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mRNA methylation in cell senescence

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Abstract Cellular senescence, a developmental program central to normal aging and aging pathologies, is robustly regulated at the post‐transcriptional level. This regulation involves the interaction of RNA‐binding proteins and noncoding RNAs with senescence‐associated messenger RNAs (mRNAs). There is increasing evidence that these associations are modulated by chemical modifications of specific mRNA nucleotides which can enhance or reduce the binding of regulatory factors. Recent technological advances in mass spectrometry, next‐generation sequencing, and genome mapping have improved markedly the detection of mRNA modifications. Given the rising interest in the epitranscriptomic control of gene expression in aging, we discuss our incipient understanding of the chemical mRNA modifications, specifically m6A and m5C, that influence cellular senescence. This article is categorized under: RNA Export and Localization > RNA Localization RNA Processing > RNA Editing and Modification
Senescence‐associated changes in m6A and m5C modifications. The main modifications reported in mRNAs encoding senescence‐associated proteins, m6A and m5C, are indicated (gray rectangles). Each modification can promote (green) or repress (purple) protein expression from the respective mRNAs. *mRNA methylation at m6A and m5C decreases as cells progress towards senescence. mRNA, messenger RNA
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RNA Processing > RNA Editing and Modification
RNA Export and Localization > RNA Localization

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