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Dynamic and reversible RNA N6‐methyladenosine methylation

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N6‐methyladenosine (m6A) is the most abundant internal chemical modification in eukaryotic messenger RNAs (mRNAs). The discovery in 2011 that m6A is reversed by the fat mass and obesity‐associated protein stimulated extensive worldwide research efforts on the regulatory biological functions of dynamic m6A and other RNA modifications. The epitranscriptomic mark m6A is written, read, and erased through the activities of a complicated network of enzymes and other proteins. m6A‐binding proteins read m6A marks and transduce their downstream regulatory effects by altering RNA metabolic processes. In this review, we summarize the current knowledge of m6A modifications, with particular focus on the functions of its writer, eraser, and reader proteins in posttranscriptional gene regulation and discuss the impact of m6A marks on human health. This article is categorized under: RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease
The reversible N6‐methyladenosine (m6A) modification in mRNA is written by a m6A writer complex and erased by m6A demethylases in the nucleus
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The regulatory roles of N6‐methyladenosine reader proteins in RNA metabolism
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RNA in Disease and Development > RNA in Disease
RNA Processing > RNA Editing and Modification

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