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WIREs Dev Biol
Impact Factor: 5.814
Wiley Interdisciplinary Reviews:
WIREs Developmental Biology
Volume 9 Issue 1 (January 2020)
Page 0 - 0


The benefits differential equations bring to limb development
Published Online: Oct 22 2019
DOI: 10.1002/wdev.364
Systems biology uses differential‐equation based models to improve limb development understanding. Nine features of these models offer a translation in practical terms of their trade‐offs, from tissue size to multiple‐gene models.
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Advanced Reviews

Recent advancements in understanding fin regeneration in zebrafish
Published Online: Nov 14 2019
DOI: 10.1002/wdev.367
Zebrafish fins provide an excellent model to study cellular and molecular mechanisms of regeneration.
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Cellular mechanisms of epithelial stem cell self‐renewal and differentiation during homeostasis and repair
Published Online: Aug 29 2019
DOI: 10.1002/wdev.361
This chalkboard sketch conveys the concept that stem cells in adult epithelial tissues follow different trajectories for self‐renewal and differentiation depending on the context of their environment. Under conditions of homeostatic maintenance, stem cells transit through intermediate states to give rise to committed progenitors and mature cell types. During injury‐induced regeneration, stem cells become activated and traverse transient states unique to regeneration, before making the choice to self‐renew or differentiate. Finally, cellular plasticity, in which mature cells dedifferentiate to a multipotent state, can also contribute to cell replacement after injury.
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Signatures of sex: Sex differences in gene expression in the vertebrate brain
Published Online: May 20 2019
DOI: 10.1002/wdev.348
Two scenarios by which persistent sex differences in gene expression can arise in the developing brain: long‐term changes in chromatin state lead to increased levels of transcription of a given gene, or developmental programming of cell types results in an increased number of cells expressing that gene. Without single‐cell resolution, these outcomes cannot be identified.
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Using brain organoids to study human neurodevelopment, evolution and disease
Published Online: May 09 2019
DOI: 10.1002/wdev.347
Brain organoids are 3D tissue cultures generated from human induced pluripotent stem cells and can recapitulate the basic steps of the developing human brain. They can be used as a human‐specific model for studying brain development, evolution and disease.
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Focus Article

The Notch pathway in CNS homeostasis and neurodegeneration
Published Online: Sep 10 2019
DOI: 10.1002/wdev.358
The pleiotropic Notch signaling pathway affects CNS homeostasis and is implicated in adult neurogenesis, synaptic plasticity, and memory formation. It is also associated with both acute neural injury events such as ischemic stroke (most notably, the hereditary disorder Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) and progressive neurodegenerative diseases (e.g., Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis). (Figure created with BioRender).
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