Drawings (left) and simulations (right) of experimentally manipulated (ZPA graft; chicken) (top), and mutant (Shh‐/‐Gli3‐/‐; mouse) (bottom) embryonic limbs.

A better understanding of immune cell response in tumors requires multiscale modeling of intracellular signaling, multicellular interactions, and spatial and whole‐body dynamics.

A schematic of a cardiac electrophysiology model, highlighting the components described by equations that need to be calibrated using experimental data.

Increased glucose uptake via the glucose transporter 1 (GLUT1) is essential for immune cell activation and is upregulated in different autoimmune diseases, like rheumatoid arthritis. Interference with GLUT1 using either genetic deletion or small molecules seems promising in different autoimmune mouse models and highlights the therapeutic potential of immunometabolism.