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WIREs RNA
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Wiley Interdisciplinary Reviews:
WIREs RNA
Volume 11 Issue 6 (November 2020)
Page 0 - 0

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Cover Image
Published Online: Oct 08 2020
DOI: 10.1002/wrna.1629
The cover image is based on the Advanced Review Phase‐separated bacterial ribonucleoprotein bodies organize mRNA decay by Nisansala S. Muthunayake et al., https://doi.org/10.1002/wrna.1599.
Abstract Full article on Wiley Online Library:   HTML | PDF
Cover Image
Published Online: Oct 08 2020
DOI: 10.1002/wrna.1630
The cover image is based on the Advanced Review Unboxing the T‐box riboswitches—A glimpse into multivalent and multimodal RNA–RNA interactions by Jinwei Zhang https://doi.org/10.1002/wrna.1600.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Unboxing the T‐box riboswitches—A glimpse into multivalent and multimodal RNA–RNA interactions
Published Online: Jul 06 2020
DOI: 10.1002/wrna.1600
Recent elucidation of the structures and mechanisms of bacterial T‐box riboswitches provides insights into how structured noncoding RNAs interact with each other and regulate gene expression through multivalent contacts that go much beyond base pairing.
Abstract Full article on Wiley Online Library:   HTML | PDF
Patterning the Drosophila embryo: A paradigm for RNA‐based developmental genetic regulation
Published Online: Jun 15 2020
DOI: 10.1002/wrna.1610
Where the fly embryo forms its head and its abdomen is determined by maternal RNAs that are transported to the anterior or posterior poles of the developing oocyte, where they are anchored and translationally activated through complex and fascinating mechanisms.
Abstract Full article on Wiley Online Library:   HTML | PDF
tRNA methylation: An unexpected link to bacterial resistance and persistence to antibiotics and beyond
Published Online: Jun 13 2020
DOI: 10.1002/wrna.1609
Gram‐negative bacteria such as Escherichia coli and Salmonella use the TrmD‐catalyzed m1G37 methylation of tRNA to translate genes for the cell envelope double‐membrane structure. Active cell envelope confers multidrug resistance and persistence to these bacteria, permitting regrowth upon removal of antibiotics, whereas defective cell envelope sensitizes them to antibiotic killing.
Abstract Full article on Wiley Online Library:   HTML | PDF
Classification and function of RNA–protein interactions
Published Online: Jun 02 2020
DOI: 10.1002/wrna.1601
Classification of RNA–protein interactions. RNA–protein interactions can be divided into four classes according to the characteristics of these relationships, which are (a) RNA motif‐dependent RNA–protein interactions; (b) RNA structure‐dependent RNA–protein interactions; (c) RNA modification‐dependent RNA–protein interactions; and (d) RNA guide‐based RNA–protein interactions.
Abstract Full article on Wiley Online Library:   HTML | PDF
Phase‐separated bacterial ribonucleoprotein bodies organize mRNA decay
Published Online: May 23 2020
DOI: 10.1002/wrna.1599
Bacterial RNA degradosomes and RNA have been found to phase‐separate into membraneless assemblies called bacterial‐ribonucleoprotein bodies (BR‐bodies). BR‐bodies have similar properties to eukaryotic processing bodies and stress granules to organize the mRNA decay/processing machinery. Since bacteria typically lack membrane bound organelles, BR‐bodies, and more generally biomolecular condensates, are likely to play a critical role in organizing their biochemical pathways.
Abstract Full article on Wiley Online Library:   HTML | PDF
Unraveling the structure and biological functions of RNA triple helices
Published Online: May 22 2020
DOI: 10.1002/wrna.1598
The three‐dimensional structures of naturally occurring RNA triple helices are displayed with the three strands denoted in blue, purple, and green. Collectively, these RNA triple helices play important biological roles in catalysis, binding to ligands (orange), and stabilizing RNA.
Abstract Full article on Wiley Online Library:   HTML | PDF
Translational gene regulation in plants: A green new deal
Published Online: May 04 2020
DOI: 10.1002/wrna.1597
Recent advances in our understanding of translational gene regulation in plants include genome‐wide control phenomena, mechanistic insights into the translation apparatus, and emerging signal transduction pathways.
Abstract Full article on Wiley Online Library:   HTML | PDF
Changing faces of stress: Impact of heat and arsenite treatment on the composition of stress granules
Published Online: May 03 2020
DOI: 10.1002/wrna.1596
The modes of action of arsenite‐ and heat stress‐induced SG formation differ. Heat stress‐induced SGs might represent an intermediate stage between dynamic, fully reversible arsenite stress‐induced SGs and static, irreversible, disease‐linked aberrant SGs. Stress treatment conditions substantially influence SG protein composition and can initiate the transition of SGs to aberrant SGs.
Abstract Full article on Wiley Online Library:   HTML | PDF

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