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WIREs Syst Biol Med
Impact Factor: 4.192

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Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 13 Issue 1 (January 2021)
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Computational modeling of the interactions between the maternal and fetal circulations in human pregnancy
Published Online: Aug 03 2020
DOI: 10.1002/wsbm.1502
The placenta develops over pregnancy to provide oxygen to the fetus, with this oxygen provided by maternal blood via the blood vessels in the uterus. Computational models, with varying complexity, have been derived to understand how the uterus and placenta interact to ensure a healthy pregnancy, and here we review these computational approaches with a view to translating new physiological insights into the clinic.
Abstract Full article on Wiley Online Library:   HTML | PDF
Single‐cell proteomic analysis
Published Online: Aug 03 2020
DOI: 10.1002/wsbm.1503
The recently developed single‐cell proteomic technologies will bring new insights into signaling network regulation, cell heterogeneity, tissue architecture, disease diagnosis, and treatment monitoring.
Abstract Full article on Wiley Online Library:   HTML | PDF
Liver fibrosis: Pathophysiology and clinical implications
Published Online: Jul 26 2020
DOI: 10.1002/wsbm.1499
Chronic viral infections, a diet rich in fat and alcohol abuse are responsible of chronic liver disease which progresses from fibrosis, to cirrhosis and eventually may cause hepatocellular carcinoma. Understanding the mechanism of liver fibrosis and its clinical implications is vital to develop new antifibrotic therapies.
Abstract Full article on Wiley Online Library:   HTML | PDF
Lights up on organelles: Optogenetic tools to control subcellular structure and organization
Published Online: Jul 26 2020
DOI: 10.1002/wsbm.1500
Optogenetic tools provide scientists with versatile strategies with which to manipulate subcellular structure and organization. These strategies have been employed to answer fundamental biological questions and to improve the efficiency of bioengineered cell factories. Created with BioRender.
Abstract Full article on Wiley Online Library:   HTML | PDF
Our natural “makeup” reveals more than it hides: Modeling the skin and its microbiome
Published Online: Jun 15 2020
DOI: 10.1002/wsbm.1497
The skin microbiome is strongly coupled with the skin resident immune and neuroendocrine systems, which in turn are coupled with their systemic counterparts. These systems together modulate the skin physiology. Pointed arrows indicate activation, blunt‐end arrows indicate inhibition.
Abstract Full article on Wiley Online Library:   HTML | PDF

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