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WIREs RNA
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Wiley Interdisciplinary Reviews:
WIREs RNA
Volume 11 Issue 2 (March 2020)
Page 0 - 0

Overview

Nuclear sorting of RNA
Published Online: Nov 11 2019
DOI: 10.1002/wrna.1572
RNA Polymerase II produces a wide range of transcripts destined for multiple fates within the cell. Accurate processing and localization of RNAs are essential processes in maintaining a stable transcriptome. RNAs can be accurately processed and sorted in the nucleus through a number of pathways for either export to the cytoplasm, retention in subnuclear compartments or targeting to decay machineries.
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Advanced Reviews

Connections between 3′ end processing and DNA damage response: Ten years later
Published Online: Oct 28 2019
DOI: 10.1002/wrna.1571
Categories of events and pathways involved at the intersection of mRNA 3′ end processing and DNA damage response.
Abstract Full article on Wiley Online Library:   HTML | PDF
Current overview on viroid–host interactions
Published Online: Oct 22 2019
DOI: 10.1002/wrna.1570
Putative working model for the viroid derived small RNA induced production of secondary siRNA in viroid infected host plant.
Abstract Full article on Wiley Online Library:   HTML | PDF
Highlighting transcribed ultraconserved regions in human diseases
Published Online: Sep 05 2019
DOI: 10.1002/wrna.1567
Transcribed ultraconserved regions (T‐UCRs) may be transcriptional regulated by specific transcription factors (TF) and DNA methylation (M), further, post‐transcriptional regulated by microRNAs (miRNAs). These expression regulations may be affected, and deregulated T‐UCRs have been associated with multifactorial diseases.
Abstract Full article on Wiley Online Library:   HTML | PDF
Cluster miRNAs and cancer: Diagnostic, prognostic and therapeutic opportunities
Published Online: Aug 22 2019
DOI: 10.1002/wrna.1563
Strategies for miRNA based therapy.
Abstract Full article on Wiley Online Library:   HTML | PDF
RNA mimicry in post‐transcriptional regulation by aminoacyl tRNA synthetases
Published Online: Aug 15 2019
DOI: 10.1002/wrna.1564
Aminoacyl tRNA synthetases (aaRSs) have a well‐established role in charging tRNA. Yet, aaRSs from various species have additional, non‐canonical roles in cellular functions. In this review we describe functions that affect mRNA functions post‐transcriptionally (noted in the sector with green background) and some non‐RNA functions (pink background).
Abstract Full article on Wiley Online Library:   HTML | PDF
Protein kinase R and its cellular regulators in cancer: An active player or a surveillant?
Published Online: Jun 23 2019
DOI: 10.1002/wrna.1558
Apoptosis and inflammation: two opposite outcomes of PKR activation in cancer.
Abstract Full article on Wiley Online Library:   HTML | PDF

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