This Title All WIREs
How to cite this WIREs title:
Impact Factor: 9.957

Noncoding RNA control of cellular senescence

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Senescent cells accumulate in normal tissues with advancing age and arise by long‐term culture of primary cells. Senescence develops following exposure to a range of stress‐causing agents and broadly influences the physiology and pathology of tissues, organs, and systems in the body. While many proteins are known to control senescence, numerous noncoding (nc)RNAs are also found to promote or repress the senescent phenotype. Here, we review the regulatory ncRNAs (primarily microRNAs and lncRNAs) identified to‐date as key modulators of senescence. We highlight the major senescent pathways (p53/p21 and pRB/p16), as well as the senescence‐associated secretory phenotype (SASP) and other senescence‐associated events governed by ncRNAs, and discuss the importance of understanding comprehensively the ncRNAs implicated in cell senescence. WIREs RNA 2015, 6:615–629. doi: 10.1002/wrna.1297 This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Development
ncRNAs promoting and inhibiting senescence. Schematic representation of the main microRNAs and lncRNAs that promote (black) or inhibit (white) senescence phenotypes driven by p53/p21 (top left) pRB/p16 (top right), SASP and other mediators (bottom). Center, senescent fibroblasts displaying blue color indicative of SA‐β‐galactosidase (SA‐β‐gal) activity.
[ Normal View | Magnified View ]

Browse by Topic

Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs
RNA in Disease and Development > RNA in Development
RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes
RNA in Disease and Development

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts