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microRNAs: role in leukemia and their computational perspective

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Abstract MicroRNAs (miRNAs) belong to the family of noncoding RNAs (ncRNAs) and had gained importance due to its role in complex biochemical pathways. Changes in the expression of protein coding genes are the major cause of leukemia. Role of miRNAs as tumor suppressors has provided a new insight in the field of leukemia research. Particularly, the miRNAs mediated gene regulation involves the modulation of multiple mRNAs and cooperative action of different miRNAs to regulate a particular gene expression. This highly complex array of regulatory pathway network indicates the great possibility in analyzing and identifying novel findings. Owing to the conventional, slow experimental identification process of miRNAs and their targets, the last decade has witnessed the development of a large amount of computational approaches to deal with the complex interrelations present within biological systems. This article describes the various roles played by miRNAs in regulating leukemia and the role of computational approaches in exploring new possibilities. WIREs RNA 2015, 6:65–78. doi: 10.1002/wrna.1256 This article is categorized under: RNA in Disease and Development > RNA in Disease
An overview of miRNA biogenesis and its role in suppression of leukemia.
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Gene network constructed with the help of GENEMANIA tool, the upper figure, (a) shows black circles and gray circles which represent queried genes and the genes related to the queried genes respectively. The details of (b) and (c) are provided in the text.
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Association network between AML and CLL miRNAs. miR‐181a and miR‐228 shows the association between both CML and AML.
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The shared role of miRNAs in regulating various pathways provides basis for the construction of miRNA:target; miRNA:miRNA network.
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