Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs RNA
Impact Factor: 6.846

The role of posttranslational modifications in the assembly of stress granules

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Abstract Stress granules (SGs) are aggregates of translationally silenced messenger ribonucleoprotein (mRNP) complexes induced by oxidative, osmotic, hypoxic, thermal, viral, and genotoxic stresses. Over the past decade, extensive research has identified key components of SGs, their molecular interactions, and impact on stress‐induced reprogramming of protein expression and cell survival. However, studies defining the signaling pathways that modulate SG assembly have only been launched recently. These studies reveal that posttranslational modifications of selected SG proteins play important roles in the regulation of SG assembly and function. Here we provide an overview of the signaling pathways and posttranslational protein modifications that regulate the assembly and function of SGs. Copyright © 2010 John Wiley & Sons, Ltd. This article is categorized under: Translation > Translation Regulation RNA Export and Localization > RNA Localization RNA Turnover and Surveillance > Regulation of RNA Stability

Hypusination of eIF5A via the polyamine biosynthetic pathway. ODC, ornithine decarboxylase; DHS, deoxyhypusine synthase; DOHH, deoxyhypusine hydroxylase. N1‐Guanyl‐1,7‐diaminoheptane (GC7) is a competitive inhibitor of DHS.

[ Normal View | Magnified View ]

Depletion of eukaryotic translation elongation factor 2 (eEF2) inhibits SG assembly. RDG3 (GFP‐G3BP, SG marker; RFP‐Dcp1a, PB marker) double stable cells were transfected with control (siCONT) or eEF2‐specific (siEEF2) siRNAs, then SGs were induced by treating with sodium arsenite (0.5 mM) for 30 min.

[ Normal View | Magnified View ]

Related Articles

Protein microarrays for genome‐wide posttranslational modification analysis (WIREs WIREs Systems Biology and Medicine)

Browse by Topic

RNA Turnover and Surveillance > Regulation of RNA Stability
RNA Export and Localization > RNA Localization
Translation > Translation Regulation

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts