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Author Spotlight

Mehmet Koyutürk
Current Affiliation: Department of Electrical Engineering and Computer Science at Case Western Reserve University
Research Area: bioinformatics and computational biology

"The secret of being a successful scientist is something I will try to figure out forever, but it appears to me that you at least need to trust your mind and not accept an explanation that does not make sense to you, no matter where it is coming from or how established it is."

-Mehmet Koyutürk

Dr. Mehmet Koyutürk obtained his B.S. and M.S. degrees in Electrical and Electronics Engineering and Computer Engineering from Bilkent University in 1998 and 2000, respectively. He was awarded his Ph.D. in Computer Science from Purdue University in 2006, and joined the Department of Electrical Engineering and Computer Science at Case Western Reserve University in 2007 as T. & D Schroeder Assistant Professor of Computer Science and Engineering. He has a secondary appointment at Case Center for Proteomics and Bioinformatics at CWRU School of Medicine.

Dr. Koyutürk’s research focuses on bioinformatics and computational biology, with particular emphasis on network biology, functional genomics and proteomics of complex phenotypes, and genomic structural variation. During his graduate studies, Dr. Koyutürk contributed to systems biology by developing algorithms for comparative network analysis and identification of canonical network patterns. Recently, he developed several algorithms that integrate various ‘omic datasets to address problems in systems biology of complex phenotypes, including discovery of dysregulated sub-networks in complex phenotypes, network-based prioritization of candidate disease genes, and detection of structural variants in human genome. In particular, in the context of colorectal cancer, Dr. Koyutürk and his colleagues showed that sub-network markers identified by combinatorial search algorithms can reveal specific cellular states descriptive of tumor progression, which can be used to make systems-level predictions on the mechanisms of metastasis.  In recognition and support of his research in this field, he received a CAREER Award from National Science Foundation in 2010. Dr. Koyutürk is a member of Case Comprehensive Cancer Center, International Society for Computational Biology, and Association for Computing Machinery.

For more information on Dr. Koyutürk's research, please visit http://vorlon.case.edu/~mxk331/

Articles by Mehmet Koyutürk

Algorithmic and analytical methods in network biology
WIREs WIREs Systems Biology and Medicine
Published Online: Apr 09 2010
DOI: 10.1002/wsbm.61
Abstract Full article on Wiley Online Library:   HTML | PDF

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