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WIREs Nanomed Nanobiotechnol
Impact Factor: 7.689
Wiley Interdisciplinary Reviews:
WIREs Nanomedicine and Nanobiotechnology
Volume 12 Issue 3 (May 2020)
Page 0 - 0

Advanced Reviews

Recent advances on small‐molecule nanomedicines for cancer treatment
Published Online: Dec 15 2019
DOI: 10.1002/wnan.1607
Small molecules nanomedicines (SMNs) minimize or abandon the excipients and are directly assembled from pharmaceutical ingredients, which can largely improve the drug delivery efficiency and bio safety while also relieving the financial burden of drug development. The SMNs showed myriad merits include 1) High DL%. The SMNs that directly assembled by drugs can reach a 100% drug loading; 2) Green. The SMNs that co‐assembled or self‐assembled by physically mixing of drugs involves no chemical synthetic steps; 3) Bioavailability. The SMNs can extensively increase water solubility of hydrophobic drugs, thus improve the bioavailability. 4) Controllability. By introducing some functional building blocks, such as peptides, the morphology, drug release and DL% of SMNs can be highly controllable; 5) Multifunctionality. Some building blocks, such as photosensitizers, peptides and dyes, offer the SMNs with multiple functionalities; 6) Synergy. The synergistic effect between different drugs give better efficacy on cancer treatments; 7) Diagnosis. Imaging agents, such as dye and contrast agents, render SMNs with excellent diagnostic capability.
Abstract Full article on Wiley Online Library:   HTML | PDF
Fluorescent hybrid silica nanoparticles and their biomedical applications
Published Online: Dec 13 2019
DOI: 10.1002/wnan.1603
Fluorescent hybrid silica nanoparticles and their biomedical applications in bioimaging, anti‐tumor treatment, and biosensing.
Abstract Full article on Wiley Online Library:   HTML | PDF
Enhancing cancer therapeutic efficacy through ultrasound‐mediated micro‐to‐nano conversion
Published Online: Dec 12 2019
DOI: 10.1002/wnan.1604
Improving cancer diagnosis and therapy through ultrasound mediated micro‐to‐nano conversion.
Abstract Full article on Wiley Online Library:   HTML | PDF
Recent developments in the use of organic–inorganic nanohybrids for drug delivery
Published Online: Dec 11 2019
DOI: 10.1002/wnan.1605
Organic nanomaterials such as dendrimers, micelles, polymers, CNTs, and liposomes hybridizing with inorganic nanomaterials such as mesoporous silica, layered double hydroxides, halloysites, iron oxide, and hydroxyapatite to produce organic–inorganic nanohybrids (OINHs) as versatile drug delivery agents with improved characteristics such as higher drug loading, magnetic or receptor targeted delivery, and controlled release of drugs.
Abstract Full article on Wiley Online Library:   HTML | PDF
Strategies for nonviral nanoparticle‐based delivery of CRISPR/Cas9 therapeutics
Published Online: Dec 02 2019
DOI: 10.1002/wnan.1609
The Cas9 plasmid DNA, RNA, or protein delivery via nanoparticles for precise genome editing.
Abstract Full article on Wiley Online Library:   HTML | PDF
Protein‐protected metal nanoclusters: An emerging ultra‐small nanozyme
Published Online: Nov 14 2019
DOI: 10.1002/wnan.1602
Protein‐protected metal nanoclusters, while traditionally used as fluorescent labels, have recently emerged as an ultra‐small nanozyme (nanomaterials with intrinsic enzyme‐like activity), extending the horizon of their properties as well as their application in various fields.
Abstract Full article on Wiley Online Library:   HTML | PDF
Nanocarriers in photodynamic therapy—in vitro and in vivo studies
Published Online: Nov 06 2019
DOI: 10.1002/wnan.1599
The limitations of classical photodynamic therapy include hampered administration and cellular uptake of photosensitizers, as well as their disadvantageous distribution in the organism. A promising approach to overcome these obstacles involves the use of nanocarrier systems modulating biodistribution and improving pharmacokinetic and pharmacodynamic properties of the drugs.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Insight into the siRNA transmembrane delivery—From cholesterol conjugating to tagging
Published Online: Dec 01 2019
DOI: 10.1002/wnan.1606
Noncovalent decoration of small interfering RNA (siRNA) by cholesterol tags enables transmembrane delivery of siRNA into cytosol by membrane fusion.
Abstract Full article on Wiley Online Library:   HTML | PDF
Biocorona‐induced modifications in engineered nanomaterial–cellular interactions impacting biomedical applications
Published Online: Dec 01 2019
DOI: 10.1002/wnan.1608
Nanoparticles (NPs) enter a physiological system and associate a variety of biomolecules, forming a biocorona (BC). Addition of the BC alters cellular interactions and responses, potentially impacting biomedical efficacy of NPs.
Abstract Full article on Wiley Online Library:   HTML | PDF
Multifluid electrospinning for the generation of complex nanostructures
Published Online: Nov 06 2019
DOI: 10.1002/wnan.1601
Multifluid electrospinning for the generation of complex nanostructures.
Abstract Full article on Wiley Online Library:   HTML | PDF

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