Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs RNA
Impact Factor: 9.957

Current Issue

Wiley Interdisciplinary Reviews:
WIREs RNA
Volume 12 Issue 5 (September 2021)
Page 0 - 0

Cover Image

Cover Image, Volume 12, Issue 5
Published Online: Aug 12 2021
DOI: 10.1002/wrna.1687
The cover image is based on the Advanced Review On the function and relevance of alternative 3′‐UTRs in gene expression regulation by Isabel Pereira‐Castro and Alexandra Moreira https://doi.org/10.1002/wrna.1653
Abstract Full article on Wiley Online Library:   HTML | PDF

Opinion

The potential versatility of RNA catalysis
Published Online: May 05 2021
DOI: 10.1002/wrna.1651
The coenzyme SAM bound to the SAM‐I riboswitch. The methyl group (cyan) is clearly accessible from the exterior of the RNA, potentially able to be transferred to an acceptor.
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

Single‐cell RNA sequencing: A new opportunity for retinal research
Published Online: Mar 22 2021
DOI: 10.1002/wrna.1652
After single‐cell RNA sequencing of samples, different analysis schemes are adopted for different research directions. This article focuses on the development of the retina, the study of retinal subtypes, and the exploration of the mechanisms of retinal diseases.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Unannotated splicing regulatory elements in deep intron space
Published Online: Apr 22 2021
DOI: 10.1002/wrna.1656
Splicing regulatory elements are frequently found in deep introns, far from exons they regulate. Black boxes, annotated exons; gray boxes, alternative exons. Colored boxes in upper panel represent regulatory exons and pseudoexons not present in mature mRNA, and in the lower panel represent docking and selector elements. Colored ovals indicate regulatory proteins.
Abstract Full article on Wiley Online Library:   HTML | PDF
On the function and relevance of alternative 3′‐UTRs in gene expression regulation
Published Online: Apr 12 2021
DOI: 10.1002/wrna.1653
Alternative 3′‐UTRs have a central role in regulating gene expression, revealing cell‐type‐specific signatures in different biological conditions that may be used as new biomarkers and therapeutic targets.
Abstract Full article on Wiley Online Library:   HTML | PDF
Evolutionary conservation of RNA sequence and structure
Published Online: Mar 22 2021
DOI: 10.1002/wrna.1649
Covariation together with covariation power allow to distinguish between three different conservation patterns in RNA alignments. Structural RNAs with evolutionary signal for a conserved structure have covariation and power (green). Non structural RNAs have power but no covariation (red). RNAs that lack both covariation and power are too conserved in sequence to be able to decide whether they have a conserved structure or not (blue). We show the covariation versus power observed in structural RNAs from the database Rfam (black), and the covariation and power for the long non‐coding RNAs HOTAIR, RepA‐Xist, and ncSRA that do not support a conserved RNA structure (brown)
Abstract Full article on Wiley Online Library:   HTML | PDF
Chemical methods for measuring RNA expression with metabolic labeling
Published Online: Mar 18 2021
DOI: 10.1002/wrna.1650
Schematic of cell‐specific metabolic labeling of RNA. Cell 1 depicts a wild‐type cell exposed to an inert intermediate that will not produce labeled RNA. Cell 2 is exposed to an inert intermediate that is activated by an exogenously expressed enzyme for subsequent metabolic incorporation by RNA polymerase producing labeled RNA. The chemical handle functionalizes RNA for isolation and analysis.
Abstract Full article on Wiley Online Library:   HTML | PDF
Translational remodeling by RNA‐binding proteins and noncoding RNAs
Published Online: Mar 10 2021
DOI: 10.1002/wrna.1647
Adaptive protein synthesis via translation efficiency reprogramming is an emerging pillar of cellular adaptation. Ho et al. discuss how networks of RNA‐binding proteins and long noncoding RNAs drive this translatome remodeling.
Abstract Full article on Wiley Online Library:   HTML | PDF
Nanocarrier‐delivered small interfering RNA for chemoresistant ovarian cancer therapy
Published Online: Mar 07 2021
DOI: 10.1002/wrna.1648
Nanocarrier‐mediated siRNA delivery and its mechanism of action
Abstract Full article on Wiley Online Library:   HTML | PDF

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts