the dynamics of myomirs expression and their role in the development of disease is necessary to determine their potential for muscle atrophy prevention. WIREs RNA 2014, 5:509–525. doi: 10.1002/wrna.1227 This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development

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Myomirs involved in myogenesis.
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Myomir and protein involvement in atrophy and regeneration.
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Myomirs involved in healthy muscle homeostasis and fiber shift.
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RNA in Disease and Development > RNA in Development
RNA in Disease and Development > RNA in Disease
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs

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