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WIREs RNA
Impact Factor: 9.957
Wiley Interdisciplinary Reviews:
WIREs RNA
Volume 12 Issue 4 (July 2021)
Page 0 - 0

Cover Image

Cover Image
Published Online: Jun 11 2021
DOI: 10.1002/wrna.1677
The cover image is based on the Focus Article Uncovering targets of the Leader protease: Linking RNA‐mediated pathways and antiviral defense by Margarita Saiz and Encarnacion Martinez‐Salas, https://doi.org/10.1002/wrna.1645.
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

Therapeutic promise of engineered nonsense suppressor tRNAs
Published Online: Feb 10 2021
DOI: 10.1002/wrna.1641
Nonsense suppressor tRNAs display promise as therapeutic agents for suppressing premature termination codons, and alleviating disease through seamless rescue of full‐length protein and stabilized mRNA.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Splicing alterations in healthy aging and disease
Published Online: Feb 09 2021
DOI: 10.1002/wrna.1643
Splicing alterations during healthy aging and in disease. Aging is associated with changes in splicing factor (SF) expression and in differentially spliced isoforms, including in genes associated with aging hallmarks.
Abstract Full article on Wiley Online Library:   HTML | PDF
Ribosome heterogeneity and specialization in development
Published Online: Feb 09 2021
DOI: 10.1002/wrna.1644
Ribosome heterogeneity is found across a variety of species and its potential importance to development is being assessed to determine if these ribosomes are specialized.
Abstract Full article on Wiley Online Library:   HTML | PDF
Germ cell ribonucleoprotein granules in different clades of life: From insects to mammals
Published Online: Feb 08 2021
DOI: 10.1002/wrna.1642
Heritable and non heritable RNP granules mediate spatio‐temporal regulation of gene expression.
Abstract Full article on Wiley Online Library:   HTML | PDF
Dynamic transcriptomic m5C and its regulatory role in RNA processing
Published Online: Jan 13 2021
DOI: 10.1002/wrna.1639
High‐throughput sequencing technologies reveal that RNA 5‐methylcytosine plays dynamic regulatory roles in the diverse cellular processes via its writer, eraser, and reader.
Abstract Full article on Wiley Online Library:   HTML | PDF
Artificial miRNAs as therapeutic tools: Challenges and opportunities
Published Online: Jan 01 2021
DOI: 10.1002/wrna.1640
Artificial miRNAs as therapeutic tools.
Abstract Full article on Wiley Online Library:   HTML | PDF
Translational control in aging and neurodegeneration
Published Online: Sep 20 2020
DOI: 10.1002/wrna.1628
Altered translational dynamics in brain aging.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Uncovering targets of the Leader protease: Linking RNA‐mediated pathways and antiviral defense
Published Online: Feb 18 2021
DOI: 10.1002/wrna.1645
Overview of RNA‐binding proteins modifications operating in cells during RNA viral infections.
Abstract Full article on Wiley Online Library:   HTML | PDF

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