Brian Ciruna, Maria Jussila
Published Online: Mar 17 2017
DOI: 10.1002/wdev.267
Application of powerful genetics, embryonic cell‐transplantation, and live‐imaging capabilities afforded by the zebrafish model system has transformed our understanding of planar cell polarity (PCP) into a fundamental cellular property that orchestrates a diverse suite of polarized cell behaviors required for vertebrate embryonic development and adult homeostasis. Figure illustrates mediolateral intercalation of differentially‐labeled axial mesoderm cells within the zebrafish notochord.
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Karla Terrazas, Jill Dixon, Paul A. Trainor, Michael J. Dixon
Published Online: Feb 10 2017
DOI: 10.1002/wdev.263
Craniofacial anomalies account for approximately one‐third of all congenital birth defects. Here, we discuss the pathogenesis of a specific array of craniofacial anomalies, termed facial dysostoses, which affect development of the maxilla, mandible, and zygomatic arch.
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