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WIREs Syst Biol Med
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Author Spotlight

Merryn Tawhai
Current Affiliation: Auckland Bioengineering Institute, University of Auckland, New Zealand
Research Area: lung modeling

"I chose this career because of my enjoyment of biology and mathematics, and an interest in human health. What maintains my interest is collaborating with excellent people in a field where my research can span from basic to clinical science and commercial application.”

Dr. Tawhai is a consortium PI for an NIH-funded Bioengineering Research Partnership, lead by Prof EA Hoffman (University of Iowa), to develop a digital Human Lung Atlas for quantitative image and model-based analysis of the lung.  Through this multi-disciplinary collaboration, she has developed methods for rapid conversion of medical imaging into subject-specific computational models of the lung and its airways and blood vessels. This has allowed the simulation of tissue deformation, ventilation, perfusion, and gas exchange through the entire lung on a subject-by-subject basis. She is also a cluster PI for a separate NIH grant studying multi-scale phenomena in airway hyper-responsiveness, lead by Prof MJ Sanderson (University of Massachusetts). This group has developed an experimentally-founded multi-scale model to link calcium dynamics in the contracting airway smooth muscle cell to spatially-distributed airway constriction in the breathing lung. In more clinically focused work, she is PI for a grant funded by the Health Research Council of New Zealand to study the evolution of pulmonary hypertension in pulmonary embolism.


http://www.bioeng.auckland.ac.nz/projects/lungs/

Articles by Merryn Tawhai

Multiscale image‐based modeling and simulation of gas flow and particle transport in the human lungs
Focus Article
WIREs WIREs Systems Biology and Medicine
Published Online: Jul 10 2013
DOI: 10.1002/wsbm.1234
Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative approaches for modeling regulation and function of the respiratory system
Overview
WIREs WIREs Systems Biology and Medicine
Published Online: Sep 09 2013
DOI: 10.1002/wsbm.1244
Abstract Full article on Wiley Online Library:   HTML | PDF
The lung physiome: merging imaging‐based measures with predictive computational models
Advanced Review
WIREs WIREs Systems Biology and Medicine
Published Online: May 05 2009
DOI: 10.1002/wsbm.17
Abstract Full article on Wiley Online Library:   HTML | PDF

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