Gary C. Schoenwolf, Sho Ohta
Published Online: Oct 11 2017
DOI: 10.1002/wdev.302
Summary of the known otocyst transcription factors regulated by crosstalk among three families of secreted proteins during dorsoventral (DV) patterning. DV patterning of the otocyst is orchestrated by crosstalk among three families of secreted proteins that regulate the expression of transcription factors in a temporospatial manner. BMP signaling, which is required for the development of the dorsal (vestibular) component of the inner ear, upregulates the expression of two transcription factors, Dlx5 and Hmx3, both of which are essential for vestibular development. WNT and BMP signaling partner to induce Dlx5 expression in the dorsolateral wall of the otocyst, whereas WNT signaling acts alone in the dorsomedial wall to regulate the expression of Gbx2, which in turn seems to be required for Dlx5 expression. SHH signaling, which is required for the development of the ventral (cochlear) component of the inner ear, upregulates the expression of two transcription factors, Pax2 and Otx2, both of which are essential for cochlear development. The expression of transcription factors in the dorsal and ventral otocyst also is inhibited by secreted factors, with BMP signaling downregulating Otx2 expression and SHH signaling downregulating Hmx3 expression and arguably downregulating Dlx5 expression.
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Hugh J. Clarke
Published Online: Sep 11 2017
DOI: 10.1002/wdev.294
All stages of postnatal oocyte development depend on communication with the neighboring somatic granulosa cells of the ovarian follicle. Signals sent by the oocyte also regulate differentiation of the granulosa cells and ensure that they provide a healthy environment for the germ cell.
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