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Ancient and modern: hints of a core post‐transcriptional network driving chemotherapy resistance in ovarian cancer

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RNA‐binding proteins (RBPs) and noncoding (nc)RNAs (such as microRNAs, long ncRNAs, and others) cooperate within a post‐transcriptional network to regulate the expression of genes required for many aspects of cancer behavior including its sensitivity to chemotherapy. Here, using an RBP‐centric approach, we explore the current knowledge surrounding contributers to post‐transcriptional gene regulation (PTGR) in ovarian cancer and identify commonalities that hint at the existence of an evolutionarily conserved core PTGR network. This network regulates survival and chemotherapy resistance in the contemporary context of the cancer cell. There is emerging evidence that cancers become dependent on PTGR factors for their survival. Further understanding of this network may identify innovative therapeutic targets as well as yield crucial insights into the hard‐wiring of many malignancies, including ovarian cancer. WIREs RNA 2018, 9:e1432. doi: 10.1002/wrna.1432 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications Translation > Translation Mechanisms RNA in Disease and Development > RNA in Disease
(a)–(c) RNA‐binding proteins influence epithelial ovarian cancer (EOC) progression through complex networks with mRNAs, noncoding RNAs, and other proteins. (a) RNA‐binding motif protein 3 (RBM3) regulates platinum sensitivity and patient survival through regulation of mRNAs involved in apoptosis and the stress response. (b) HuR exerts an oncogenic effect through stabilization and therefore increased translation of a range of mRNAs. (c) RNA‐binding proteins, such as YB1, LARP1, and IMP1 may converge on multiple subsets of mRNAs and signaling pathways as part of a network that drives progression of EOC and/or resistance to chemotherapy.
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RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Translation > Translation Mechanisms
RNA in Disease and Development > RNA in Disease

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