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WIREs RNA
Impact Factor: 6.846
Wiley Interdisciplinary Reviews:
WIREs RNA
Volume 12 Issue 2 (March 2021)
Page 0 - 0

Cover Image

Cover Image
Published Online: Feb 19 2021
DOI: 10.1002/wrna.1646
The cover image is based on the Advanced Review The multifaceted eukaryotic cap structure by Jerry Pelletier et al., https://doi.org/10.1002/wrna.1636.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

The multifaceted eukaryotic cap structure
Published Online: Dec 09 2020
DOI: 10.1002/wrna.1636
Cap interplay with gene regulatory mechanisms associated with RNA biology.
Abstract Full article on Wiley Online Library:   HTML | PDF
RNA localization in prokaryotes: Where, when, how, and why
Published Online: Aug 27 2020
DOI: 10.1002/wrna.1615
Different localization patterns of mRNAs in bacteria.
Abstract Full article on Wiley Online Library:   HTML | PDF
Molecular and biological functions of TRIM‐NHL RNA‐binding proteins
Published Online: Aug 01 2020
DOI: 10.1002/wrna.1620
TRIM‐NHL proteins were known to be involved in an array of biological processes in various contexts. This includes tuning signaling pathways and post‐transcriptional gene regulation. The molecular underpinning of these activities, however, remained unknown until recent discoveries provided an answer: these proteins control gene expression by directly regulating mRNA decay and translation.
Abstract Full article on Wiley Online Library:   HTML | PDF
Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferases
Published Online: Jul 22 2020
DOI: 10.1002/wrna.1622
Terminal nucleotidyltransferases are a diverse group of enzymes that regulate many processes in metazoan cells. Here, we comprehensively summarize recent work on the role of posttranscriptional 3′ end RNA extensions in metabolism, organism development, and disease progression.
Abstract Full article on Wiley Online Library:   HTML | PDF
The multifaceted role of PARP1 in RNA biogenesis
Published Online: Jul 12 2020
DOI: 10.1002/wrna.1617
PARP1 plays functional roles in the mRNA life cycle: from biogenesis (transcription, splicing, and polyadenylation) to modifications (m6A), stability, export, and ribosome assembly (translation). This regulation occurs either through its direct binding to its binding partners (DNA, RNA, protein) and/or through PARylation or PAR recognition by target molecules.
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Fatal attraction: The roles of ribosomal proteins in the viral life cycle
Published Online: Jul 12 2020
DOI: 10.1002/wrna.1613
All viruses require host cell ribosomes for expression of viral proteins, starting a battle between the host cell and the virus for ribosomes. Viruses usurp specific ribosomal proteins to facilitate viral protein biosynthesis. Viruses directly or indirectly induce posttranslational modifications, or utilize extra‐ribosomal functions in other steps of the virus life cycle. In contrast, cells try to control and limit viruses' ribosome access, either by altering posttranslational modifications of ribosomes, by blocking viral replication, or by blocking other steps of the virus life cycle where ribosomal proteins function outside of the ribosome.
Abstract Full article on Wiley Online Library:   HTML | PDF
Making ends meet: New functions of mRNA secondary structure
Published Online: Jun 29 2020
DOI: 10.1002/wrna.1611
The intrinsic proximity of mRNA ends might facilitate the formation of protein complexes that regulate translation initiation by bridging the two ends of mRNAs.
Abstract Full article on Wiley Online Library:   HTML | PDF
The roles of hnRNP A2/B1 in RNA biology and disease
Published Online: Jun 26 2020
DOI: 10.1002/wrna.1612
hnRNPA2/B1 recognizes and binds specific RNA substrates and is involved in the transcription, splicing, transport, stability, and translation of a variety of RNAs. Its expression changes and mutations are involved in various tumors and neurodegenerative and autoimmune diseases.
Abstract Full article on Wiley Online Library:   HTML | PDF

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