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WIREs Nanomed Nanobiotechnol
Impact Factor: 9.182
Wiley Interdisciplinary Reviews:
WIREs Nanomedicine and Nanobiotechnology
Volume 13 Issue 3 (May 2021)
Page 0 - 0

Overview

Nanotechnology‐based approaches for treating lysosomal storage disorders, a focus on Fabry disease
Published Online: Dec 13 2020
DOI: 10.1002/wnan.1684
Enzyme replacement therapy (ERT) relays on the intravenous administration of very labile lysosomal enzymes that require complex glycosylation patterns to internalize into cells. Nanotechnology‐based approaches allow improving ERT by stabilizing the enzyme, improving its biodistribution and delivering the therapeutic protein directly to the lysosomes of affected cells.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Engineered nanomedicines for tumor vasculature blockade therapy
Published Online: Jan 21 2021
DOI: 10.1002/wnan.1691
Engineered nanomedicines are designed to provide prolonged circulation time, targeted transportation, and controlled release of tumor vasculature blockade therapy agents for angiogenesis inhibition, vascular disruption, and vascular infarction as an emerging therapy for various solid tumors.
Abstract Full article on Wiley Online Library:   HTML | PDF
Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology
Published Online: Jan 14 2021
DOI: 10.1002/wnan.1693
Nanomaterial development fuels progress in bioelectronic medicine and has allowed new applications in biological actuation, electroceutics, and electroanalytics.
Abstract Full article on Wiley Online Library:   HTML | PDF
Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery
Published Online: Jan 05 2021
DOI: 10.1002/wnan.1690
Nanoparticles have been investigated as a potential approach enhancing the lymphatic uptake of drugs. Through combination with microneedle delivery systems, this approach could potentially be useful in the passive and active delivery of nanoparticles to the lymphatic system via dermal lymphatic capillaries.
Abstract Full article on Wiley Online Library:   HTML | PDF
Virus‐mimetic systems for cancer diagnosis and therapy
Published Online: Dec 22 2020
DOI: 10.1002/wnan.1692
Virus‐mimetic nanoparticles hold great potential to be efficient delivery systems for cancer diagnosis and therapy.
Abstract Full article on Wiley Online Library:   HTML | PDF
Imaging as a tool to accelerate the translation of extracellular vesicle‐based therapies for central nervous system diseases
Published Online: Dec 17 2020
DOI: 10.1002/wnan.1688
Labeling extracellular vesicles for in vivo tracking of their accumulation in the brain.
Abstract Full article on Wiley Online Library:   HTML | PDF
The evolution of polymer conjugation and drug targeting for the delivery of proteins and bioactive molecules
Published Online: Dec 14 2020
DOI: 10.1002/wnan.1689
Schematic representation of the journey and the barriers that a nanomedicine such as a polymer‐drug conjugate faces as it travels from the site of injection to the target (e.g., the cancer site). It must remain stable in blood, escape macrophage endocytosis, extravasate at the right site, diffuse into the tumor, be internalized by the cancer cells and, finally, promptly release the drug.
Abstract Full article on Wiley Online Library:   HTML | PDF
Engineering spatiotemporal organization and dynamics in synthetic cells
Published Online: Nov 21 2020
DOI: 10.1002/wnan.1685
Self‐organizing systems and dynamics in space and time in synthetic cells.
Abstract Full article on Wiley Online Library:   HTML | PDF
Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy
Published Online: Nov 12 2020
DOI: 10.1002/wnan.1682
Representative nanomedicine designs for photothermal‐chemodynamic bimodal therapy.
Abstract Full article on Wiley Online Library:   HTML | PDF
Advancements in protein nanoparticle vaccine platforms to combat infectious disease
Published Online: Nov 08 2020
DOI: 10.1002/wnan.1681
Various protein nanoparticles (NPs) have been utilized as scaffolds to display antigens for vaccination against infectious agents. NPs can stimulate humoral immune responses, cellular immune responses, or a combination of both.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Cell mimicry as a bottom‐up strategy for hierarchical engineering of nature‐inspired entities
Published Online: Nov 17 2020
DOI: 10.1002/wnan.1683
Artificial enzymes, artificial organelles, and artificial cells as the three core building blocks in cell mimicry.
Abstract Full article on Wiley Online Library:   HTML | PDF

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