This Title All WIREs
How to cite this WIREs title:
WIREs Syst Biol Med
Impact Factor: 4.275

Linking genome to epigenome

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Abstract Recent epigenomic studies have identified significant differences between developmental stages and cell types. While the importance of epigenetic regulation has been increasingly recognized, it remains unclear how the global epigenetic patterns are established and maintained. Here I review a number of recent studies with the emphasis on the role of the genomic sequence in shaping the epigenetic landscape. These studies strongly suggest that the sequence information is important not just for controlling target specificity but for orchestrating the diversity of epigenetic patterns among different cell types. The epigenome is maintained by the complex network of a large number of interactions. Integrative approaches are needed to gain insights into these networks. WIREs Syst Biol Med 2012. doi: 10.1002/wsbm.1165 This article is categorized under: Analytical and Computational Methods > Computational Methods Laboratory Methods and Technologies > Genetic/Genomic Methods Biological Mechanisms > Regulatory Biology

This WIREs title offers downloadable PowerPoint presentations of figures for non-profit, educational use, provided the content is not modified and full credit is given to the author and publication.

Download a PowerPoint presentation of all images

A model for the role of the genomic sequence in guiding genome‐wide epigenetic patterns. (a) The intrinsic association between an epigenetic mark and a genome locus is sequence‐dependent and can be quantified by a propensity score. (b) An epigenetic mark (represented by the stars) is constitutively recruited to regions with high propensity scores, mediated by interaction with general factors (represented by the ovals) that target distinct sequence features. These features are usually degenerative and are the main determinants of the propensity scores. On the opposite end, this mark is excluded from regions with low propensity score. In the middle range, the epigenetic pattern is highly variable among different cell types. Occupancy can be enhanced or inhibited because of interactions with many cell type specific factors (represented by other shapes).

[ Normal View | Magnified View ]

Related Articles

Epigenetics: An Interdisciplinary View

Browse by Topic

Analytical and Computational Methods > Computational Methods
Biological Mechanisms > Regulatory Biology
Laboratory Methods and Technologies > Genetic/Genomic Methods

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts