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WIREs Nanomed Nanobiotechnol
Impact Factor: 9.182

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Wiley Interdisciplinary Reviews:
WIREs Nanomedicine and Nanobiotechnology
Volume 13 Issue 5 (September 2021)
Page 0 - 0

Overview

Protein nanoparticles in molecular, cellular, and tissue imaging
Published Online: Apr 05 2021
DOI: 10.1002/wnan.1714
Use of protein nanoparticles (PNPs) for MR, NIRF, CT, SPECT, PET, and US imaging. PNPs have been used as multifunctional nanocarriers and can be employed for simultaneous bioimaging and drug delivery for a wide range of imaging modalities. Surface functionalization enables PNP usage for specific targeting. SELF indicates targeting of natural receptors (e.g., transferrin) using unmodified PNP (e.g., ferritin) surface.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Nanomedicines for combating multidrug resistance of cancer
Published Online: Apr 15 2021
DOI: 10.1002/wnan.1715
Nanomedicines combining different strategies with chemotherapy for combating MDR.
Abstract Full article on Wiley Online Library:   HTML | PDF
The synergistic strategies for the immuno‐oncotherapy with photothermal nanoagents
Published Online: Apr 06 2021
DOI: 10.1002/wnan.1717
The concise synergistic strategies for the immuno‐oncotherapy based on the multifunctional nanomaterials (mfNMs) that consist of photothermal nanoagents, immunoadjuvants, and ICP inhibitors.
Abstract Full article on Wiley Online Library:   HTML | PDF
Advances in single‐molecule fluorescent nanosensors
Published Online: Mar 28 2021
DOI: 10.1002/wnan.1716
Integration of single‐molecule detection with functional nanomaterials enables the construction of various single‐molecule fluorescent nanosensors.
Abstract Full article on Wiley Online Library:   HTML | PDF
The effects of gene × environment interactions on silver nanoparticle toxicity in the respiratory system: An adverse outcome pathway
Published Online: Mar 25 2021
DOI: 10.1002/wnan.1708
AEP‐AOP framework. The AEP framework outlines source to target site exposure (only target site exposure shown); the AEP and AOP frameworks interface at the target site, where a molecular initiating event (MIE) occurs and is followed by key events (KE) for adverse cellular and organ responses along a biological pathway and ends with the adverse organism response.
Abstract Full article on Wiley Online Library:   HTML | PDF
Nanomaterials for Agricultural and Ecological Defense Applications: Active Agents and Sensors
Published Online: Mar 21 2021
DOI: 10.1002/wnan.1713
Applications of nanomaterials.
Abstract Full article on Wiley Online Library:   HTML | PDF
Hot melt extrusion: An emerging manufacturing method for slow and sustained protein delivery
Published Online: Mar 10 2021
DOI: 10.1002/wnan.1712
Traditional melt‐based polymer processing offers distinct advantages for manufacturing slow‐release pharmaceutical products, yet has received relatively little attention when used for therapeutic proteins. This article discusses recent examples, critical challenges, and presents potential solutions to encourage therapeutic protein formulations made through hot melt extrusion.
Abstract Full article on Wiley Online Library:   HTML | PDF
Fluorescent nanotechnology for in vivo imaging
Published Online: Mar 08 2021
DOI: 10.1002/wnan.1705
Nanoparticles (NPs) for in vivo imaging. Fluorescent NPs including fluorescent proteins, quantum dots, carbon dots, aggregation‐induced emission NPs, and upconversion NPs are powerful platform materials for imaging and therapy.
Abstract Full article on Wiley Online Library:   HTML | PDF
Point‐of‐critical‐care diagnostics for sepsis enabled by multiplexed micro and nanosensing technologies
Published Online: Mar 01 2021
DOI: 10.1002/wnan.1701
To reduce mortality from common yet complicated septic infections, micro and nanotechnologies which target multiple sepsis biomarkers can provide faster, more accurate, and personalized diagnosis to support early treatment.
Abstract Full article on Wiley Online Library:   HTML | PDF
Novel nanomaterial–organism hybrids with biomedical potential
Published Online: Feb 28 2021
DOI: 10.1002/wnan.1706
Rapid development of chemistry and materials science successfully obtained the combinations of organisms with nanomaterials by biomimetic mineralization. This review summarizes recent advances in materials‐directed organism engineering and emphasizes their outstanding biomedical applications.
Abstract Full article on Wiley Online Library:   HTML | PDF
Silver nanoparticles as a potential treatment against SARS‐CoV‐2: A review
Published Online: Feb 27 2021
DOI: 10.1002/wnan.1707
Bats are natural carriers of the new SARS‐CoV‐2 coronavirus, which can be transmitted to humans through certain intermediate hosts. AgNPs allow the internalization of the virus in the cells to be avoided by inhibiting the interaction between the spike (S) glycoprotein and its specific receptor. This study summarizes in vitro and in vivo studies in which AgNPs were used to counteract different viruses that cause respiratory diseases. In addition, the possible routes of AgNPs exposure and dose extrapolation to humans as a possible treatment for SARS‐CoV‐2 are analyzed.
Abstract Full article on Wiley Online Library:   HTML | PDF
Combined cancer therapeutics—Tackling the complexity of the tumor microenvironment
Published Online: Feb 09 2021
DOI: 10.1002/wnan.1704
Combined therapies are based on the use of nanoparticles that have an enhanced cargo release after stimulation with characteristics found in the tumor microenvironment (e.g., hypoxia, acidity, or ROS) combined with external stimuli (e.g., light, ultrasounds, or magnetic field).
Abstract Full article on Wiley Online Library:   HTML | PDF
Cancer‐associated‐platelet‐inspired nanomedicines for cancer therapy
Published Online: Feb 03 2021
DOI: 10.1002/wnan.1702
Cancer‐associated‐platelet‐targeting nanomedicines and platelet membranecoating nanomedicines.
Abstract Full article on Wiley Online Library:   HTML | PDF
Biohybrid robotics: From the nanoscale to the macroscale
Published Online: Feb 02 2021
DOI: 10.1002/wnan.1703
Bio‐hybrid robotics can be studied in terms of the scale of integration of the biological and artificial components, ranging from biomolecules like enzymes to multiple cells in the form of tissues.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Nanoparticle‐based applications for cervical cancer treatment in drug delivery, gene editing, and therapeutic cancer vaccines
Published Online: May 04 2021
DOI: 10.1002/wnan.1718
Recent progresses in nanoparticle‐based delivery systems show potential foreground for enhancing clinical benefits while minimizing systemic toxicities in cervical cancer.
Abstract Full article on Wiley Online Library:   HTML | PDF

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